Low Salt Intake and Changes in Serum Sodium Levels in the Combination Therapy of Low-Dose Hydrochlorothiazide and Angiotensin II Receptor Blocker
Background: The present study was conducted to examine the association of dietary salt intake with changes in serum sodium (srNa) levels when angiotensin II receptor blocker (ARB) treatment is changed to the combination of ARB plus low-dose diuretic (hydrochlorothiazide [HCTZ]). Methods and Results:...
Gespeichert in:
| Veröffentlicht in: | Circulation Journal 2013, Vol.77(10), pp.2567-2572 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2572 |
|---|---|
| container_issue | 10 |
| container_start_page | 2567 |
| container_title | Circulation Journal |
| container_volume | 77 |
| creator | Nakayama, Masafumi Tomiyama, Hirofumi Kuwajima, Iwao Saito, Tetsushi Hokama, Yohei Fujii, Yuji Shimizu, Tadanori Nakayama, Tohru Yamashina, Akira Aizawa, Yoshifusa |
| description | Background: The present study was conducted to examine the association of dietary salt intake with changes in serum sodium (srNa) levels when angiotensin II receptor blocker (ARB) treatment is changed to the combination of ARB plus low-dose diuretic (hydrochlorothiazide [HCTZ]). Methods and Results: In 88 patients (age 70±12 years), ARB treatment was switched to the combination therapy (same dosage ARB+12.5mg/day HCTZ). The srNa level was measured before and 6 months after administration of the combination. The daily salt intake was estimated by the Kawasaki formula using second morning urine sample. The study subjects were divided into quintile ranges according to daily salt intake. The reduction in srNa levels by switching to the combination treatment was significant in subjects in the lowest quintile Q5 (≤8.9g/day salt intake), but not in those in Q1–4 (28.1–9.3g/day salt intake). Increases in serum creatinine and uric acid levels were significantly larger in the former group than in the latter group. Conclusions: In elderly Japanese subjects with low salt intake ( |
| doi_str_mv | 10.1253/circj.CJ-13-0287 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1437577581</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1437577581</sourcerecordid><originalsourceid>FETCH-LOGICAL-c596t-f09dca3fd5f322794d760aac2471ef475ba0d52664689231ff01e8cb471accff3</originalsourceid><addsrcrecordid>eNpFkU1v1DAQhi0EoqVw54R85JLijzhOjiWFdquVkNhytrzOeONtYi-2F7T9F_3HZD9oLx7L88xjaV6EPlJySZngX4yLZn3Z3hWUF4TV8hU6p7yURVkz8vpwr4qmLvkZepfSmhDWENG8RWeM15wJys7R0zz8xQs9ZDzzWT8A1r7Dba_9ChJ2Hi8gbke8CJ2byhz-wHB4zj3gNoxL53V2weP7HqLe7HCweBIW1yEBvt11MZh-CDHk3ulH1x3tV37lQgafJs9shn-CgU0OEX8dgnmA-B69sXpI8OFUL9Cv79_u29ti_uNm1l7NCyOaKheWNJ3R3HbCcsZkU3ayIlobVkoKtpRiqUknWFWVVd0wTq0lFGqznNraGGv5Bfp89G5i-L2FlNXokoFh0B7CNilacimkFDWdUHJETQwpRbBqE92o405RovZBqEMQqr1TlKt9ENPIp5N9uxyhex74v_kJuDkC65T1Cp4BHbMzA5yMUu6_mM4X9QvR66jA83-JCqBR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1437577581</pqid></control><display><type>article</type><title>Low Salt Intake and Changes in Serum Sodium Levels in the Combination Therapy of Low-Dose Hydrochlorothiazide and Angiotensin II Receptor Blocker</title><source>J-STAGE Free</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Nakayama, Masafumi ; Tomiyama, Hirofumi ; Kuwajima, Iwao ; Saito, Tetsushi ; Hokama, Yohei ; Fujii, Yuji ; Shimizu, Tadanori ; Nakayama, Tohru ; Yamashina, Akira ; Aizawa, Yoshifusa</creator><creatorcontrib>Nakayama, Masafumi ; Tomiyama, Hirofumi ; Kuwajima, Iwao ; Saito, Tetsushi ; Hokama, Yohei ; Fujii, Yuji ; Shimizu, Tadanori ; Nakayama, Tohru ; Yamashina, Akira ; Aizawa, Yoshifusa</creatorcontrib><description>Background: The present study was