Comparison between a second and a third generation parathyroid hormone assay in hemodialysis patients
Abstract Objective Third generation parathyroid hormone (PTH) assays are new generation assays that do not recognize the PTH7–84 fragment whereas second generation assays detect both PTH1–84 and PTH7–84 fragments. Despite the excellent correlation between both assays in chronic renal failure (CRF) s...
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| description | Abstract Objective Third generation parathyroid hormone (PTH) assays are new generation assays that do not recognize the PTH7–84 fragment whereas second generation assays detect both PTH1–84 and PTH7–84 fragments. Despite the excellent correlation between both assays in chronic renal failure (CRF) subjects, the mean PTH levels are typically 50% lower with the third compared to the second generation assays. The assessment of third generation PTH assays has not been extensively studied in hemodialysis subjects. The purpose of our study was to compare a third generation PTH assay to a second generation one in a population of hemodialysis subjects. Materials and methods 92 haemodialysis subjects (36 women and 56 men) with a mean age of 67±12.9 years were included in this study. Anthropometric and clinical parameters (Body Mass Index (BMI) and blood pressure) were measured. Second and third generation PTH assays (Cis biomedical and Diasorin respectively) were performed in each subject. In addition, the following biochemical tests were measured: 25-hydroxyvitamin D (25-(OH)D), 1,25-hydroxyvitamin D (1,25-(OH)2 D), crosslaps and alkaline phosphatase. Results The mean second and third generation PTHs are respectively 211±205 pg/ml and 151±164 pg/ml. The mean third generation PTH values are 28.4% lower compared to the second generation ones. Both methods are strongly correlated (r = 0.923, p < 0.001). This correlation persisted without any significant difference after controlling for gender, age, BMI and Blood Pressure. However, the difference between both methods increases when baseline PTH increases. Each of the second and third generation method is significantly correlated with hemodialysis duration (p < 0.01), crosslaps (p < 0.001), alkaline phosphatase (p < 0.05), but not with age, BMI, Blood Pressure, 25-(OH)D or 1,25-(OH)2 D levels. Conclusion Our results show that both second and third generation PTH methods are strongly correlated in hemodialysis patients mainly when PTH values are low. However, the difference between both methods increases when PTH values are high. More research is needed to establish which method is the gold standard when PTH values are high. |
| doi_str_mv | 10.1016/j.metabol.2013.05.007 |
| format | Article |
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Despite the excellent correlation between both assays in chronic renal failure (CRF) subjects, the mean PTH levels are typically 50% lower with the third compared to the second generation assays. The assessment of third generation PTH assays has not been extensively studied in hemodialysis subjects. The purpose of our study was to compare a third generation PTH assay to a second generation one in a population of hemodialysis subjects. Materials and methods 92 haemodialysis subjects (36 women and 56 men) with a mean age of 67±12.9 years were included in this study. Anthropometric and clinical parameters (Body Mass Index (BMI) and blood pressure) were measured. Second and third generation PTH assays (Cis biomedical and Diasorin respectively) were performed in each subject. In addition, the following biochemical tests were measured: 25-hydroxyvitamin D (25-(OH)D), 1,25-hydroxyvitamin D (1,25-(OH)2 D), crosslaps and alkaline phosphatase. Results The mean second and third generation PTHs are respectively 211±205 pg/ml and 151±164 pg/ml. The mean third generation PTH values are 28.4% lower compared to the second generation ones. Both methods are strongly correlated (r = 0.923, p < 0.001). This correlation persisted without any significant difference after controlling for gender, age, BMI and Blood Pressure. However, the difference between both methods increases when baseline PTH increases. Each of the second and third generation method is significantly correlated with hemodialysis duration (p < 0.01), crosslaps (p < 0.001), alkaline phosphatase (p < 0.05), but not with age, BMI, Blood Pressure, 25-(OH)D or 1,25-(OH)2 D levels. Conclusion Our results show that both second and third generation PTH methods are strongly correlated in hemodialysis patients mainly when PTH values are low. However, the difference between both methods increases when PTH values are high. More research is needed to establish which method is the gold standard when PTH values are high.