Treatment of recurrent genital herpes simplex infections with oral acyclovir
A total of 113 patients with recurrent genital herpes were enrolled in a multicentre cross-over study. Two consecutive recurrences were treated with either oral acyclovir 200 mg or matching placebo five times daily for five days. Acyclovir significantly reduced the time to crusting and healing and t...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 1985-11, Vol.16 (5), p.621-628 |
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| container_end_page | 628 |
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| container_issue | 5 |
| container_start_page | 621 |
| container_title | Journal of antimicrobial chemotherapy |
| container_volume | 16 |
| creator | Ruhnek-Forsbeck, Margit Sandström, Eric Andersoon, Beril Eriksson, Gunnel Hersle, Kjell Lövhagen, Gun-Britt Mobacken, Håkan Hillström, Lars Svensson, Louise |
| description | A total of 113 patients with recurrent genital herpes were enrolled in a multicentre cross-over study. Two consecutive recurrences were treated with either oral acyclovir 200 mg or matching placebo five times daily for five days. Acyclovir significantly reduced the time to crusting and healing and the duration of new lesions and symptoms. Acyclovir was not found to have any clinically significant effect on the haemato-logical or biochemical parameters measured, or to have caused adverse events and was well tolerated. Early self-initiated treatment may abort a recurrent attack of genital herpes without progression to the ulcerative or crusting stage. |
| doi_str_mv | 10.1093/jac/16.5.621 |
| format | Article |
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Two consecutive recurrences were treated with either oral acyclovir 200 mg or matching placebo five times daily for five days. Acyclovir significantly reduced the time to crusting and healing and the duration of new lesions and symptoms. Acyclovir was not found to have any clinically significant effect on the haemato-logical or biochemical parameters measured, or to have caused adverse events and was well tolerated. Early self-initiated treatment may abort a recurrent attack of genital herpes without progression to the ulcerative or crusting stage.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/16.5.621</identifier><identifier>PMID: 3908435</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Acyclovir - adverse effects ; Acyclovir - therapeutic use ; Adult ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Biological and medical sciences ; Clinical Trials as Topic ; Double-Blind Method ; Female ; Herpes Genitalis - drug therapy ; Herpes Genitalis - microbiology ; herpes simplex virus ; Humans ; Male ; Medical sciences ; Pharmacology. 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Two consecutive recurrences were treated with either oral acyclovir 200 mg or matching placebo five times daily for five days. Acyclovir significantly reduced the time to crusting and healing and the duration of new lesions and symptoms. Acyclovir was not found to have any clinically significant effect on the haemato-logical or biochemical parameters measured, or to have caused adverse events and was well tolerated. Early self-initiated treatment may abort a recurrent attack of genital herpes without progression to the ulcerative or crusting stage.</description><subject>Acyclovir - adverse effects</subject><subject>Acyclovir - therapeutic use</subject><subject>Adult</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Clinical Trials as Topic</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Herpes Genitalis - drug therapy</subject><subject>Herpes Genitalis - microbiology</subject><subject>herpes simplex virus</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Random