conducted to examine the association of dietary salt intake with changes in serum sodium (srNa) levels when angiotensin II receptor blocker (ARB) treatment is changed to the combination of ARB plus low-dose diuretic (hydrochlorothiazide [HCTZ]). Methods and Results: In 88 patients (age 70±12 years), ARB treatment was switched to the combination therapy (same dosage ARB+12.5mg/day HCTZ). The srNa level was measured before and 6 months after administration of the combination. The daily salt intake was estimated by the Kawasaki formula using second morning urine sample. The study subjects were divided into quintile ranges according to daily salt intake. The reduction in srNa levels by switching to the combination treatment was significant in subjects in the lowest quintile Q5 (≤8.9g/day salt intake), but not in those in Q1–4 (28.1–9.3g/day salt intake). Increases in serum creatinine and uric acid levels were significantly larger in the former group than in the latter group. Conclusions: In elderly Japanese subjects with low salt intake (<8.9g/day), the addition of a low-dose diuretic (12.5mg HCTZ) to ARB treatment causes significant reduction in srNa levels, which might affect blood osmolarity. (Circ J 2013; 77: 2567–2572)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-13-0287</identifier><identifier>PMID: 23832512</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Aged ; Aged, 80 and over ; Angiotensin II receptor blocker ; Angiotensin Receptor Antagonists - administration & dosage ; Diuretics ; Diuretics - administration & dosage ; Female ; Humans ; Hydrochlorothiazide - administration & dosage ; Hyponatremia ; Male ; Middle Aged ; Salt intake ; Sodium - blood ; Sodium - urine ; Sodium Chloride, Dietary - administration & dosage ; Sodium Chloride, Dietary - urine</subject><ispartof>Circulation Journal, 2013, Vol.77(10), pp.2567-2572</ispartof><rights>2013 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c596t-f09dca3fd5f322794d760aac2471ef475ba0d52664689231ff01e8cb471accff3</citedby><cites>FETCH-LOGICAL-c596t-f09dca3fd5f322794d760aac2471ef475ba0d52664689231ff01e8cb471accff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23832512$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakayama, Masafumi</creatorcontrib><creatorcontrib>Tomiyama, Hirofumi</creatorcontrib><creatorcontrib>Kuwajima, Iwao</creatorcontrib><creatorcontrib>Saito, Tetsushi</creatorcontrib><creatorcontrib>Hokama, Yohei</creatorcontrib><creatorcontrib>Fujii, Yuji</creatorcontrib><creatorcontrib>Shimizu, Tadanori</creatorcontrib><creatorcontrib>Nakayama, Tohru</creatorcontrib><creatorcontrib>Yamashina, Akira</creatorcontrib><creatorcontrib>Aizawa, Yoshifusa</creatorcontrib><title>Low Salt Intake and Changes in Serum Sodium Levels in the Combination Therapy of Low-Dose Hydrochlorothiazide and Angiotensin II Receptor Blocker</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background: The present study was conducted to examine the association of dietary salt intake with changes in serum sodium (srNa) levels when angiotensin II receptor blocker (ARB) treatment is changed to the combination of ARB plus low-dose diuretic (hydrochlorothiazide [HCTZ]). Methods and Results: In 88 patients (age 70±12 years), ARB treatment was switched to the combination therapy (same dosage ARB+12.5mg/day HCTZ). The srNa level was measured before and 6 months after administration of the combination. The daily salt intake was estimated by the Kawasaki formula using second morning urine sample. The study subjects were divided into quintile ranges according to daily salt intake. The reduction in srNa levels by switching to the