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/j.metabol.2013.05.007</identifier><identifier>PMID: 23769129</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Alkaline Phosphatase - blood ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Pressure - drug effects ; Body Mass Index ; Bone Diseases, Metabolic - blood ; Collagen - blood ; Emergency and intensive care: renal failure. Dialysis management ; Endocrinology & Metabolism ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Hemodialysis ; Humans ; Intensive care medicine ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - physiopathology ; Kidney Failure, Chronic - therapy ; Male ; Medical sciences ; Parathyroid hormone ; Parathyroid Hormone - blood ; Peptide Fragments - blood ; Renal Dialysis ; Second ; Statistics as Topic ; Third generation ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin D - analogs & derivatives ; Vitamin D - blood</subject><ispartof>Metabolism, clinical and experimental, 2013-10, Vol.62 (10), p.1416-1422</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-f381a31af25a71fcb2ccb7982cd846249f875a371046ae5972c8ad5bfa6701a03</citedby><cites>FETCH-LOGICAL-c450t-f381a31af25a71fcb2ccb7982cd846249f875a371046ae5972c8ad5bfa6701a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.metabol.2013.05.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27770846$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23769129$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gannagé-Yared, Marie-Hélène</creatorcontrib><creatorcontrib>Farès, Chirine</creatorcontrib><creatorcontrib>Ibrahim, Tony</creatorcontrib><creatorcontrib>Rahal, Zeina Abou</creatorcontrib><creatorcontrib>Elias, Michele</creatorcontrib><creatorcontrib>Chelala, Dania</creatorcontrib><title>Comparison between a second and a third generation parathyroid hormone assay in hemodialysis patients</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>Abstract Objective Third generation parathyroid hormone (PTH) assays are new generation assays that do not recognize the PTH7–84 fragment whereas second generation assays detect both PTH1–84 and PTH7–84 fragments. Despite the excellent correlation between both assays in chronic renal failure (CRF) subjects, the mean PTH levels are typically 50% lower with the third compared to the second generation assays. The assessment of third generation PTH assays has not been extensively studied in hemodialysis subjects. The purpose of our study was to compare a third generation PTH assay to a second generation one in a population of hemodialysis subjects. Materials and methods 92 haemodialysis subjects (36 women and 56 men) with a mean age of 67±12.9 years were included in this study. Anthropometric and clinical parameters (Body Mass Index (BMI) and blood pressure) were measured. Second and third generation PTH assays (Cis biomedical and Diasorin respectively) were performed in each subject. In addition, the following biochemical tests were measured: 25-hydroxyvitamin D (25-(OH)D), 1,25-hydroxyvitamin D (1,25-(OH)2 D), crosslaps and alkaline phosphatase. Results The mean second and third generation PTHs are respectively 211±205 pg/ml and 151±164 pg/ml. The mean third generation PTH values are 28.4% lower compared to the second generation ones. Both methods are strongly correlated (r = 0.923, p < 0.001). This correlation persisted without any significant difference after controlling for gender, age, BMI and Blood Pressure. However, the difference between both methods increases when baseline PTH increases. Each of the second and third generation method is significantly correlated with hemodialysis duration (p < 0.01), crosslaps (p < 0.001), alkaline phosphatase (p < 0.05), but not with age, BMI, Blood Pressure, 25-(OH)D or 1,25-(OH)2 D levels. Conclusion Our results show that both second and third generation PTH methods are strongly correlated in hemodialysis patients mainly when PTH values are low. However, the difference between both methods increases when PTH values are high. More research is needed to establish which method is the gold standard when PTH values are high.</description><subject>Aged</subject><subject>Alkaline Phosphatase - blood</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Body Mass Index</subject><subject>Bone Diseases, Metabolic - blood</subject><subject>Collagen - blood</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Endocrinology & Metabolism</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - physiopathology</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Parathyroid hormone</subject><subject>Parathyroid Hormone - blood</subject><subject>Peptide Fragments - blood</subject><subject>Renal Dialysis</subject><subject>Second</subject><subject>Statistics as Topic</subject><subject>Third generation</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2P0zAQQCMEYrsLPwHkCxKXlLETx8kFtKpgQVqJA3C2Js6EuiR2sV1Q_j2OWkDiwmE0lzdfT1MUzzhsOfDm1WE7U8LeT1sBvNqC3AKoB8WGy0qUbQPwsNgAiKaEupNXxXWMB8iEapvHxZWoVNNx0W0K2vn5iMFG71hP6SeRY8giGe8GhmuwtLdhYF_JUcBkM5d5TPsleDuwvQ-zd8QwRlyYdWxPsx8sTku0MZPJkkvxSfFoxCnS00u-Kb68e_t59768_3j3YXd7X5paQirHquVYcRyFRMVH0wtjetW1wgxt3Yi6G1slsVIc6gZJdkqYFgfZj9go4AjVTfHy3PcY_PcTxaRnGw1NEzryp6h5XdWqFk2tMirPqAk-xkCjPgY7Y1g0B70a1gd9MaxXwxqkzv5y3fPLiFM_0_Cn6rfSDLy4ABgNTmNAZ2z8yymlIF-TuTdnjrKQH5aCjibLMjTYQCbpwdv_rvL6nw5mss7mod9ooXjwp-Cybc11FBr0p_Ud1m_gFQCvW6h-AaWVsj4</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Gannagé-Yared, Marie-Hélène</creator><creator>Farès, Chirine</creator><creator>Ibrahim, Tony</creator><creator>Rahal, Zeina Abou</creator><creator>Elias, Michele</creator><creator>Chelala, Dania</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131001</creationdate><title>Comparison