Predictive value of elevated D-dimer in patients undergoing primary angioplasty for ST elevation myocardial infarction
The aim of this study was to evaluate the prognostic value of D-dimer in patients with STEMI undergoing primary percutaneous coronary intervention (PCI). The prognostic value of D-dimer has been documented in patients with acute coronary syndrome without ST-segment elevation. However, its value in a...
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| Veröffentlicht in: | Blood coagulation & fibrinolysis 2013-10, Vol.24 (7), p.704-710 |
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| creator | Akgul, Ozgur Uyarel, Huseyin Pusuroglu, Hamdi Gul, Mehmet Isiksacan, Nilgun Turen, Selahattin Erturk, Mehmet Surgit, Ozgur Cetin, Mustafa Bulut, Umit Baycan, Omer F. Uslu, Nevzat |
| description | The aim of this study was to evaluate the prognostic value of D-dimer in patients with STEMI undergoing primary percutaneous coronary intervention (PCI). The prognostic value of D-dimer has been documented in patients with acute coronary syndrome without ST-segment elevation. However, its value in acute ST-segment elevation myocardial infarction (STEMI) remains unclear. We prospectively enrolled 453 consecutive STEMI patients (mean age 55.6 ± 12.4 years, 364 male, 89 female) undergoing primary PCI. The study population was divided into tertiles based on admission D-dimer values. The high D-dimer group (n = 151) was defined as a value in the third tertile [>0.72 ug/ml fibrinogen equivalent units (FEU)], and the low D-dimer group (n = 302) included those patients with a value in the lower two tertiles (≤0.72 ug/ml FEU). Clinical characteristics, in-hospital and 6-month outcomes of primary PCI were analyzed. The patients of the high D-dimer group were older (mean age 60.1 ± 13.5 versus 52.4 ± 10.6, P |
| doi_str_mv | 10.1097/MBC.0b013e3283610396 |
| format | Article |
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The prognostic value of D-dimer has been documented in patients with acute coronary syndrome without ST-segment elevation. However, its value in acute ST-segment elevation myocardial infarction (STEMI) remains unclear. We prospectively enrolled 453 consecutive STEMI patients (mean age 55.6 ± 12.4 years, 364 male, 89 female) undergoing primary PCI. The study population was divided into tertiles based on admission D-dimer values. The high D-dimer group (n = 151) was defined as a value in the third tertile [>0.72 ug/ml fibrinogen equivalent units (FEU)], and the low D-dimer group (n = 302) included those patients with a value in the lower two tertiles (≤0.72 ug/ml FEU). Clinical characteristics, in-hospital and 6-month outcomes of primary PCI were analyzed. The patients of the high D-dimer group were older (mean age 60.1 ± 13.5 versus 52.4 ± 10.6, P < 0.001). Higher in-hospital cardiovascular mortality and 6-month all-cause mortality rates were observed in the high D-dimer group (7.2 versus 0.6%, P < 0.001 and 13.9 versus 2%, P < 0.001, respectively). In Cox multivariate analysis; a high admission D-dimer value (>0.72 ug/ml FEU) was found to be a powerful independent predictor of 6-month all-cause mortality (odds ratio10.1, 95% confidence interval1.24–42.73, P = 0.03). These results suggest that a high admission D-dimer, level was associated with increased in-hospital cardiovascular mortality and 6-month all-cause mortality in patients with STEMI undergoing primary PCI.</description><identifier>ISSN: 0957-5235</identifier><identifier>EISSN: 1473-5733</identifier><identifier>DOI: 10.1097/MBC.0b013e3283610396</identifier><identifier>PMID: 23571687</identifier><language>eng</language><publisher>England: Wolters Kluwer Health | Lippincott Williams & Wilkins</publisher><subject>Angioplasty, Balloon, Coronary - methods ; Female ; Fibrin Fibrinogen Degradation Products - metabolism ; Humans ; Male ; Middle Aged ; Myocardial Infarction - blood ; Myocardial Infarction - surgery ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Risk Factors ; Treatment Outcome</subject><ispartof>Blood coagulation & fibrinolysis, 2013-10, Vol.24 (7), p.704-710</ispartof><rights>2013 Wolters Kluwer Health | Lippincott Williams & Wilkins</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4226-8af741fbeb63dd262532b6899a9fb8210da11449775ef48f81df329024c7a0903</citedby><cites>FETCH-LOGICAL-c4226-8af741fbeb63dd262532b6899a9fb8210da11449775ef48f81df329024c7a0903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23571687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akgul, Ozgur</creatorcontrib><creatorcontrib>Uyarel, Huseyin</creatorcontrib><creatorcontrib>Pusuroglu, Hamdi</creatorcontrib><creatorcontrib>Gul, Mehmet</creatorcontrib><creatorcontrib>Isiksacan, Nilgun</creatorcontrib><creatorcontrib>Turen, Selahattin</creatorcontrib><creatorcontrib>Erturk, Mehmet</creatorcontrib><creatorcontrib>Surgit, Ozgur</creatorcontrib><creatorcontrib>Cetin, Mustafa</creatorcontrib><creatorcontrib>Bulut, Umit</creatorcontrib><creatorcontrib>Baycan, Omer F.</creatorcontrib><creatorcontrib>Uslu, Nevzat</creatorcontrib><title>Predictive value of elevated D-dimer in patients undergoing primary angioplasty for ST elevation myocardial infarction</title><title>Blood coagulation & fibrinolysis</title><addtitle>Blood Coagul Fibrinolysis</addtitle><description>The aim of this study was to evaluate the prognostic value of D-dimer in patients with STEMI undergoing primary percutaneous coronary intervention (PCI). The prognostic value of D-dimer has been documented in patients with acute coronary syndrome without ST-segment elevation. However, its value in acute ST-segment elevation myocardial infarction (STEMI) remains unclear. We prospectively enrolled 453 consecutive STEMI patients (mean age 55.6 ± 12.4 years, 364 male, 89 female) undergoing primary PCI. The study population was divided into tertiles based on admission D-dimer values. The high D-dimer group (n = 151) was defined as a value in the third tertile [>0.72 ug/ml fibrinogen equivalent units (FEU)], and the low D-dimer group (n = 302) included those patients with a value in the lower two tertiles (≤0.72 ug/ml FEU). Clinical characteristics, in-hospital and 6-month outcomes of primary PCI were analyzed. The patients of the high D-dimer group were older (mean age 60.1 ± 13.5 versus 52.4 ± 10.6, P < 0.001). Higher in-hospital cardiovascular mortality and 6-month all-cause mortality rates were observed in the high D-dimer group (7.2 versus 0.6%, P < 0.001 and 13.9 versus 2%, P < 0.001, respectively). In Cox multivariate analysis; a high admission D-dimer value (>0.72 ug/ml FEU) was found to be a powerful independent predictor of 6-month all-cause mortality (odds ratio10.1, 95% confidence interval1.24–42.73, P = 0.03). These results suggest that a high admission D-dimer, level was associated with increased in-hospital cardiovascular mortality and 6-month all-cause mortality in patients with STEMI undergoing primary PCI.</description><subject>Angioplasty, Balloon, Coronary - methods</subject><subject>Female</subject><subject>Fibrin Fibrinogen Degradation Products - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - surgery</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Treatment Outcome</subject><issn>0957-5235</issn><issn>1473-5733</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PGzEQhq2qiKQp_6BCPvay1F-7to-QlrZSKpCg55V3PQ4G7zrYu4ny71mUwKGHnkYaPe8zmhehL5RcUKLltz9XywvSEMqBM8UrSriuPqA5FZIXpeT8I5oTXcqiZLycoU85PxJCuFDyFM2mlaSVknO0vU1gfTv4LeCtCSPg6DAE2JoBLP5eWN9Bwr7HGzN46IeMx95CWkffr_Em-c6kPTb92sdNMHnYYxcTvrs_KnzscbePrUnWmzBpnEnt6_YzOnEmZDg7zgX6e_3jfvmrWN38_L28XBWtYKwqlHFSUNdAU3FrWcVKzppKaW20axSjxBpKhdBSluCEcopax5kmTLTSEE34An09eDcpPo-Qh7rzuYUQTA9xzDUVXFKqheATKg5om2LOCVx9fK-mpH5tvJ4ar_9tfIqdHy-MTQf2PfRW8QSoA7CLYYCUn8K4g1Q_gAnDw__dL130j6k</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Akgul, Ozgur</creator><creator>Uyarel, Huseyin</creator><creator>Pusuroglu, Hamdi</creator><creator>Gul, Mehmet</creator><creator>Isiksacan, Nilgun</creator><creator>Turen, Selahattin</creator><creator>Erturk, Mehmet</creator><creator>Surgit, Ozgur</creator><creator>Cetin, Mustafa</creator><creator>Bulut, Umit</creator><creator>Baycan, Omer F.