Dose-dependent alterations in gene expression and testosterone production in fetal rat testis after exposure to di-n-hexyl phthalate

ABSTRACT In utero exposure to the phthalate ester plasticizer di‐n‐hexyl phthalate (DnHP) is known to affect the development of the male reproductive system and induce alterations in androgen‐dependent tissues of male rat offspring. Male reproductive malformations produced by several phthalates have...

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Veröffentlicht in:	Journal of applied toxicology 2013-09, Vol.33 (9), p.1027-1035
Hauptverfasser:	Saillenfait, Anne-Marie, Sabaté, Jean-Philippe, Robert, Alain, Rouiller-Fabre, Virginie, Roudot, Alain-Claude, Moison, Delphine, Denis, Flavien
Format:	Artikel
Sprache:	eng
Schlagworte:	adrenals Animals developmental toxicity di-n-hexyl phthalate Diethylhexyl Phthalate - toxicity Dose-Response Relationship, Drug Down-Regulation Female Fetus - drug effects Fetus - pathology gene expression Gene Expression - drug effects Male male reproductive development Maternal Exposure - adverse effects No-Observed-Adverse-Effect Level Olea phthalates Phthalic Acids - administration & dosage Phthalic Acids - toxicity Plasticizers - toxicity Pregnancy Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - pathology rat Rats Rats, Sprague-Dawley Reproduction - drug effects steroidogenesis testis Testis - drug effects Testis - metabolism testosterone Testosterone - biosynthesis
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