The D-repeat polymorphism in the ASPN gene and primary knee osteoarthritis in a Mexican mestizo population: a case–control study
A genetic association between osteoarthritis (OA) and a polymorphism in the aspartic acid (D) repeat of the asporin (ASPN) gene has been reported in Japanese, Han Chinese, Greek and UK Caucasian populations of patients having knee and hip OA. Such an association has not been previously described amo...
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| Veröffentlicht in: | Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2013-09, Vol.18 (5), p.826-831 |
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| container_title | Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association |
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| creator | Arellano, R.D. Arguello, J.R. Velasco, V.M. Loera, C.R. Hernández, F. García-Sepúlveda, C.A. |
| description | A genetic association between osteoarthritis (OA) and a polymorphism in the aspartic acid (D) repeat of the asporin (ASPN) gene has been reported in Japanese, Han Chinese, Greek and UK Caucasian populations of patients having knee and hip OA. Such an association has not been previously described among the Mexican mestizo population. The aim of this study was to analyze the association of the ASPN gene D-repeat polymorphism in a Mexican mestizo population with primary knee OA as well as in healthy controls.
A case–control study was conducted on a Mexican mestizo population of northern Mexico. The repeat polymorphism was genotyped in 440 subjects (218 cases and 222 healthy controls). Primary knee OA was diagnosed according to American College of Rheumatology and Kellgren-Lawrence criteria, and allelic association was examined adjusting for other risk variables.
After adjusting for some covariates, menopause and the D16 allele showed a trend toward being risk factors for knee OA in a Mexican mestizo population. Also, the D12 allele could be considered as a protective factor.
These findings suggest that polymorphisms within the ASPN gene could influence knee OA susceptibility, but these associations must be confirmed by independent studies in larger samples and different ethnic groups to support the role of the D-repeat polymorphism in the ASPN gene as risk or protection factors for knee OA in a Mexican population. |
| doi_str_mv | 10.1007/s00776-013-0414-1 |
| format | Article |
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A case–control study was conducted on a Mexican mestizo population of northern Mexico. The repeat polymorphism was genotyped in 440 subjects (218 cases and 222 healthy controls). Primary knee OA was diagnosed according to American College of Rheumatology and Kellgren-Lawrence criteria, and allelic association was examined adjusting for other risk variables.
After adjusting for some covariates, menopause and the D16 allele showed a trend toward being risk factors for knee OA in a Mexican mestizo population. Also, the D12 allele could be considered as a protective factor.
These findings suggest that polymorphisms within the ASPN gene could influence knee OA susceptibility, but these associations must be confirmed by independent studies in larger samples and different ethnic groups to support the role of the D-repeat polymorphism in the ASPN gene as risk or protection factors for knee OA in a Mexican population.</description><identifier>ISSN: 0949-2658</identifier><identifier>EISSN: 1436-2023</identifier><identifier>DOI: 10.1007/s00776-013-0414-1</identifier><identifier>PMID: 23733110</identifier><language>eng</language><publisher>Tokyo: Elsevier B.V</publisher><subject>Case-Control Studies ; Extracellular Matrix Proteins - genetics ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Mexico ; Middle Aged ; Original Article ; Orthopedics ; Osteoarthritis, Knee - genetics ; Polymorphism, Genetic ; Rheumatology</subject><ispartof>Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2013-09, Vol.18 (5), p.826-831</ispartof><rights>2013 The Japanese Orthopaedic Association</rights><rights>The Japanese Orthopaedic Association 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-67e4b184e204ffdb0a28032d6c125193f83864eddfe290b5d58087731f8b28343</citedby><cites>FETCH-LOGICAL-c448t-67e4b184e204ffdb0a28032d6c125193f83864eddfe290b5d58087731f8b28343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00776-013-0414-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00776-013-0414-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23733110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arellano, R.D.</creatorcontrib><creatorcontrib>Arguello, J.R.</creatorcontrib><creatorcontrib>Velasco, V.M.</creatorcontrib><creatorcontrib>Loera, C.R.</creatorcontrib><creatorcontrib>Hernández, F.</creatorcontrib><creatorcontrib>García-Sepúlveda, C.A.</creatorcontrib><title>The D-repeat polymorphism in the ASPN gene and primary knee osteoarthritis in a Mexican mestizo population: a case–control study</title><title>Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association</title><addtitle>J Orthop Sci</addtitle><addtitle>J Orthop Sci</addtitle><description>A genetic association between osteoarthritis (OA) and a polymorphism in the aspartic acid (D) repeat of the asporin (ASPN) gene has been reported in Japanese, Han Chinese, Greek and UK Caucasian populations of patients having knee and hip OA. Such an association has not been previously described among the Mexican mestizo population. The aim of this study was to analyze the association of the ASPN gene D-repeat polymorphism in a Mexican mestizo population with primary knee OA as well as in healthy controls.
A case–control study was conducted on a Mexican mestizo population of northern Mexico. The repeat polymorphism was genotyped in 440 subjects (218 cases and 222 healthy controls). Primary knee OA was diagnosed according to American College of Rheumatology and Kellgren-Lawrence criteria, and allelic association was examined adjusting for other risk variables.
After adjusting for some covariates, menopause and the D16 allele showed a trend toward being risk factors for knee OA in a Mexican mestizo population. Also, the D12 allele could be considered as a protective factor.
