Human adipose tissue-derived mesenchymal stem cells improve cognitive function and physical activity in ageing mice
Brain ageing leads to atrophy and degeneration of the cholinergic nervous system, resulting in profound neurobehavioral and cognitive dysfunction from decreased acetylcholine biosynthesis and reduced secretion of growth and neurotrophic factors. Human adipose tissue‐derived mesenchymal stem cells (A...
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| Veröffentlicht in: | Journal of neuroscience research 2013-05, Vol.91 (5), p.660-670 |
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| creator | Park, Dongsun Yang, Goeun Bae, Dae Kwon Lee, Sun Hee Yang, Yun-Hui Kyung, Jangbeen Kim, Dajeong Choi, Ehn-Kyoung Choi, Kyung-Chul Kim, Seung U. Kang, Sung Keun Ra, Jeong Chan Kim, Yun-Bae |
| description | Brain ageing leads to atrophy and degeneration of the cholinergic nervous system, resulting in profound neurobehavioral and cognitive dysfunction from decreased acetylcholine biosynthesis and reduced secretion of growth and neurotrophic factors. Human adipose tissue‐derived mesenchymal stem cells (ADMSCs) were intravenously (1 × 106 cells) or intracerebroventricularly (4 × 105 cells) transplanted into the brains of 18‐month‐old mice once or four times at 2‐week intervals. Transplantation of ADMSCs improved both locomotor activity and cognitive function in the aged animals, in parallel with recovery of acetylcholine levels in brain tissues. Transplanted cells differentiated into neurons and, in part, into astrocytes and produced choline acetyltransferase proteins. Transplantation of ADMSCs restored microtubule‐associated protein 2 in brain tissue and enhanced Trk B expression and the concentrations of brain‐derived neurotrophic factor and nerve growth factor. These results indicate that human ADMSCs differentiate into neural cells in the brain microenvironment and can restore physical and cognitive functions of aged mice not only by increasing acetylcholine synthesis but also by restoring neuronal integrity that may be mediated by growth/neurotrophic factors. © 2013 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jnr.23182 |
| format | Article |
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Human adipose tissue‐derived mesenchymal stem cells (ADMSCs) were intravenously (1 × 106 cells) or intracerebroventricularly (4 × 105 cells) transplanted into the brains of 18‐month‐old mice once or four times at 2‐week intervals. Transplantation of ADMSCs improved both locomotor activity and cognitive function in the aged animals, in parallel with recovery of acetylcholine levels in brain tissues. Transplanted cells differentiated into neurons and, in part, into astrocytes and produced choline acetyltransferase proteins. Transplantation of ADMSCs restored microtubule‐associated protein 2 in brain tissue and enhanced Trk B expression and the concentrations of brain‐derived neurotrophic factor and nerve growth factor. These results indicate that human ADMSCs differentiate into neural cells in the brain microenvironment and can restore physical and cognitive functions of aged mice not only by increasing acetylcholine synthesis but also by restoring neuronal integrity that may be mediated by growth/neurotrophic factors. © 2013 Wiley Periodicals, Inc.</description><identifier>ISSN: 0360-4012</identifier><identifier>EISSN: 1097-4547</identifier><identifier>DOI: 10.1002/jnr.23182</identifier><identifier>PMID: 23404260</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Acetylcholine - metabolism ; Adipose Tissue - cytology ; ageing ; Aging - physiology ; Animals ; Avoidance Learning - physiology ; Brain - metabolism ; Brain - pathology ; brain-derived neurotrophic factor ; Cell Count ; Cell Differentiation - physiology ; Choline O-Acetyltransferase - metabolism ; Cognition Disorders - etiology ; Cognition Disorders - physiopathology ; Cognition Disorders - surgery ; cognitive function ; Disease Models, Animal ; Gene Expression Regulation - physiology ; human adipose-derived mesenchymal stem cell ; Humans ; Male ; Maze Learning - physiology ; Mesenchymal Stem Cell Transplantation - methods ; Mesenchymal Stromal Cells - physiology ; Mice ; Mice, Inbred ICR ; Motor Activity - physiology ; nerve growth factor ; Nerve Tissue Proteins - metabolism ; physical activity ; Time Factors</subject><ispartof>Journal of neuroscience research, 2013-05, Vol.91 (5), p.660-670</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4592-ecca2eeb3b7f3318e4fb37b646e5f3138eae8e655133cf4d54160fa7de8c8b463</citedby><cites>FETCH-LOGICAL-c4592-ecca2eeb3b7f3318e4fb37b646e5f3138eae8e655133cf4d54160fa7de8c8b463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjnr.23182$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjnr.23182$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23404260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Dongsun</creatorcontrib><creatorcontrib>Yang, Goeun</creatorcontrib><creatorcontrib>Bae, Dae Kwon</creatorcontrib><creatorcontrib>Lee, Sun Hee</creatorcontrib><creatorcontrib>Yang, Yun-Hui</creatorcontrib><creatorcontrib>Kyung, Jangbeen</creatorcontrib><creatorcontrib>Kim, Dajeong</creatorcontrib><creatorcontrib>Choi, Ehn-Kyoung</creatorcontrib><creatorcontrib>Choi, Kyung-Chul</creatorcontrib><creatorcontrib>Kim, Seung U.