between a second and a third generation parathyroid hormone assay in hemodialysis patients</title><author>Gannagé-Yared, Marie-Hélène ; Farès, Chirine ; Ibrahim, Tony ; Rahal, Zeina Abou ; Elias, Michele ; Chelala, Dania</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-f381a31af25a71fcb2ccb7982cd846249f875a371046ae5972c8ad5bfa6701a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Alkaline Phosphatase - blood</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Body Mass Index</topic><topic>Bone Diseases, Metabolic - blood</topic><topic>Collagen - blood</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Endocrinology & Metabolism</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hemodialysis</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Failure, Chronic - physiopathology</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Parathyroid hormone</topic><topic>Parathyroid Hormone - blood</topic><topic>Peptide Fragments - blood</topic><topic>Renal Dialysis</topic><topic>Second</topic><topic>Statistics as Topic</topic><topic>Third generation</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gannagé-Yared, Marie-Hélène</creatorcontrib><creatorcontrib>Farès, Chirine</creatorcontrib><creatorcontrib>Ibrahim, Tony</creatorcontrib><creatorcontrib>Rahal, Zeina Abou</creatorcontrib><creatorcontrib>Elias, Michele</creatorcontrib><creatorcontrib>Chelala, Dania</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gannagé-Yared, Marie-Hélène</au><au>Farès, Chirine</au><au>Ibrahim, Tony</au><au>Rahal, Zeina Abou</au><au>Elias, Michele</au><au>Chelala, Dania</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison between a second and a third generation parathyroid hormone assay in hemodialysis patients</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>62</volume><issue>10</issue><spage>1416</spage><epage>1422</epage><pages>1416-1422</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>Abstract Objective Third generation parathyroid hormone (PTH) assays are new generation assays that do not recognize the PTH7–84 fragment whereas second generation assays detect both PTH1–84 and PTH7–84 fragments. Despite the excellent correlation between both assays in chronic renal failure (CRF) subjects, the mean PTH levels are typically 50% lower with the third compared to the second generation assays. The assessment of third generation PTH assays has not been extensively studied in hemodialysis subjects. The purpose of our study was to compare a third generation PTH assay to a second generation one in a population of hemodialysis subjects. Materials and methods 92 haemodialysis subjects (36 women and 56 men) with a mean age of 67±12.9 years were included in this study. Anthropometric and clinical parameters (Body Mass Index (BMI) and blood pressure) were measured. Second and third generation PTH assays (Cis biomedical and Diasorin respectively) were performed in each subject. In addition, the following biochemical tests were measured: 25-hydroxyvitamin D (25-(OH)D), 1,25-hydroxyvitamin D (1,25-(OH)2 D), crosslaps and alkaline phosphatase. Results The mean second and third generation PTHs are respectively 211±205 pg/ml and 151±164 pg/ml. The mean third generation PTH values are 28.4% lower compared to the second generation ones. Both methods are strongly correlated (r = 0.923, p < 0.001). This correlation persisted without any significant difference after controlling for gender, age, BMI and Blood Pressure. However, the difference between both methods increases when baseline PTH increases. Each of the second and third generation method is significantly correlated with hemodialysis duration (p < 0.01), crosslaps (p < 0.001), alkaline phosphatase (p < 0.05), but not with age, BMI, Blood Pressure, 25-(OH)D or 1,25-(OH)2 D levels. Conclusion Our results show that both second and third generation PTH methods are strongly correlated in hemodialysis patients mainly when PTH values are low. However, the difference between both methods increases when PTH values are high. More research is needed to establish which method is the gold standard when PTH values are high.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>23769129</pmid><doi>10.1016/j.metabol.2013.05.007</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Alkaline Phosphatase - blood Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Pressure - drug effects Body Mass Index Bone Diseases, Metabolic - blood Collagen - blood Emergency and intensive care: renal failure. Dialysis management Endocrinology & Metabolism Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Hemodialysis Humans Intensive care medicine Kidney Failure, Chronic - blood Kidney Failure, Chronic - physiopathology Kidney Failure, Chronic - therapy Male Medical sciences Parathyroid hormone Parathyroid Hormone - blood Peptide Fragments - blood Renal Dialysis Second Statistics as Topic Third generation Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin D - analogs & derivatives Vitamin D - blood |
| title | Comparison between a second and a third generation parathyroid hormone assay in hemodialysis patients |
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