These findings suggest that polymorphisms within the ASPN gene could influence knee OA susceptibility, but these associations must be confirmed by independent studies in larger samples and different ethnic groups to support the role of the D-repeat polymorphism in the ASPN gene as risk or protection factors for knee OA in a Mexican population.</description><subject>Case-Control Studies</subject><subject>Extracellular Matrix Proteins - genetics</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mexico</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteoarthritis, Knee - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Rheumatology</subject><issn>0949-2658</issn><issn>1436-2023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1u1DAUhS0EokPhAdggS2zYBPyXxIFVVX6l8iNR1pZj33RcEju1HcSwQrwCb8iT4FEGhFh047u43zm-Ogeh-5Q8poS0T1J52qYilFdEUFHRG2hDBW8qRhi_iTakE13FmloeoTspXRJC27qrb6MjxlvOKSUb9ON8C_h5FWEGnfEcxt0U4rx1acLO41yWJx8_vMMX4AFrb_Ec3aTjDn_2ADikDEHHvI0uu7QXaPwWvjqjPZ4gZfctFMt5GXV2wT8tW6MT_Pr-0wSfYxhxyovd3UW3Bj0muHeYx-jTyxfnp6-rs_ev3pyenFVGCJmrpgXRUymAETEMtieaScKZbQxlNe34ILlsBFg7AOtIX9taEtm2nA6yZ5ILfowerb5zDFdLOU9NLhkYR-0hLEmV5EQrRNfKgj78D70MS_Tluj3FO9nRri4UXSkTQ0oRBnVIR1Gi9gWptSBVClL7ghQtmgcH56WfwP5V_GmkAGwFUln5C4j_fH2N67NVBCW_L66IknHgDVgXwWRlg7tG_RuWXa8l</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Arellano, R.D.</creator><creator>Arguello, J.R.</creator><creator>Velasco, V.M.</creator><creator>Loera, C.R.</creator><creator>Hernández, F.</creator><creator>García-Sepúlveda, C.A.</creator><general>Elsevier B.V</general><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130901</creationdate><title>The D-repeat polymorphism in the ASPN gene and primary knee osteoarthritis in a Mexican mestizo population: a case–control study</title><author>Arellano, R.D. ; Arguello, J.R. ; Velasco, V.M. ; Loera, C.R. ; Hernández, F. ; García-Sepúlveda, C.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-67e4b184e204ffdb0a28032d6c125193f83864eddfe290b5d58087731f8b28343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Case-Control Studies</topic><topic>Extracellular Matrix Proteins - genetics</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mexico</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteoarthritis, Knee - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Rheumatology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arellano, R.D.</creatorcontrib><creatorcontrib>Arguello, J.R.</creatorcontrib><creatorcontrib>Velasco, V.M.</creatorcontrib><creatorcontrib>Loera, C.R.</creatorcontrib><creatorcontrib>Hernández, F.</creatorcontrib><creatorcontrib>García-Sepúlveda, C.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arellano, R.D.</au><au>Arguello, J.R.</au><au>Velasco, V.M.</au><au>Loera, C.R.</au><au>Hernández, F.</au><au>García-Sepúlveda, C.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The D-repeat polymorphism in the ASPN gene and primary knee osteoarthritis in a Mexican mestizo population: a case–control study</atitle><jtitle>Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association</jtitle><stitle>J Orthop Sci</stitle><addtitle>J Orthop Sci</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>18</volume><issue>5</issue><spage>826</spage><epage>831</epage><pages>826-831</pages><issn>0949-2658</issn><eissn>1436-2023</eissn><abstract>A genetic association between osteoarthritis (OA) and a polymorphism in the aspartic acid (D) repeat of the asporin (ASPN) gene has been reported in Japanese, Han Chinese, Greek and UK Caucasian populations of patients having knee and hip OA. Such an association has not been previously described among the Mexican mestizo population. The aim of this study was to analyze the association of the ASPN gene D-repeat polymorphism in a Mexican mestizo population with primary knee OA as well as in healthy controls.
A case–control study was conducted on a Mexican mestizo population of northern Mexico. The repeat polymorphism was genotyped in 440 subjects (218 cases and 222 healthy controls). Primary knee OA was diagnosed according to American College of Rheumatology and Kellgren-Lawrence criteria, and allelic association was examined adjusting for other risk variables.
After adjusting for some covariates, menopause and the D16 allele showed a trend toward being risk factors for knee OA in a Mexican mestizo population. Also, the D12 allele could be considered as a protective factor.
These findings suggest that polymorphisms within the ASPN gene could influence knee OA susceptibility, but these associations must be confirmed by independent studies in larger samples and different ethnic groups to support the role of the D-repeat polymorphism in the ASPN gene as risk or protection factors for knee OA in a Mexican population.</abstract><cop>Tokyo</cop><pub>Elsevier B.V</pub><pmid>23733110</pmid><doi>10.1007/s00776-013-0414-1</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2013-09, Vol.18 (5), p.826-831 |
| issn | 0949-2658 1436-2023 |
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| subjects | Case-Control Studies Extracellular Matrix Proteins - genetics Female Humans Male Medicine Medicine & Public Health Mexico Middle Aged Original Article Orthopedics Osteoarthritis, Knee - genetics Polymorphism, Genetic Rheumatology |
| title | The D-repeat polymorphism in the ASPN gene and primary knee osteoarthritis in a Mexican mestizo population: a case–control study |
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