</creatorcontrib><creatorcontrib>Kang, Sung Keun</creatorcontrib><creatorcontrib>Ra, Jeong Chan</creatorcontrib><creatorcontrib>Kim, Yun-Bae</creatorcontrib><title>Human adipose tissue-derived mesenchymal stem cells improve cognitive function and physical activity in ageing mice</title><title>Journal of neuroscience research</title><addtitle>J. Neurosci. Res</addtitle><description>Brain ageing leads to atrophy and degeneration of the cholinergic nervous system, resulting in profound neurobehavioral and cognitive dysfunction from decreased acetylcholine biosynthesis and reduced secretion of growth and neurotrophic factors. Human adipose tissue‐derived mesenchymal stem cells (ADMSCs) were intravenously (1 × 106 cells) or intracerebroventricularly (4 × 105 cells) transplanted into the brains of 18‐month‐old mice once or four times at 2‐week intervals. Transplantation of ADMSCs improved both locomotor activity and cognitive function in the aged animals, in parallel with recovery of acetylcholine levels in brain tissues. Transplanted cells differentiated into neurons and, in part, into astrocytes and produced choline acetyltransferase proteins. Transplantation of ADMSCs restored microtubule‐associated protein 2 in brain tissue and enhanced Trk B expression and the concentrations of brain‐derived neurotrophic factor and nerve growth factor. These results indicate that human ADMSCs differentiate into neural cells in the brain microenvironment and can restore physical and cognitive functions of aged mice not only by increasing acetylcholine synthesis but also by restoring neuronal integrity that may be mediated by growth/neurotrophic factors. © 2013 Wiley Periodicals, Inc.</description><subject>Acetylcholine - metabolism</subject><subject>Adipose Tissue - cytology</subject><subject>ageing</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Avoidance Learning - physiology</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>brain-derived neurotrophic factor</subject><subject>Cell Count</subject><subject>Cell Differentiation - physiology</subject><subject>Choline O-Acetyltransferase - metabolism</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - physiopathology</subject><subject>Cognition Disorders - surgery</subject><subject>cognitive function</subject><subject>Disease Models, Animal</subject><subject>Gene Expression Regulation - physiology</subject><subject>human adipose-derived mesenchymal stem cell</subject><subject>Humans</subject><subject>Male</subject><subject>Maze Learning - physiology</subject><subject>Mesenchymal Stem Cell Transplantation - methods</subject><subject>Mesenchymal Stromal Cells - physiology</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Motor Activity - physiology</subject><subject>nerve growth factor</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>physical activity</subject><subject>Time Factors</subject><issn>0360-4012</issn><issn>1097-4547</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAURi0EokNhwQsgS2xgkda_sbNEFbQdjQqqQEhsLMe5mXqIk6mdDOTt8XTaLpAQK0v2uUf-7ofQa0pOKCHsdNPHE8apZk_QgpJKFUIK9RQtCC9JIQhlR-hFShtCSFVJ_hwdMS6IYCVZoHQxBdtj2_jtkACPPqUJigai30GDAyTo3c0cbIfTCAE76LqEfdjGYQfYDevej5nE7dS70Q9Z1Dd4ezMn7_KIzXc7P87Y54c1-H6Ng3fwEj1rbZfg1f15jL59-vj17KJYfT6_PPuwKpyQFSvAOcsAal6rlud0INqaq7oUJciWU67BgoZSSsq5a0UjBS1Ja1UD2ulalPwYvTt4829vJ0ijCT7tE9gehikZKvIaspmy_6M8uyXnmmb07V_oZphin4PsKSUqzWWVqfcHysUhpQit2UYfbJwNJWZfmsmlmbvSMvvm3jjVAZpH8qGlDJwegF--g_nfJrO8un5QFocJn2v7_Thh409TKq6k-X51bvTq-sdS6aX5wv8Ad6CxCQ</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>Park, Dongsun</creator><creator>Yang, Goeun</creator><creator>Bae, Dae Kwon</creator><creator>Lee, Sun Hee</creator><creator>Yang, Yun-Hui</creator><creator>Kyung, Jangbeen</creator><creator>Kim, Dajeong</creator><creator>Choi, Ehn-Kyoung</creator><creator>Choi, Kyung-Chul</creator><creator>Kim, Seung U.