Reciprocal Expression of Enteric Antimicrobial Proteins in Intestinal Graft-Versus-Host Disease
Abstract We recently demonstrated that expression of α-defensins, the major antimicrobial peptides produced by Paneth cells, was severely suppressed in mice with graft-versus-host disease (GVHD). In this study, we found that antibacterial lectin, regenerating islet-derived IIIγ (RegIIIγ) was upregul...
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| Veröffentlicht in: | Biology of blood and marrow transplantation 2013-10, Vol.19 (10), p.1525-1529 |
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| container_title | Biology of blood and marrow transplantation |
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| creator | Eriguchi, Yoshihiro Uryu, Hidetaka Nakamura, Kiminori Shimoji, Sonoko Takashima, Shuichiro Iwasaki, Hiromi Miyamoto, Toshihiro Shimono, Nobuyuki Hashimoto, Daigo Akashi, Koichi Ayabe, Tokiyoshi Teshima, Takanori |
| description | Abstract We recently demonstrated that expression of α-defensins, the major antimicrobial peptides produced by Paneth cells, was severely suppressed in mice with graft-versus-host disease (GVHD). In this study, we found that antibacterial lectin, regenerating islet-derived IIIγ (RegIIIγ) was upregulated in villous enterocytes, thus demonstrating the reciprocal control of enteric antimicrobial proteins in GVHD. Upregulation of RegIIIγ was mediated by a mechanism independent upon radiation-induced intestinal tract damage. MyD88-mediated signaling in intestinal epithelium was required for RegIIIγ upregulation in GVHD and antibiotic therapy downregulated RegIIIγ expression. These results suggest that MyD88-mediated sensing of the intestinal microbes disregulated in GVHD induces RegIIIγ upregulation in GVHD and argue a role for RegIIIγ in the pathogenesis of GVHD. |
| doi_str_mv | 10.1016/j.bbmt.2013.07.027 |
| format | Article |
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In this study, we found that antibacterial lectin, regenerating islet-derived IIIγ (RegIIIγ) was upregulated in villous enterocytes, thus demonstrating the reciprocal control of enteric antimicrobial proteins in GVHD. Upregulation of RegIIIγ was mediated by a mechanism independent upon radiation-induced intestinal tract damage. MyD88-mediated signaling in intestinal epithelium was required for RegIIIγ upregulation in GVHD and antibiotic therapy downregulated RegIIIγ expression. These results suggest that MyD88-mediated sensing of the intestinal microbes disregulated in GVHD induces RegIIIγ upregulation in GVHD and argue a role for RegIIIγ in the pathogenesis of GVHD.</description><identifier>ISSN: 1083-8791</identifier><identifier>EISSN: 1523-6536</identifier><identifier>DOI: 10.1016/j.bbmt.2013.07.027</identifier><identifier>PMID: 23927965</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Antimicrobial Cationic Peptides - biosynthesis ; Defensins ; Female ; Graft vs Host Disease - etiology ; Graft vs Host Disease - metabolism ; Graft-versus-host disease ; Hematology, Oncology and Palliative Medicine ; Hematopoietic stem cell transplantation ; Hematopoietic Stem Cell Transplantation - methods ; Intestinal Mucosa - metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Regenerating islet-derived III ; Toll-like receptors ; Transplantation Conditioning - methods ; Transplantation, Homologous</subject><ispartof>Biology of blood and marrow transplantation, 2013-10, Vol.19 (10), p.1525-1529</ispartof><rights>American Society for Blood and Marrow Transplantation</rights><rights>2013 American Society for Blood and Marrow Transplantation</rights><rights>Copyright © 2013 American Society for Blood and Marrow Transplantation. 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In this study, we found that antibacterial lectin, regenerating islet-derived IIIγ (RegIIIγ) was upregulated in villous enterocytes, thus demonstrating the reciprocal control of enteric antimicrobial proteins in GVHD. Upregulation of RegIIIγ was mediated by a mechanism independent upon radiation-induced intestinal tract damage. MyD88-mediated signaling in intestinal epithelium was required for RegIIIγ upregulation in GVHD and antibiotic therapy downregulated RegIIIγ expression. These results suggest that MyD88-mediated sensing of the intestinal microbes disregulated in GVHD induces RegIIIγ upregulation in GVHD and argue a role for RegIIIγ in the pathogenesis of GVHD.</description><subject>Animals</subject><subject>Antimicrobial Cationic Peptides - biosynthesis</subject><subject>Defensins</subject><subject>Female</subject><subject>Graft vs Host Disease - etiology</subject><subject>Graft vs Host Disease - metabolism</subject><subject>Graft-versus-host disease</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hematopoietic stem cell transplantation</subject><subject>Hematopoietic Stem Cell Transplantation - methods</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Regenerating islet-derived III</subject><subject>Toll-like receptors</subject><subject>Transplantation Conditioning - methods</subject><subject>Transplantation, Homologous</subject><issn>1083-8791</issn><issn>1523-6536</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1TAQhS0EouXCH2CBsmSTMH7FNxJCqsqlrVSJqjy2luNMJF_yuHiciv57HN3CoouuxrLOGc35DmNvOVQceP1hX7XtmCoBXFZgKhDmGTvlWsiy1rJ-nt-wleXWNPyEvSLaA4BR2-YlOxGyEaap9Smzt-jDIc7eDcXuzyEiUZinYu6L3ZQwBl-cTSmMwce5DVlzE-eEYaIiTMVVVlAKU_6-iK5P5U-MtFB5OVMqPgdCR_iavejdQPjmYW7Yjy-77-eX5fXXi6vzs-vS61qnsjXQOeE755zX3IAAqJteIXLRNQCi19K1vW4F973mHjupnNJOiQ6c4K6VG_b-uDdn-b3ks-wYyOMwuAnnhSxXUhlVqzw3TBylORNRxN4eYhhdvLcc7ArW7u0K1q5gLRibwWbTu4f9Szti99_yj2QWfDwKMKe8Cxgt-YBTPjVE9Ml2c3h6_6dHdj-EKeRafuE90n5eYuacc1gSFuy3tdq1WS4BpGqE_Avx95_e</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Eriguchi, Yoshihiro</creator><creator>Uryu, Hidetaka</creator><creator>Nakamura, Kiminori</creator><creator>Shimoji, Sonoko</creator><creator>Takashima, Shuichiro</creator><creator>Iwasaki, Hiromi</creator><creator>Miyamoto, Toshihiro</creator><creator>Shimono, Nobuyuki</creator><creator>Hashimoto, Daigo</creator><creator>Akashi, Koichi</creator><creator>Ayabe, Tokiyoshi</creator><creator>Teshima, Takanori</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131001</creationdate><title>Reciprocal Expression of Enteric Antimicrobial Proteins in Intestinal Graft-Versus-Host Disease</title><author>Eriguchi, Yoshihiro ; 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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Antimicrobial Cationic Peptides - biosynthesis Defensins Female Graft vs Host Disease - etiology Graft vs Host Disease - metabolism Graft-versus-host disease Hematology, Oncology and Palliative Medicine Hematopoietic stem cell transplantation Hematopoietic Stem Cell Transplantation - methods Intestinal Mucosa - metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Regenerating islet-derived III Toll-like receptors Transplantation Conditioning - methods Transplantation, Homologous |
| title | Reciprocal Expression of Enteric Antimicrobial Proteins in Intestinal Graft-Versus-Host Disease |
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