Heart failure and chronic obstructive pulmonary disease: the challenges facing physicians and health services
Pulmonary disease is common in patients with heart failure, through shared risk factors and pathophysiological mechanisms. Adverse pulmonary vascular remodelling and chronic systemic inflammation characterize both diseases. Concurrent chronic obstructive pulmonary disease presents diagnostic and the...
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| Veröffentlicht in: | European heart journal 2013-09, Vol.34 (36), p.2795-2807 |
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| container_end_page | 2807 |
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| container_title | European heart journal |
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| creator | Hawkins, Nathaniel M Virani, Sean Ceconi, Claudio |
| description | Pulmonary disease is common in patients with heart failure, through shared risk factors and pathophysiological mechanisms. Adverse pulmonary vascular remodelling and chronic systemic inflammation characterize both diseases. Concurrent chronic obstructive pulmonary disease presents diagnostic and therapeutic challenges, and is associated with increased morbidity and mortality. The cornerstones of therapy are beta-blockers and beta-agonists, whose pharmacological properties are diametrically opposed. Each disease is implicated in exacerbations of the other condition, greatly increasing hospitalizations and associated health care costs. Such multimorbidity is a key challenge for health-care systems oriented towards the treatment of individual diseases. Early identification and treatment of cardiopulmonary disease may alleviate this burden. However, diagnostic and therapeutic strategies require further validation in patients with both conditions. |
| doi_str_mv | 10.1093/eurheartj/eht192 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0195-668X |
| ispartof | European heart journal, 2013-09, Vol.34 (36), p.2795-2807 |
| issn | 0195-668X 1522-9645 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adrenergic beta-Agonists - therapeutic use Adrenergic beta-Antagonists - therapeutic use Costs and Cost Analysis Diagnosis, Differential Drug Therapy, Combination Early Diagnosis Echocardiography Genetic Predisposition to Disease - genetics Heart Failure - complications Heart Failure - diagnosis Heart Failure - drug therapy Humans Natriuretic Peptides - metabolism Practice Guidelines as Topic Prognosis Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - drug therapy Randomized Controlled Trials as Topic Respiratory Function Tests Risk Factors |
| title | Heart failure and chronic obstructive pulmonary disease: the challenges facing physicians and health services |
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