Lycopene from Tomatoes: Vesicular Nanocarrier Formulations for Dermal Delivery
This experimental work aimed to develop a simple, fast, economic, and environmentally friendly process for the extraction of lycopene from tomato and incorporate this lycopene-rich extract into ultradeformable vesicular nanocarriers suitable for topical application. Lycopene extraction was conducted...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2013-07, Vol.61 (30), p.7284-7293 |
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| container_title | Journal of agricultural and food chemistry |
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| creator | Ascenso, Andreia Pinho, Sónia Eleutério, Carla Praça, Fabíola Garcia Bentley, Maria Vitória Lopes Badra Oliveira, Helena Santos, Conceição Silva, Olga Simões, Sandra |
| description | This experimental work aimed to develop a simple, fast, economic, and environmentally friendly process for the extraction of lycopene from tomato and incorporate this lycopene-rich extract into ultradeformable vesicular nanocarriers suitable for topical application. Lycopene extraction was conducted without a cosolvent for 30 min. The extracts were analyzed and incorporated in transfersomes and ethosomes. These formulations were characterized, and the cellular uptake was observed by confocal microscopy. Dermal delivery of lycopene formulations was tested under in vitro and in vivo conditions. Lycopene extraction proved to be quite safe and selective. The vesicular formulation was taken up by the cells, being more concentrated around the nucleus. Epicutaneous application of lycopene formulations decreased the level of anthralin-induced ear swelling by 97 and 87%, in a manner nonstatistically different from the positive control. These results support the idea that the lycopene-rich extract may be a good alternative to the expensive commercial lycopene for incorporation into advanced topical delivery systems. |
| doi_str_mv | 10.1021/jf401368w |
| format | Article |
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Lycopene extraction was conducted without a cosolvent for 30 min. The extracts were analyzed and incorporated in transfersomes and ethosomes. These formulations were characterized, and the cellular uptake was observed by confocal microscopy. Dermal delivery of lycopene formulations was tested under in vitro and in vivo conditions. Lycopene extraction proved to be quite safe and selective. The vesicular formulation was taken up by the cells, being more concentrated around the nucleus. Epicutaneous application of lycopene formulations decreased the level of anthralin-induced ear swelling by 97 and 87%, in a manner nonstatistically different from the positive control. These results support the idea that the lycopene-rich extract may be a good alternative to the expensive commercial lycopene for incorporation into advanced topical delivery systems.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf401368w</identifier><identifier>PMID: 23826819</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject><![CDATA[Administration, Cutaneous ; Animals ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - metabolism ; Antioxidants - administration & dosage ; Antioxidants - chemistry ; Antioxidants - isolation & purification ; Antioxidants - metabolism ; Biological and medical sciences ; Carotenoids - administration & dosage ; Carotenoids - chemistry ; Carotenoids - isolation & purification ; Carotenoids - metabolism ; Cell Line, Tumor ; Chemistry, Pharmaceutical - methods ; Drug Carriers - chemistry ; Drug Carriers - metabolism ; Drug Delivery Systems ; ears ; Female ; Food engineering ; Food industries ; Fruit and vegetable industries ; Fundamental and applied biological sciences. Psychology ; General aspects ; Humans ; Inflammation - drug therapy ; Keratinocytes - drug effects ; Keratinocytes - immunology ; Keratinocytes - metabolism ; lycopene ; Lycopersicon esculentum - chemistry ; Mice ; microscopy ; Plant Extracts - administration & dosage ; Plant Extracts - chemistry ; Plant Extracts - isolation & purification ; Plant Extracts - metabolism ; tomatoes ; topical application]]></subject><ispartof>Journal of agricultural and food chemistry, 2013-07, Vol.61 (30), p.7284-7293</ispartof><rights>Copyright © 2013 American Chemical Society</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a435t-adc8d054c4de0e7b712708b566e0562349fcbfb873ba52ad47a969bdbe80a5e23</citedby><cites>FETCH-LOGICAL-a435t-adc8d054c4de0e7b712708b566e0562349fcbfb873ba52ad47a969bdbe80a5e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf401368w$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf401368w$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27623765$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23826819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ascenso, Andreia</creatorcontrib><creatorcontrib>Pinho, Sónia</creatorcontrib><creatorcontrib>Eleutério, Carla</creatorcontrib><creatorcontrib>Praça, Fabíola