combination treatment was significant in subjects in the lowest quintile Q5 (≤8.9g/day salt intake), but not in those in Q1–4 (28.1–9.3g/day salt intake). Increases in serum creatinine and uric acid levels were significantly larger in the former group than in the latter group. Conclusions: In elderly Japanese subjects with low salt intake (<8.9g/day), the addition of a low-dose diuretic (12.5mg HCTZ) to ARB treatment causes significant reduction in srNa levels, which might affect blood osmolarity. (Circ J 2013; 77: 2567–2572)</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angiotensin II receptor blocker</subject><subject>Angiotensin Receptor Antagonists - administration & dosage</subject><subject>Diuretics</subject><subject>Diuretics - administration & dosage</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrochlorothiazide - administration & dosage</subject><subject>Hyponatremia</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Salt intake</subject><subject>Sodium - blood</subject><subject>Sodium - urine</subject><subject>Sodium Chloride, Dietary - administration & dosage</subject><subject>Sodium Chloride, Dietary - urine</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1v1DAQhi0EoqVw54R85JLijzhOjiWFdquVkNhytrzOeONtYi-2F7T9F_3HZD9oLx7L88xjaV6EPlJySZngX4yLZn3Z3hWUF4TV8hU6p7yURVkz8vpwr4qmLvkZepfSmhDWENG8RWeM15wJys7R0zz8xQs9ZDzzWT8A1r7Dba_9ChJ2Hi8gbke8CJ2byhz-wHB4zj3gNoxL53V2weP7HqLe7HCweBIW1yEBvt11MZh-CDHk3ulH1x3tV37lQgafJs9shn-CgU0OEX8dgnmA-B69sXpI8OFUL9Cv79_u29ti_uNm1l7NCyOaKheWNJ3R3HbCcsZkU3ayIlobVkoKtpRiqUknWFWVVd0wTq0lFGqznNraGGv5Bfp89G5i-L2FlNXokoFh0B7CNilacimkFDWdUHJETQwpRbBqE92o405RovZBqEMQqr1TlKt9ENPIp5N9uxyhex74v_kJuDkC65T1Cp4BHbMzA5yMUu6_mM4X9QvR66jA83-JCqBR</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Nakayama, Masafumi</creator><creator>Tomiyama, Hirofumi</creator><creator>Kuwajima, Iwao</creator><creator>Saito, Tetsushi</creator><creator>Hokama, Yohei</creator><creator>Fujii, Yuji</creator><creator>Shimizu, Tadanori</creator><creator>Nakayama, Tohru</creator><creator>Yamashina, Akira</creator><creator>Aizawa, Yoshifusa</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2013</creationdate><title>Low Salt Intake and Changes in Serum Sodium Levels in the Combination Therapy of Low-Dose Hydrochlorothiazide and Angiotensin II Receptor Blocker</title><author>Nakayama, Masafumi ; Tomiyama, Hirofumi ; Kuwajima, Iwao ; Saito, Tetsushi ; Hokama, Yohei ; Fujii, Yuji ; Shimizu, Tadanori ; Nakayama, Tohru ; Yamashina, Akira ; Aizawa, Yoshifusa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c596t-f09dca3fd5f322794d760aac2471ef475ba0d52664689231ff01e8cb471accff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angiotensin II receptor blocker</topic><topic>Angiotensin Receptor Antagonists - administration & dosage</topic><topic>Diuretics</topic><topic>Diuretics - administration & dosage</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrochlorothiazide - administration & dosage</topic><topic>Hyponatremia</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Salt intake</topic><topic>Sodium - blood</topic><topic>Sodium - urine</topic><topic>Sodium Chloride, Dietary - administration & dosage</topic><topic>Sodium Chloride, Dietary - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakayama, Masafumi</creatorcontrib><creatorcontrib>Tomiyama, Hirofumi</creatorcontrib><creatorcontrib>Kuwajima, Iwao</creatorcontrib><creatorcontrib>Saito, Tetsushi</creatorcontrib><creatorcontrib>Hokama, Yohei</creatorcontrib><creatorcontrib>Fujii, Yuji</creatorcontrib><creatorcontrib>Shimizu, Tadanori</creatorcontrib><creatorcontrib>Nakayama, Tohru</creatorcontrib><creatorcontrib>Yamashina, Akira</creatorcontrib><creatorcontrib>Aizawa, Yoshifusa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakayama, Masafumi</au><au>Tomiyama, Hirofumi</au><au>Kuwajima, Iwao</au><au>Saito, Tetsushi</au><au>Hokama, Yohei</au><au>Fujii, Yuji</au><au>Shimizu, Tadanori</au><au>Nakayama, Tohru</au><au>Yamashina, Akira</au><au>Aizawa, Yoshifusa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low