</creator><creator>Uslu, Nevzat</creator><general>Wolters Kluwer Health | Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201310</creationdate><title>Predictive value of elevated D-dimer in patients undergoing primary angioplasty for ST elevation myocardial infarction</title><author>Akgul, Ozgur ; Uyarel, Huseyin ; Pusuroglu, Hamdi ; Gul, Mehmet ; Isiksacan, Nilgun ; Turen, Selahattin ; Erturk, Mehmet ; Surgit, Ozgur ; Cetin, Mustafa ; Bulut, Umit ; Baycan, Omer F. ; Uslu, Nevzat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4226-8af741fbeb63dd262532b6899a9fb8210da11449775ef48f81df329024c7a0903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Angioplasty, Balloon, Coronary - methods</topic><topic>Female</topic><topic>Fibrin Fibrinogen Degradation Products - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - surgery</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akgul, Ozgur</creatorcontrib><creatorcontrib>Uyarel, Huseyin</creatorcontrib><creatorcontrib>Pusuroglu, Hamdi</creatorcontrib><creatorcontrib>Gul, Mehmet</creatorcontrib><creatorcontrib>Isiksacan, Nilgun</creatorcontrib><creatorcontrib>Turen, Selahattin</creatorcontrib><creatorcontrib>Erturk, Mehmet</creatorcontrib><creatorcontrib>Surgit, Ozgur</creatorcontrib><creatorcontrib>Cetin, Mustafa</creatorcontrib><creatorcontrib>Bulut, Umit</creatorcontrib><creatorcontrib>Baycan, Omer F.</creatorcontrib><creatorcontrib>Uslu, Nevzat</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood coagulation & fibrinolysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akgul, Ozgur</au><au>Uyarel, Huseyin</au><au>Pusuroglu, Hamdi</au><au>Gul, Mehmet</au><au>Isiksacan, Nilgun</au><au>Turen, Selahattin</au><au>Erturk, Mehmet</au><au>Surgit, Ozgur</au><au>Cetin, Mustafa</au><au>Bulut, Umit</au><au>Baycan, Omer F.</au><au>Uslu, Nevzat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive value of elevated D-dimer in patients undergoing primary angioplasty for ST elevation myocardial infarction</atitle><jtitle>Blood coagulation & fibrinolysis</jtitle><addtitle>Blood Coagul Fibrinolysis</addtitle><date>2013-10</date><risdate>2013</risdate><volume>24</volume><issue>7</issue><spage>704</spage><epage>710</epage><pages>704-710</pages><issn>0957-5235</issn><eissn>1473-5733</eissn><abstract>The aim of this study was to evaluate the prognostic value of D-dimer in patients with STEMI undergoing primary percutaneous coronary intervention (PCI). The prognostic value of D-dimer has been documented in patients with acute coronary syndrome without ST-segment elevation. However, its value in acute ST-segment elevation myocardial infarction (STEMI) remains unclear. We prospectively enrolled 453 consecutive STEMI patients (mean age 55.6 ± 12.4 years, 364 male, 89 female) undergoing primary PCI. The study population was divided into tertiles based on admission D-dimer values. The high D-dimer group (n = 151) was defined as a value in the third tertile [>0.72 ug/ml fibrinogen equivalent units (FEU)], and the low D-dimer group (n = 302) included those patients with a value in the lower two tertiles (≤0.72 ug/ml FEU). Clinical characteristics, in-hospital and 6-month outcomes of primary PCI were analyzed. The patients of the high D-dimer group were older (mean age 60.1 ± 13.5 versus 52.4 ± 10.6, P < 0.001). Higher in-hospital cardiovascular mortality and 6-month all-cause mortality rates were observed in the high D-dimer group (7.2 versus 0.6%, P < 0.001 and 13.9 versus 2%, P < 0.001, respectively). In Cox multivariate analysis; a high admission D-dimer value (>0.72 ug/ml FEU) was found to be a powerful independent predictor of 6-month all-cause mortality (odds ratio10.1, 95% confidence interval1.24–42.73, P = 0.03). These results suggest that a high admission D-dimer, level was associated with increased in-hospital cardiovascular mortality and 6-month all-cause mortality in patients with STEMI undergoing primary PCI.</abstract><cop>England</cop><pub>Wolters Kluwer Health | Lippincott Williams & Wilkins</pub><pmid>23571687</pmid><doi>10.1097/MBC.0b013e3283610396</doi><tpages>7</tpages></addata></record> |
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| ispartof | Blood coagulation & fibrinolysis, 2013-10, Vol.24 (7), p.704-710 |
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| subjects | Angioplasty, Balloon, Coronary - methods Female Fibrin Fibrinogen Degradation Products - metabolism Humans Male Middle Aged Myocardial Infarction - blood Myocardial Infarction - surgery Predictive Value of Tests Prognosis Prospective Studies Risk Factors Treatment Outcome |
| title | Predictive value of elevated D-dimer in patients undergoing primary angioplasty for ST elevation myocardial infarction |
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