Prophylactic catheter ablation for induced monomorphic ventricular tachycardia in patients with implantable cardioverter defibrillators as primary prevention
Prophylactic catheter ablation (CA) has been established to reduce the incidence of appropriate implantable cardioverter-defibrillator (ICD) therapy (anti-tachycardia pacing or shock) in secondary prevention patients. The aim of this study was to determine whether prophylactic CA for induced ventric...
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| Veröffentlicht in: | Europace (London, England) England), 2013-10, Vol.15 (10), p.1507-1515 |
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| creator | Hayashi, Takekuni Fukamizu, Seiji Hojo, Rintaro Komiyama, Kota Tanabe, Yasuhiro Tejima, Tamotsu Soejima, Kyoko Nishizaki, Mitsuhiro Hiraoka, Masayasu Ako, Junya Momomura, Shin-Ichi Sakurada, Harumizu |
| description | Prophylactic catheter ablation (CA) has been established to reduce the incidence of appropriate implantable cardioverter-defibrillator (ICD) therapy (anti-tachycardia pacing or shock) in secondary prevention patients. The aim of this study was to determine whether prophylactic CA for induced ventricular tachycardia (VT) reduces the incidence of appropriate ICD therapy in primary prevention patients.
We retrospectively investigated 66 consecutive patients with structural heart disease who had undergone ICD implantation as primary prevention and electrophysiological study. Patients with hypertrophic cardiomyopathy or no inducible monomorphic VT had been excluded, and the remaining 38 patients were divided into two groups; those who had undergone prophylactic CA for induced monomorphic VT (the CA group, n = 18), and those who had not undergone CA (the non-CA group, n = 20). During a mean follow-up of 50 ± 38 months, 1 patient (5%) received appropriate ICD therapy in the CA group and 13 (65%) in the non-CA group. Kaplan-Meier survival analysis revealed a significantly higher event-free survival rates for appropriate ICD therapy in the CA group compared with the non-CA group (P = 0.003). Among the patients, one patient (5%) in the CA group and nine patients (45%) in the non-CA group suffered appropriate shock (P = 0.018).
Prophylactic CA for induced monomorphic VT reduces the incidence of appropriate ICD therapy including shock in primary prevention patients. These results indicate that prophylactic CA may be considered for structural heart disease patients who are candidates for ICD implantation as primary prevention. |
| doi_str_mv | 10.1093/europace/eut050 |
| format | Article |
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We retrospectively investigated 66 consecutive patients with structural heart disease who had undergone ICD implantation as primary prevention and electrophysiological study. Patients with hypertrophic cardiomyopathy or no inducible monomorphic VT had been excluded, and the remaining 38 patients were divided into two groups; those who had undergone prophylactic CA for induced monomorphic VT (the CA group, n = 18), and those who had not undergone CA (the non-CA group, n = 20). During a mean follow-up of 50 ± 38 months, 1 patient (5%) received appropriate ICD therapy in the CA group and 13 (65%) in the non-CA group. Kaplan-Meier survival analysis revealed a significantly higher event-free survival rates for appropriate ICD therapy in the CA group compared with the non-CA group (P = 0.003). Among the patients, one patient (5%) in the CA group and nine patients (45%) in the non-CA group suffered appropriate shock (P = 0.018).
