Developmental transition to bilaterally symmetric cell divisions is regulated by Pax-mediated transcription in embryos of the leech Helobdella austinensis

The leech embryo develops by spiral cleavage, and establishes the symmetry properties of its adult body plan through the bilaterally symmetric divisions of mesodermal proteloblast DM″ and ectodermal proteloblast DNOPQ‴. We here show that transcriptional inhibitors α-amanitin and actinomycin D specif...

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Veröffentlicht in:	Developmental biology 2013-10, Vol.382 (1), p.149-159
Hauptverfasser:	Schmerer, Matthew W., Null, Ryan W., Shankland, Marty
Format:	Artikel
Sprache:	eng
Schlagworte:	actinomycin D adults alpha-amanitin Animals Blastomeres - cytology Blastomeres - metabolism Cell Count Cell Division Cytokinesis DNA DNA - metabolism Dominant-negative Ectoderm - cytology Ectoderm - embryology Embryo, Nonmammalian - cytology Embryo, Nonmammalian - metabolism evolution Gene Expression Regulation, Developmental Gene Knockdown Techniques genes Genes, Dominant Green Fluorescent Proteins - metabolism Leech embryo Leeches - cytology Leeches - embryology Leeches - metabolism Mesoderm - cytology Mesoderm - embryology Paired Box Transcription Factors - genetics Paired Box Transcription Factors - metabolism Pax gene Phenotype Protein Binding proteins RNA, Messenger - genetics RNA, Messenger - metabolism Spiral cleavage Time Factors transcription (genetics) Transcription, Genetic Zygote - cytology Zygote - metabolism Zygotic transcription
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