Tissue Kim-1 and Urinary Clusterin as Early Indicators of Cisplatin-Induced Acute Kidney Injury in Rats

The kidney is one of the main targets of drug toxicity, and early detection of renal damage is critical in preclinical drug development. A model of cisplatin-induced nephrotoxicity in male Sprague Dawley rats treated for 1, 3, 5, 7, or 14 days at 1 mg/kg/day was used to monitor the spatial and tempo...

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Veröffentlicht in:	Toxicologic pathology 2012-10, Vol.40 (7), p.1049-1062
Hauptverfasser:	Vinken, Petra, Starckx, Sofie, Barale-Thomas, Erio, Looszova, Adriana, Sonee, Manisha, Goeminne, Nick, Versmissen, Loes, Buyens, Kristel, Lampo, Ann
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - toxicity Biological and medical sciences Biomarkers - metabolism Blood Chemical Analysis Body Weight - drug effects Cisplatin - toxicity Clusterin - urine Disease Models, Animal Hepatitis A Virus Cellular Receptor 1 Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Diseases - chemically induced Kidney Diseases - metabolism Kidney Diseases - pathology Kidney Tubules - drug effects Kidney Tubules - metabolism Kidney Tubules - pathology Kidneys Male Medical sciences Membrane Proteins - metabolism Nephrology. Urinary tract diseases Organ Size - drug effects Osteopontin - urine Rats Rats, Sprague-Dawley Toxicity Tests - methods Toxicology Urinalysis Urinary system involvement in other diseases. Miscellaneous
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