The Chemical Basis of Serine Palmitoyltransferase Inhibition by Myriocin

Sphingolipids (SLs) are essential components of cellular membranes formed from the condensation of l-serine and a long-chain acyl thioester. This first step is catalyzed by the pyridoxal-5′-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT) which is a promising therapeutic target. Th...

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Veröffentlicht in:	Journal of the American Chemical Society 2013-09, Vol.135 (38), p.14276-14285
Hauptverfasser:	Wadsworth, John M, Clarke, David J, McMahon, Stephen A, Lowther, Jonathan P, Beattie, Ashley E, Langridge-Smith, Pat R. R, Broughton, Howard B, Dunn, Teresa M, Naismith, James H, Campopiano, Dominic J
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallography, X-Ray Fatty Acids, Monounsaturated - chemistry Kinetics Mutation Recombinant Proteins - chemistry Serine C-Palmitoyltransferase - antagonists & inhibitors Serine C-Palmitoyltransferase - chemistry Serine C-Palmitoyltransferase - genetics Sphingomonas - enzymology Sphingomonas - genetics
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