Salt Intake and Changes in Serum Sodium Levels in the Combination Therapy of Low-Dose Hydrochlorothiazide and Angiotensin II Receptor Blocker</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2013</date><risdate>2013</risdate><volume>77</volume><issue>10</issue><spage>2567</spage><epage>2572</epage><pages>2567-2572</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background: The present study was conducted to examine the association of dietary salt intake with changes in serum sodium (srNa) levels when angiotensin II receptor blocker (ARB) treatment is changed to the combination of ARB plus low-dose diuretic (hydrochlorothiazide [HCTZ]). Methods and Results: In 88 patients (age 70±12 years), ARB treatment was switched to the combination therapy (same dosage ARB+12.5mg/day HCTZ). The srNa level was measured before and 6 months after administration of the combination. The daily salt intake was estimated by the Kawasaki formula using second morning urine sample. The study subjects were divided into quintile ranges according to daily salt intake. The reduction in srNa levels by switching to the combination treatment was significant in subjects in the lowest quintile Q5 (≤8.9g/day salt intake), but not in those in Q1–4 (28.1–9.3g/day salt intake). Increases in serum creatinine and uric acid levels were significantly larger in the former group than in the latter group. Conclusions: In elderly Japanese subjects with low salt intake (<8.9g/day), the addition of a low-dose diuretic (12.5mg HCTZ) to ARB treatment causes significant reduction in srNa levels, which might affect blood osmolarity. (Circ J 2013; 77: 2567–2572)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>23832512</pmid><doi>10.1253/circj.CJ-13-0287</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1346-9843 |
| ispartof | Circulation Journal, 2013, Vol.77(10), pp.2567-2572 |
| issn | 1346-9843 1347-4820 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1437577581 |
| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Aged, 80 and over Angiotensin II receptor blocker Angiotensin Receptor Antagonists - administration & dosage Diuretics Diuretics - administration & dosage Female Humans Hydrochlorothiazide - administration & dosage Hyponatremia Male Middle Aged Salt intake Sodium - blood Sodium - urine Sodium Chloride, Dietary - administration & dosage Sodium Chloride, Dietary - urine |
| title | Low Salt Intake and Changes in Serum Sodium Levels in the Combination Therapy of Low-Dose Hydrochlorothiazide and Angiotensin II Receptor Blocker |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T18%3A25%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%20Salt%20Intake%20and%20Changes%20in%20Serum%20Sodium%20Levels%20in%20the%20Combination%20Therapy%20of%20Low-Dose%20Hydrochlorothiazide%20and%20Angiotensin%20II%20Receptor%20Blocker&rft.jtitle=Circulation%20Journal&rft.au=Nakayama,%20Masafumi&rft.date=2013&rft.volume=77&rft.issue=10&rft.spage=2567&rft.epage=2572&rft.pages=2567-2572&rft.issn=1346-9843&rft.eissn=1347-4820&rft_id=info:doi/10.1253/circj.CJ-13-0287&rft_dat=%3Cproquest_cross%3E1437577581%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1437577581&rft_id=info:pmid/23832512&rfr_iscdi=true |