Prophylactic CA for induced monomorphic VT reduces the incidence of appropriate ICD therapy including shock in primary prevention patients. These results indicate that prophylactic CA may be considered for structural heart disease patients who are candidates for ICD implantation as primary prevention.</description><identifier>ISSN: 1099-5129</identifier><identifier>EISSN: 1532-2092</identifier><identifier>DOI: 10.1093/europace/eut050</identifier><identifier>PMID: 23603305</identifier><language>eng</language><publisher>England</publisher><subject>Aged ; Cardiomyopathies - diagnosis ; Cardiomyopathies - mortality ; Cardiomyopathies - physiopathology ; Cardiomyopathies - therapy ; Catheter Ablation ; Chi-Square Distribution ; Defibrillators, Implantable ; Disease-Free Survival ; Electric Countershock - adverse effects ; Electric Countershock - instrumentation ; Electric Countershock - mortality ; Electrophysiologic Techniques, Cardiac ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Patient Selection ; Primary Prevention - instrumentation ; Primary Prevention - methods ; Retrospective Studies ; Stroke Volume ; Tachycardia, Ventricular - diagnosis ; Tachycardia, Ventricular - mortality ; Tachycardia, Ventricular - physiopathology ; Tachycardia, Ventricular - prevention & control ; Time Factors ; Treatment Outcome ; Ventricular Function, Left</subject><ispartof>Europace (London, England), 2013-10, Vol.15 (10), p.1507-1515</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-7f828d13fc30cba378e44dbc2d15d68f9071f2d0352fe847de2104be7b2c4f273</citedby><cites>FETCH-LOGICAL-c338t-7f828d13fc30cba378e44dbc2d15d68f9071f2d0352fe847de2104be7b2c4f273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23603305$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hayashi, Takekuni</creatorcontrib><creatorcontrib>Fukamizu, Seiji</creatorcontrib><creatorcontrib>Hojo, Rintaro</creatorcontrib><creatorcontrib>Komiyama, Kota</creatorcontrib><creatorcontrib>Tanabe, Yasuhiro</creatorcontrib><creatorcontrib>Tejima, Tamotsu</creatorcontrib><creatorcontrib>Soejima, Kyoko</creatorcontrib><creatorcontrib>Nishizaki, Mitsuhiro</creatorcontrib><creatorcontrib>Hiraoka, Masayasu</creatorcontrib><creatorcontrib>Ako, Junya</creatorcontrib><creatorcontrib>Momomura, Shin-Ichi</creatorcontrib><creatorcontrib>Sakurada, Harumizu</creatorcontrib><title>Prophylactic catheter ablation for induced monomorphic ventricular tachycardia in patients with implantable cardioverter defibrillators as primary prevention</title><title>Europace (London, England)</title><addtitle>Europace</addtitle><description>Prophylactic catheter ablation (CA) has been established to reduce the incidence of appropriate implantable cardioverter-defibrillator (ICD) therapy (anti-tachycardia pacing or shock) in secondary prevention patients. The aim of this study was to determine whether prophylactic CA for induced ventricular tachycardia (VT) reduces the incidence of appropriate ICD therapy in primary prevention patients.
We retrospectively investigated 66 consecutive patients with structural heart disease who had undergone ICD implantation as primary prevention and electrophysiological study. Patients with hypertrophic cardiomyopathy or no inducible monomorphic VT had been excluded, and the remaining 38 patients were divided into two groups; those who had undergone prophylactic CA for induced monomorphic VT (the CA group, n = 18), and those who had not undergone CA (the non-CA group, n = 20). During a mean follow-up of 50 ± 38 months, 1 patient (5%) received appropriate ICD therapy in the CA group and 13 (65%) in the non-CA group. Kaplan-Meier survival analysis revealed a significantly higher event-free survival rates for appropriate ICD therapy in the CA group compared with the non-CA group (P = 0.003). Among the patients, one patient (5%) in the CA group and nine patients (45%) in the non-CA group suffered appropriate shock (P = 0.018).
