Antiplatelet effect of AMP-activated protein kinase activator and its potentiation by the phosphodiesterase inhibitor dipyridamole

AMP-activated protein kinase (AMPK) activates endothelial nitric oxide synthase (eNOS) via phosphorylation at the activating site. The eNOS-nitric oxide (NO)/soluble guanylate cyclase (sGC)-cGMP/cGMP-dependent protein kinase (PKG) signaling axis is a major antiaggregatory mechanism residing in plate...

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Veröffentlicht in:	Biochemical pharmacology 2013-10, Vol.86 (7), p.914-925
Hauptverfasser:	Liu, Yingqiu, Oh, Seok-Jeong, Chang, Kyung-Hwa, Kim, Yoon-Gyoon, Lee, Moo-Yeol
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoimidazole Carboxamide - analogs & derivatives Aminoimidazole Carboxamide - blood Aminoimidazole Carboxamide - pharmacology AMP-activated protein kinase AMP-activated protein kinase (AMPK) AMP-Activated Protein Kinases - metabolism Animals Antiplatelet therapy Cyclic GMP - metabolism dipyridamole Dipyridamole - pharmacology Disease Models, Animal endothelial nitric oxide synthase Enzyme Activation - drug effects Enzyme Activators - pharmacology guanylate cyclase Male Nitric Oxide Synthase Type III - metabolism pharmacology Phosphodiesterase Inhibitors - pharmacology phosphorylation Phosphorylation - drug effects Platelet aggregation Platelet Aggregation Inhibitors - pharmacology Rats Rats, Sprague-Dawley Ribonucleotides - blood Ribonucleotides - pharmacology signal transduction Signal Transduction - drug effects therapeutics Thrombosis - drug therapy Thrombosis - metabolism Thrombosis 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR)
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