Integrin α6β1 Is the Main Receptor for Vascular Laminins and Plays a Role in Platelet Adhesion, Activation, and Arterial Thrombosis

BACKGROUND—Laminins are major components of basement membranes, well located to interact with platelets upon vascular injury. Laminin-111 (α1β1γ1) is known to support platelet adhesion but is absent from most blood vessels, which contain isoforms with the α2, α4, or α5 chain. Whether vascular lamini...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2013-07, Vol.128 (5), p.541-552
Hauptverfasser:	Schaff, Mathieu, Tang, ChaoJun, Maurer, Eric, Bourdon, Catherine, Receveur, Nicolas, Eckly, Anita, Hechler, Béatrice, Arnold, Christiane, de Arcangelis, Adèle, Nieswandt, Bernhard, Denis, Cécile V, Lefebvre, Olivier, Georges-Labouesse, Elisabeth, Gachet, Christian, Lanza, François, Mangin, Pierre H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - metabolism Aorta - pathology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Carotid Arteries - metabolism Carotid Arteries - pathology Cell Adhesion - physiology Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Humans Integrin alpha6beta1 - metabolism Integrin alpha6beta1 - physiology Laminin - physiology Medical sciences Mesenteric Arteries - metabolism Mesenteric Arteries - pathology Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Platelet Activation - physiology Platelet Adhesiveness - physiology Risk Factors Thrombosis - metabolism Thrombosis - pathology
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