The Effective Concentration of Tranexamic Acid for Inhibition of Fibrinolysis in Neonatal Plasma In Vitro

BACKGROUND:Neonates are at high risk for bleeding complications after cardiovascular surgery. Activation of intravascular fibrinolysis is one of the principal effects of cardiopulmonary bypass that causes poor postoperative hemostasis. Antifibrinolytic medications such as tranexamic acid are often u...

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Veröffentlicht in:	Anesthesia and analgesia 2013-10, Vol.117 (4), p.767-772
Hauptverfasser:	Yee, Branden E., Wissler, Richard N., Zanghi, Christine N., Feng, Changyong, Eaton, Michael P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifibrinolytic Agents - blood Antifibrinolytic Agents - pharmacology Antifibrinolytic Agents - therapeutic use Fetal Blood - drug effects Fetal Blood - metabolism Fibrinolysis - drug effects Fibrinolysis - physiology Humans Infant, Newborn Tranexamic Acid - blood Tranexamic Acid - pharmacology Tranexamic Acid - therapeutic use Treatment Outcome
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