</creator><creator>Kang, Sung Keun</creator><creator>Ra, Jeong Chan</creator><creator>Kim, Yun-Bae</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201305</creationdate><title>Human adipose tissue-derived mesenchymal stem cells improve cognitive function and physical activity in ageing mice</title><author>Park, Dongsun ; Yang, Goeun ; Bae, Dae Kwon ; Lee, Sun Hee ; Yang, Yun-Hui ; Kyung, Jangbeen ; Kim, Dajeong ; Choi, Ehn-Kyoung ; Choi, Kyung-Chul ; Kim, Seung U. ; Kang, Sung Keun ; Ra, Jeong Chan ; Kim, Yun-Bae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4592-ecca2eeb3b7f3318e4fb37b646e5f3138eae8e655133cf4d54160fa7de8c8b463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acetylcholine - metabolism</topic><topic>Adipose Tissue - cytology</topic><topic>ageing</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Avoidance Learning - physiology</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>brain-derived neurotrophic factor</topic><topic>Cell Count</topic><topic>Cell Differentiation - physiology</topic><topic>Choline O-Acetyltransferase - metabolism</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - physiopathology</topic><topic>Cognition Disorders - surgery</topic><topic>cognitive function</topic><topic>Disease Models, Animal</topic><topic>Gene Expression Regulation - physiology</topic><topic>human adipose-derived mesenchymal stem cell</topic><topic>Humans</topic><topic>Male</topic><topic>Maze Learning - physiology</topic><topic>Mesenchymal Stem Cell Transplantation - methods</topic><topic>Mesenchymal Stromal Cells - physiology</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Motor Activity - physiology</topic><topic>nerve growth factor</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>physical activity</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Dongsun</creatorcontrib><creatorcontrib>Yang, Goeun</creatorcontrib><creatorcontrib>Bae, Dae Kwon</creatorcontrib><creatorcontrib>Lee, Sun Hee</creatorcontrib><creatorcontrib>Yang, Yun-Hui</creatorcontrib><creatorcontrib>Kyung, Jangbeen</creatorcontrib><creatorcontrib>Kim, Dajeong</creatorcontrib><creatorcontrib>Choi, Ehn-Kyoung</creatorcontrib><creatorcontrib>Choi, Kyung-Chul</creatorcontrib><creatorcontrib>Kim, Seung U.</creatorcontrib><creatorcontrib>Kang, Sung Keun</creatorcontrib><creatorcontrib>Ra, Jeong Chan</creatorcontrib><creatorcontrib>Kim, Yun-Bae</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Dongsun</au><au>Yang, Goeun</au><au>Bae, Dae Kwon</au><au>Lee, Sun Hee</au><au>Yang, Yun-Hui</au><au>Kyung, Jangbeen</au><au>Kim, Dajeong</au><au>Choi, Ehn-Kyoung</au><au>Choi, Kyung-Chul</au><au>Kim, Seung U.</au><au>Kang, Sung Keun</au><au>Ra, Jeong Chan</au><au>Kim, Yun-Bae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human adipose tissue-derived mesenchymal stem cells improve cognitive function and physical activity in ageing mice</atitle><jtitle>Journal of neuroscience research</jtitle><addtitle>J. Neurosci. Res</addtitle><date>2013-05</date><risdate>2013</risdate><volume>91</volume><issue>5</issue><spage>660</spage><epage>670</epage><pages>660-670</pages><issn>0360-4012</issn><eissn>1097-4547</eissn><abstract>Brain ageing leads to atrophy and degeneration of the cholinergic nervous system, resulting in profound neurobehavioral and cognitive dysfunction from decreased acetylcholine biosynthesis and reduced secretion of growth and neurotrophic factors. Human adipose tissue‐derived mesenchymal stem cells (ADMSCs) were intravenously (1 × 106 cells) or intracerebroventricularly (4 × 105 cells) transplanted into the brains of 18‐month‐old mice once or four times at 2‐week intervals. Transplantation of ADMSCs improved both locomotor activity and cognitive function in the aged animals, in parallel with recovery of acetylcholine levels in brain tissues. Transplanted cells differentiated into neurons and, in part, into astrocytes and produced choline acetyltransferase proteins. Transplantation of ADMSCs restored microtubule‐associated protein 2 in brain tissue and enhanced Trk B expression and the concentrations of brain‐derived neurotrophic factor and nerve growth factor. These results indicate that human ADMSCs differentiate into neural cells in the brain microenvironment and can restore physical and cognitive functions of aged mice not only by increasing acetylcholine synthesis but also by restoring neuronal integrity that may be mediated by growth/neurotrophic factors. © 2013 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>23404260</pmid><doi>10.1002/jnr.23182</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetylcholine - metabolism Adipose Tissue - cytology ageing Aging - physiology Animals Avoidance Learning - physiology Brain - metabolism Brain - pathology brain-derived neurotrophic factor Cell Count Cell Differentiation - physiology Choline O-Acetyltransferase - metabolism Cognition Disorders - etiology Cognition Disorders - physiopathology Cognition Disorders - surgery cognitive function Disease Models, Animal Gene Expression Regulation - physiology human adipose-derived mesenchymal stem cell Humans Male Maze Learning - physiology Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stromal Cells - physiology Mice Mice, Inbred ICR Motor Activity - physiology nerve growth factor Nerve Tissue Proteins - metabolism physical activity Time Factors |
| title | Human adipose tissue-derived mesenchymal stem cells improve cognitive function and physical activity in ageing mice |
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