Garcia</creatorcontrib><creatorcontrib>Bentley, Maria Vitória Lopes Badra</creatorcontrib><creatorcontrib>Oliveira, Helena</creatorcontrib><creatorcontrib>Santos, Conceição</creatorcontrib><creatorcontrib>Silva, Olga</creatorcontrib><creatorcontrib>Simões, Sandra</creatorcontrib><title>Lycopene from Tomatoes: Vesicular Nanocarrier Formulations for Dermal Delivery</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>This experimental work aimed to develop a simple, fast, economic, and environmentally friendly process for the extraction of lycopene from tomato and incorporate this lycopene-rich extract into ultradeformable vesicular nanocarriers suitable for topical application. Lycopene extraction was conducted without a cosolvent for 30 min. The extracts were analyzed and incorporated in transfersomes and ethosomes. These formulations were characterized, and the cellular uptake was observed by confocal microscopy. Dermal delivery of lycopene formulations was tested under in vitro and in vivo conditions. Lycopene extraction proved to be quite safe and selective. The vesicular formulation was taken up by the cells, being more concentrated around the nucleus. Epicutaneous application of lycopene formulations decreased the level of anthralin-induced ear swelling by 97 and 87%, in a manner nonstatistically different from the positive control. These results support the idea that the lycopene-rich extract may be a good alternative to the expensive commercial lycopene for incorporation into advanced topical delivery systems.</description><subject>Administration, Cutaneous</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Anti-Inflammatory Agents - isolation & purification</subject><subject>Anti-Inflammatory Agents - metabolism</subject><subject>Antioxidants - administration & dosage</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - metabolism</subject><subject>Biological and medical sciences</subject><subject>Carotenoids - administration & dosage</subject><subject>Carotenoids - chemistry</subject><subject>Carotenoids - isolation & purification</subject><subject>Carotenoids - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Carriers - metabolism</subject><subject>Drug Delivery Systems</subject><subject>ears</subject><subject>Female</subject><subject>Food engineering</subject><subject>Food industries</subject><subject>Fruit and vegetable industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Humans</subject><subject>Inflammation - drug therapy</subject><subject>Keratinocytes - drug effects</subject><subject>Keratinocytes - immunology</subject><subject>Keratinocytes - metabolism</subject><subject>lycopene</subject><subject>Lycopersicon esculentum - chemistry</subject><subject>Mice</subject><subject>microscopy</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - metabolism</subject><subject>tomatoes</subject><subject>topical application</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0E1P3DAQBmCrApWF9tA_ALlUoofQsRPHXm4VLR_Sih74uEYTZ1xllcTLeEO1_x5Xu4ULp5HGj16PXiG-SDiToOT3pS9BFpX9-0HMpFaQayntnphBesytruSBOIxxCQBWG_goDlRhVWXlfCZuFxsXVjRS5jkM2X0YcB0onmePFDs39cjZLY7BIXNHnF0GHtJy3YUxZj5w9pN4wD6Nvnsm3nwS-x77SJ9380g8XP66v7jOF7-vbi5-LHIsC73OsXW2BV26siUg0xipDNhGVxWBrlRRzr1rfGNN0aBW2JYG59W8aRuygJpUcSROt7krDk8TxXU9dNFR3-NIYYq1LAujjTXGJPptSx2HGJl8veJuQN7UEup_9dWv9SV7vIudmoHaV_m_rwS-7gBGh71nHF0X35xJx5tKJ3eydR5DjX84mYc7BbKE9JO0yrwloYv1Mkw8pr7eOekFLVuM5A</recordid><startdate>20130731</startdate><enddate>20130731</enddate><creator>Ascenso, Andreia</creator><creator>Pinho, Sónia</creator><creator>Eleutério, Carla</creator><creator>Praça, Fabíola Garcia</creator><creator>Bentley, Maria Vitória Lopes Badra</creator><creator>Oliveira, Helena</creator><creator>Santos, Conceição</creator><creator>Silva, Olga</creator><creator>Simões, Sandra</creator><general>American Chemical Society</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130731</creationdate><title>Lycopene from Tomatoes: Vesicular Nanocarrier Formulations for Dermal Delivery</title><author>Ascenso, Andreia ; Pinho, Sónia ; Eleutério, Carla ; Praça, Fabíola Garcia ; Bentley, Maria Vitória Lopes Badra ; Oliveira, Helena ; Santos, Conceição ; Silva, Olga ; Simões, Sandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a435t-adc8d054c4de0e7b712708b566e0562349fcbfb873ba52ad47a969bdbe80a5e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Administration, Cutaneous</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Anti-Inflammatory