The effects of low-dose irradiation on the active enhancement of tumor allografts
Active immunologic enhancement is believed to be a phenomenon in which a specific antibody, actively produced by the host, interferes with the host's ability to mount a normal cell-mediated immune reaction against the antigen. The authors' previous experiments have shown that CBA mice give...
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| Veröffentlicht in: | Transplantation 1983-08, Vol.36 (2), p.226-228 |
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| container_title | Transplantation |
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| creator | DOUVAS, G. S KINSKY, R. G |
| description | Active immunologic enhancement is believed to be a phenomenon in which a specific antibody, actively produced by the host, interferes with the host's ability to mount a normal cell-mediated immune reaction against the antigen. The authors' previous experiments have shown that CBA mice given i.p. injections of A/J spleen can no longer reject A/J-derived sarcoma I (SaI) tumor allografts. Mice bearing enhanced tumors develop nylon-wool-nonadherent, I-J super(+) suppressor T cells (Ts) capable of transferring tumor allograft enhancement into naive CBA recipients. Sublethal irradiation (300 rads) of the CBA recipients prior to suppressor cell transfer augments of the activity of the suppressor cells. This led the authors to examine the effects of low-dose irradiation on the generation of active enhancement in six-to-twelve-week-old female mice. |
| doi_str_mv | 10.1097/00007890-198308000-00031 |
| format | Article |
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This led the authors to examine the effects of low-dose irradiation on the generation of active enhancement in six-to-twelve-week-old female mice.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Female</subject><subject>Graft Enhancement, Immunologic</subject><subject>Graft Survival - radiation effects</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred A</subject><subject>Mice, Inbred CBA</subject><subject>Neoplasm Transplantation</subject><subject>Sarcoma, Experimental - pathology</subject><subject>Spleen - transplantation</subject><subject>Tissue Extracts - immunology</subject><subject>Transplantability</subject><subject>Tumor cell</subject><subject>Tumors</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kF1PwyAUhonRzDn9CSa9MN6hMCjQS7P4lSwxJvO6oXBwNW2ZwDT-e5mrI5ATOM8L4UGooOSGkkrekjykqgimlWJE5R3Oi9EjNKUl41jks2M0JYRTTBmTp-gsxo-MlEzKCZoIJSuhxBS9rtZQgHNgUiy8Kzr_ja2PULQhaNvq1PqhyDNlTJvUfmV6WOvBQA9D2iXStveh0F3n34N2KZ6jE6e7CBdjnaG3h_vV4gkvXx6fF3dLbBgtE67I3FpqGdUq_8iquWwkWD0nXDcgQQkG1DQCBEhKuGucVhwaQTjRpbOSsxm63t-7Cf5zCzHVfRsNdJ0ewG9jTTnjhAuSQbUHTfAxBnD1JrS9Dj81JfXOZv1vsz7YrP9s5ujl-Ma26cEegqO-3L8a-zoa3bmQxbTxgFUlpyIr_wUef3zt</recordid><startdate>198308</startdate><enddate>198308</enddate><creator>DOUVAS, G. 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| fulltext | fulltext |
| identifier | ISSN: 0041-1337 |
| ispartof | Transplantation, 1983-08, Vol.36 (2), p.226-228 |
| issn | 0041-1337 1534-6080 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Dose-Response Relationship, Radiation Female Graft Enhancement, Immunologic Graft Survival - radiation effects Medical sciences Mice Mice, Inbred A Mice, Inbred CBA Neoplasm Transplantation Sarcoma, Experimental - pathology Spleen - transplantation Tissue Extracts - immunology Transplantability Tumor cell Tumors |
| title | The effects of low-dose irradiation on the active enhancement of tumor allografts |
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