TFE3 Controls Lipid Metabolism in Adipose Tissue of Male Mice by Suppressing Lipolysis and Thermogenesis

Transcription factor E3 (TFE3) is a transcription factor that binds to E-box motifs and promotes energy metabolism-related genes. We previously reported that TFE3 directly binds to the insulin receptor substrate-2 promoter in the liver, resulting in increased insulin response. However, the role of T...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2013-10, Vol.154 (10), p.3577-3588
Hauptverfasser:	Fujimoto, Yuri, Nakagawa, Yoshimi, Satoh, Aoi, Okuda, Kanako, Shingyouchi, Akiko, Naka, Ayano, Matsuzaka, Takashi, Iwasaki, Hitoshi, Kobayashi, Kazuto, Yahagi, Naoya, Shimada, Masako, Yatoh, Shigeru, Suzuki, Hiroaki, Yogosawa, Satomi, Izumi, Tetsuro, Sone, Hirohito, Urayama, Osamu, Yamada, Nobuhiro, Shimano, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipogenesis Adipose tissue Adipose tissue (brown) Adipose Tissue, Brown - metabolism Adipose Tissue, Brown - pathology Adipose Tissue, White - enzymology Adipose Tissue, White - metabolism Adipose Tissue, White - pathology Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - biosynthesis Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism Biological and medical sciences Body fat Carrier Proteins - biosynthesis Carrier Proteins - genetics Carrier Proteins - metabolism Cell Cycle Proteins - biosynthesis Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cells, Cultured Down-Regulation Energy metabolism Fatty Acid-Binding Proteins - genetics Fatty Acid-Binding Proteins - metabolism Forkhead Box Protein O1 Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism FOXO1 protein Fundamental and applied biological sciences. Psychology Gene expression Genes Insulin Ion Channels - genetics Ion Channels - metabolism Lipase Lipase - genetics Lipase - metabolism Lipid metabolism Lipids Lipolysis Male Metabolism Mice Mice, Transgenic Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Obesity - enzymology Obesity - metabolism Obesity - pathology Perilipin-1 Phosphoproteins - biosynthesis Phosphoproteins - genetics Phosphoproteins - metabolism Promoter Regions, Genetic Recombinant Proteins - biosynthesis Recombinant Proteins - metabolism Thermogenesis Transcription factors Transgenic animals Transgenic mice Triglycerides Uncoupling Protein 1 Vertebrates: endocrinology
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