Agents - chemistry</topic><topic>Anti-Inflammatory Agents - isolation & purification</topic><topic>Anti-Inflammatory Agents - metabolism</topic><topic>Antioxidants - administration & dosage</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - metabolism</topic><topic>Biological and medical sciences</topic><topic>Carotenoids - administration & dosage</topic><topic>Carotenoids - chemistry</topic><topic>Carotenoids - isolation & purification</topic><topic>Carotenoids - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Carriers - metabolism</topic><topic>Drug Delivery Systems</topic><topic>ears</topic><topic>Female</topic><topic>Food engineering</topic><topic>Food industries</topic><topic>Fruit and vegetable industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Humans</topic><topic>Inflammation - drug therapy</topic><topic>Keratinocytes - drug effects</topic><topic>Keratinocytes - immunology</topic><topic>Keratinocytes - metabolism</topic><topic>lycopene</topic><topic>Lycopersicon esculentum - chemistry</topic><topic>Mice</topic><topic>microscopy</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - metabolism</topic><topic>tomatoes</topic><topic>topical application</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ascenso, Andreia</creatorcontrib><creatorcontrib>Pinho, Sónia</creatorcontrib><creatorcontrib>Eleutério, Carla</creatorcontrib><creatorcontrib>Praça, Fabíola Garcia</creatorcontrib><creatorcontrib>Bentley, Maria Vitória Lopes Badra</creatorcontrib><creatorcontrib>Oliveira, Helena</creatorcontrib><creatorcontrib>Santos, Conceição</creatorcontrib><creatorcontrib>Silva, Olga</creatorcontrib><creatorcontrib>Simões, Sandra</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ascenso, Andreia</au><au>Pinho, Sónia</au><au>Eleutério, Carla</au><au>Praça, Fabíola Garcia</au><au>Bentley, Maria Vitória Lopes Badra</au><au>Oliveira, Helena</au><au>Santos, Conceição</au><au>Silva, Olga</au><au>Simões, Sandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lycopene from Tomatoes: Vesicular Nanocarrier Formulations for Dermal Delivery</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2013-07-31</date><risdate>2013</risdate><volume>61</volume><issue>30</issue><spage>7284</spage><epage>7293</epage><pages>7284-7293</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>This experimental work aimed to develop a simple, fast, economic, and environmentally friendly process for the extraction of lycopene from tomato and incorporate this lycopene-rich extract into ultradeformable vesicular nanocarriers suitable for topical application. Lycopene extraction was conducted without a cosolvent for 30 min. The extracts were analyzed and incorporated in transfersomes and ethosomes. These formulations were characterized, and the cellular uptake was observed by confocal microscopy. Dermal delivery of lycopene formulations was tested under in vitro and in vivo conditions. Lycopene extraction proved to be quite safe and selective. The vesicular formulation was taken up by the cells, being more concentrated around the nucleus. Epicutaneous application of lycopene formulations decreased the level of anthralin-induced ear swelling by 97 and 87%, in a manner nonstatistically different from the positive control. These results support the idea that the lycopene-rich extract may be a good alternative to the expensive commercial lycopene for incorporation into advanced topical delivery systems.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>23826819</pmid><doi>10.1021/jf401368w</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Cutaneous Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - metabolism Antioxidants - administration & dosage Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - metabolism Biological and medical sciences Carotenoids - administration & dosage Carotenoids - chemistry Carotenoids - isolation & purification Carotenoids - metabolism Cell Line, Tumor Chemistry, Pharmaceutical - methods Drug Carriers - chemistry Drug Carriers - metabolism Drug Delivery Systems ears Female Food engineering Food industries Fruit and vegetable industries Fundamental and applied biological sciences. Psychology General aspects Humans Inflammation - drug therapy Keratinocytes - drug effects Keratinocytes - immunology Keratinocytes - metabolism lycopene Lycopersicon esculentum - chemistry Mice microscopy Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - metabolism tomatoes topical application |
| title | Lycopene from Tomatoes: Vesicular Nanocarrier Formulations for Dermal Delivery |
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