Prophylactic CA for induced monomorphic VT reduces the incidence of appropriate ICD therapy including shock in primary prevention patients. These results indicate that prophylactic CA may be considered for structural heart disease patients who are candidates for ICD implantation as primary prevention.</description><subject>Aged</subject><subject>Cardiomyopathies - diagnosis</subject><subject>Cardiomyopathies - mortality</subject><subject>Cardiomyopathies - physiopathology</subject><subject>Cardiomyopathies - therapy</subject><subject>Catheter Ablation</subject><subject>Chi-Square Distribution</subject><subject>Defibrillators, Implantable</subject><subject>Disease-Free Survival</subject><subject>Electric Countershock - adverse effects</subject><subject>Electric Countershock - instrumentation</subject><subject>Electric Countershock - mortality</subject><subject>Electrophysiologic Techniques, Cardiac</subject><subject>Female</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patient Selection</subject><subject>Primary Prevention - instrumentation</subject><subject>Primary Prevention - methods</subject><subject>Retrospective Studies</subject><subject>Stroke Volume</subject><subject>Tachycardia, Ventricular - diagnosis</subject><subject>Tachycardia, Ventricular - mortality</subject><subject>Tachycardia, Ventricular - physiopathology</subject><subject>Tachycardia, Ventricular - prevention & control</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Ventricular Function, Left</subject><issn>1099-5129</issn><issn>1532-2092</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUFP3DAQhS1ExQLtmRvykUtgbCfr5IgQ0EpIcKDnyLHHilESB9sB7Y_pf62X3eU0I8037z3pEXLB4JpBI25wCX5WGvOSoIIjcsoqwQsODT_OOzRNUTHerMhZjG8AIHlTnZAVF2sQAqpT8u8lC_SbQenkNNUq9ZgwUNUNKjk_UesDdZNZNBo6-smPPsx9Jj9wSsHpZVCBJqX7jVbBOJVZOufPfI3006WeunEe1JSyINIvxn9g2FoYtK4LbshGPkSqIp2DG1XY5Ilb-Wz_k_ywaoj4az_Pyd-H-9e738XT8-Ofu9unQgtRp0LamteGCasF6E4JWWNZmk5zwyqzrm0DklluQFTcYl1Kg5xB2aHsuC4tl-KcXO105-DfF4ypHV3UmLNN6JfYslLIStY1rDN6s0N18DEGtO0-dsug3XbSHjppd53kj8u9-NKNaL75QwniP2zdkPA</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Hayashi, Takekuni</creator><creator>Fukamizu, Seiji</creator><creator>Hojo, Rintaro</creator><creator>Komiyama, Kota</creator><creator>Tanabe, Yasuhiro</creator><creator>Tejima, Tamotsu</creator><creator>Soejima, Kyoko</creator><creator>Nishizaki, Mitsuhiro</creator><creator>Hiraoka, Masayasu</creator><creator>Ako, Junya</creator><creator>Momomura, Shin-Ichi</creator><creator>Sakurada, Harumizu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201310</creationdate><title>Prophylactic catheter ablation for induced monomorphic ventricular tachycardia in patients with implantable cardioverter defibrillators as primary prevention</title><author>Hayashi, Takekuni ; Fukamizu, Seiji ; Hojo, Rintaro ; Komiyama, Kota ; Tanabe, Yasuhiro ; Tejima, Tamotsu ; Soejima, Kyoko ; Nishizaki, Mitsuhiro ; Hiraoka, Masayasu ; Ako, Junya ; Momomura, Shin-Ichi ; Sakurada, Harumizu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-7f828d13fc30cba378e44dbc2d15d68f9071f2d0352fe847de2104be7b2c4f273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Cardiomyopathies - diagnosis</topic><topic>Cardiomyopathies - mortality</topic><topic>Cardiomyopathies - physiopathology</topic><topic>Cardiomyopathies - therapy</topic><topic>Catheter Ablation</topic><topic>Chi-Square Distribution</topic><topic>Defibrillators, Implantable</topic><topic>Disease-Free Survival</topic><topic>Electric Countershock - adverse effects</topic><topic>Electric Countershock - instrumentation</topic><topic>Electric Countershock - mortality</topic><topic>Electrophysiologic Techniques, Cardiac</topic><topic>Female</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patient Selection</topic><topic>Primary Prevention - instrumentation</topic><topic>Primary Prevention - methods</topic><topic>Retrospective Studies</topic><topic>Stroke Volume</topic><topic>Tachycardia, Ventricular - diagnosis</topic><topic>Tachycardia, Ventricular - mortality</topic><topic>Tachycardia, Ventricular - physiopathology</topic><topic>Tachycardia, Ventricular - prevention & control</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hayashi, Takekuni</creatorcontrib><creatorcontrib>Fukamizu, Seiji</creatorcontrib><creatorcontrib>Hojo, Rintaro</creatorcontrib><creatorcontrib>Komiyama, Kota</creatorcontrib><creatorcontrib>Tanabe, Yasuhiro</creatorcontrib><creatorcontrib>Tejima, Tamotsu</creatorcontrib><creatorcontrib>Soejima, Kyoko</creatorcontrib><creatorcontrib>Nishizaki, Mitsuhiro</creatorcontrib><creatorcontrib>Hiraoka, Masayasu</creatorcontrib><creatorcontrib>Ako, Junya</creatorcontrib><creatorcontrib>Momomura, Shin-Ichi</creatorcontrib><creatorcontrib>Sakurada, Harumizu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Europace (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hayashi, Takekuni</au><au>Fukamizu, Seiji</au><au>Hojo, Rintaro</au><au>Komiyama, Kota</au><au>Tanabe, Yasuhiro</au><au>Tejima, Tamotsu</au><au>Soejima, Kyoko</au><au>Nishizaki, Mitsuhiro</au><au>Hiraoka, Masayasu</au><au>Ako, Junya</au><au>Momomura, Shin-Ichi</au><au>Sakurada, Harumizu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prophylactic catheter ablation for induced monomorphic ventricular tachycardia in patients with implantable cardioverter defibrillators as primary prevention</atitle><jtitle>Europace (London, England)</jtitle><addtitle>Europace</addtitle><date>2013-10</date><risdate>2013</risdate><volume>15</volume><issue>10</issue><spage>1507</spage><epage>1515</epage><pages>1507-1515</pages><issn>1099-5129</issn><eissn>1532-2092</eissn><abstract>Prophylactic catheter ablation (CA) has been established to reduce the incidence of appropriate implantable cardioverter-defibrillator (ICD) therapy (anti-tachycardia pacing or shock) in secondary prevention patients. The aim of this study was to determine whether prophylactic CA for induced ventricular tachycardia (VT) reduces the incidence of appropriate ICD therapy in primary prevention patients.
We retrospectively investigated 66 consecutive patients with structural heart disease who had undergone ICD implantation as primary prevention and electrophysiological study. Patients with hypertrophic cardiomyopathy or no inducible monomorphic VT had been excluded, and the remaining 38 patients were divided into two groups; those who had undergone prophylactic CA for induced monomorphic VT (the CA group, n = 18), and those who had not undergone CA (the non-CA group, n = 20). During a mean follow-up of 50 ± 38 months, 1 patient (5%) received appropriate ICD therapy in the CA group and 13 (65%) in the non-CA group. Kaplan-Meier survival analysis revealed a significantly higher event-free survival rates for appropriate ICD therapy in the CA group compared with the non-CA group (P = 0.003). Among the patients, one patient (5%) in the CA group and nine patients (45%) in the non-CA group suffered appropriate shock (P = 0.018).
Prophylactic CA for induced monomorphic VT reduces the incidence of appropriate ICD therapy including shock in primary prevention patients. These results indicate that prophylactic CA may be considered for structural heart disease patients who are candidates for ICD implantation as primary prevention.</abstract><cop>England</cop><pmid>23603305</pmid><doi>10.1093/europace/eut050</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford Journals Open Access Collection; PubMed Central; Alma/SFX Local Collection |
| subjects | Aged Cardiomyopathies - diagnosis Cardiomyopathies - mortality Cardiomyopathies - physiopathology Cardiomyopathies - therapy Catheter Ablation Chi-Square Distribution Defibrillators, Implantable Disease-Free Survival Electric Countershock - adverse effects Electric Countershock - instrumentation Electric Countershock - mortality Electrophysiologic Techniques, Cardiac Female Humans Kaplan-Meier Estimate Male Middle Aged Patient Selection Primary Prevention - instrumentation Primary Prevention - methods Retrospective Studies Stroke Volume Tachycardia, Ventricular - diagnosis Tachycardia, Ventricular - mortality Tachycardia, Ventricular - physiopathology Tachycardia, Ventricular - prevention & control Time Factors Treatment Outcome Ventricular Function, Left |
| title | Prophylactic catheter ablation for induced monomorphic ventricular tachycardia in patients with implantable cardioverter defibrillators as primary prevention |
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