Active peptides from skate (Okamejei kenojei) skin gelatin diminish angiotensin-I converting enzyme activity and intracellular free radical-mediated oxidation

•Gelatin was isolated from sea food processing by-product, skate skin.•Two active peptides MVGSAPGVL (829Da) and LGPLGHQ (720Da) were isolated.•Peptides showed potent ACE inhibitory activity (IC50 3.09 and 4.22μM).•Peptides protected human endothelial cells from oxidative damage.•Peptides could be u...

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Veröffentlicht in:	Food chemistry 2014-01, Vol.143, p.246-255
Hauptverfasser:	Ngo, Dai-Hung, Ryu, BoMi, Kim, Se-Kwon
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE inhibition Amino Acid Sequence Angiotensin-Converting Enzyme Inhibitors - chemistry Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Antihypertensive Agents - chemistry Antihypertensive Agents - pharmacology Antioxidative enzymes Bioactive peptides Biological and medical sciences Cell Line Cell Survival Fish Proteins - chemistry Food toxicology Free Radical Scavengers - chemistry Free Radical Scavengers - pharmacology Gelatin - chemistry Human endothelial Human Umbilical Vein Endothelial Cells - chemistry Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - enzymology Humans Hydrolysis Kinetics Medical sciences Molecular Sequence Data Oxidation-Reduction Peptide Mapping Peptides - chemistry Peptides - isolation & purification Peptides - pharmacology Peptidyl-Dipeptidase A - chemistry Protein Hydrolysates - chemistry Protein Hydrolysates - pharmacology ROS Skate skin Skates (Fish) Skin - chemistry Subtilisins - chemistry Toxicology
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