Allocation</subject><subject>Recurrence</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLAzEUhYMoWh87t8IsxJXTJpPXZClFrdJihQriJmQydzQ6L5Op2n_vaEtXl8P5OHA_hE4JHhKs6Ojd2BERQz4UCdlBA8IEjhOsyC4aYIp5LBmnB-gwhHeMseAi3Uf7VOGUUT5A04UH01VQd1FTRB7s0vu_8Aq160wZvYFvIUTBVW0JP5GrC7Cda-oQfbvuLWp8zxi7smXz5fwx2itMGeBkc4_Q0831YjyJpw-3d-OraWwZTrs4EZBISROjiMhyUkiSG8KZ5UpJa7EEWZgMslTlDFsO_ROMpkwpm2YkTQSnR-hivdv65nMJodOVCxbK0tTQLIMmjLJEYNKDl2vQ-iYED4VuvauMX2mC9Z883cvTRGiue3k9frbZXWYV5Ft4Y6vvzze9CdaUhTe1dWGLpYwL9j8TrzEXOvjZ1sZ_aCGp5Hry_KLv5-PHuVzM9Iz-AkqXhqg</recordid><startdate>198511</startdate><enddate>198511</enddate><creator>Ruhnek-Forsbeck, Margit</creator><creator>Sandström, Eric</creator><creator>Andersoon, Beril</creator><creator>Eriksson, Gunnel</creator><creator>Hersle, Kjell</creator><creator>Lövhagen, Gun-Britt</creator><creator>Mobacken, Håkan</creator><creator>Hillström, Lars</creator><creator>Svensson, Louise</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>198511</creationdate><title>Treatment of recurrent genital herpes simplex infections with oral acyclovir</title><author>Ruhnek-Forsbeck, Margit ; Sandström, Eric ; Andersoon, Beril ; Eriksson, Gunnel ; Hersle, Kjell ; Lövhagen, Gun-Britt ; Mobacken, Håkan ; Hillström, Lars ; Svensson, Louise</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-26e27732a916bd1f71da154c5997cc07e7fabeb89d40c5e030438499c8b182653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Acyclovir - adverse effects</topic><topic>Acyclovir - therapeutic use</topic><topic>Adult</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Clinical Trials as Topic</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Herpes Genitalis - drug therapy</topic><topic>Herpes Genitalis - microbiology</topic><topic>herpes simplex virus</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Random Allocation</topic><topic>Recurrence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruhnek-Forsbeck, Margit</creatorcontrib><creatorcontrib>Sandström, Eric</creatorcontrib><creatorcontrib>Andersoon, Beril</creatorcontrib><creatorcontrib>Eriksson, Gunnel</creatorcontrib><creatorcontrib>Hersle, Kjell</creatorcontrib><creatorcontrib>Lövhagen, Gun-Britt</creatorcontrib><creatorcontrib>Mobacken, Håkan</creatorcontrib><creatorcontrib>Hillström, Lars</creatorcontrib><creatorcontrib>Svensson, Louise</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruhnek-Forsbeck, Margit</au><au>Sandström, Eric</au><au>Andersoon, Beril</au><au>Eriksson, Gunnel</au><au>Hersle, Kjell</au><au>Lövhagen, Gun-Britt</au><au>Mobacken, Håkan</au><au>Hillström, Lars</au><au>Svensson, Louise</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of recurrent genital herpes simplex infections with oral acyclovir</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>1985-11</date><risdate>1985</risdate><volume>16</volume><issue>5</issue><spage>621</spage><epage>628</epage><pages>621-628</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><coden>JACHDX</coden><abstract>A total of 113 patients with recurrent genital herpes were enrolled in a multicentre cross-over study. Two consecutive recurrences were treated with either oral acyclovir 200 mg or matching placebo five times daily for five days. Acyclovir significantly reduced the time to crusting and healing and the duration of new lesions and symptoms. Acyclovir was not found to have any clinically significant effect on the haemato-logical or biochemical parameters measured, or to have caused adverse events and was well tolerated. Early self-initiated treatment may abort a recurrent attack of genital herpes without progression to the ulcerative or crusting stage.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>3908435</pmid><doi>10.1093/jac/16.5.621</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0305-7453 |
| ispartof | Journal of antimicrobial chemotherapy, 1985-11, Vol.16 (5), p.621-628 |
| issn | 0305-7453 1460-2091 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Acyclovir - adverse effects Acyclovir - therapeutic use Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Clinical Trials as Topic Double-Blind Method Female Herpes Genitalis - drug therapy Herpes Genitalis - microbiology herpes simplex virus Humans Male Medical sciences Pharmacology. Drug treatments Random Allocation Recurrence |
| title | Treatment of recurrent genital herpes simplex infections with oral acyclovir |
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