Characteristics of cyclosporine induction of increased prostaglandin levels from human peripheral blood monocytes

Human monocytes (M phi) exposed to 0.5-20 micrograms/ml of cyclosporine (CsA) produced levels of prostaglandins of the E series (PGE) that were 2-3-fold greater than control M phi cultured in medium alone. Maximal PGE levels were obtained at 24-48 hr incubation, and the failure to observe a linear i...

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