Altered expressions of MMP-2, MMP-9, and TIMP-2 in placentas from women exposed to lead
Experimental studies have shown that prenatal exposure to lead (Pb) produces morphological changes related to extracellular matrix remodelling. To analyse whether the matrix metalloproteinases (MMPs), particularly MMP-2, MMP-9, and the tissue inhibitor of metalloproteinases-2 (TIMP-2), are associate...
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| Veröffentlicht in: | Human & experimental toxicology 2012-07, Vol.31 (7), p.662-670 |
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| creator | González-Puebla, E González-Horta, C Infante-Ramírez, R Sanin, LH Levario-Carrillo, M Sánchez-Ramírez, B |
| description | Experimental studies have shown that prenatal exposure to lead (Pb) produces morphological changes related to extracellular matrix remodelling. To analyse whether the matrix metalloproteinases (MMPs), particularly MMP-2, MMP-9, and the tissue inhibitor of metalloproteinases-2 (TIMP-2), are associated with morphological alterations found in placentas, the expression of these enzymes was evaluated by immunohistochemical and image analyses in placentas of women with histories of environmental exposure to Pb. The median maternal concentration of Pb in blood was 4.68 µg/dL (
x
ˉ
= 5.85 ± 6.48 µg/dL). Significant differences related to the exposure to Pb were not detected in newborn or placenta weight. MMP-2, MMP-9, and TIMP-2 were expressed in the syncytiotrophoblast layer of placental villi. A significant increase in both MMP-2 and MMP-9 was observed in placentas of women with concentrations of Pb in blood ≥4.68 µg/dL (p = 0.01 and 0.03 for MMP-2 and MMP-9, respectively) and decrease in TIMP-2 expression (p = 0.01) resulted in a significant increase in MMP-2/TIMP-2 ratio (p |
| doi_str_mv | 10.1177/0960327111431706 |
| format | Article |
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x
ˉ
= 5.85 ± 6.48 µg/dL). Significant differences related to the exposure to Pb were not detected in newborn or placenta weight. MMP-2, MMP-9, and TIMP-2 were expressed in the syncytiotrophoblast layer of placental villi. A significant increase in both MMP-2 and MMP-9 was observed in placentas of women with concentrations of Pb in blood ≥4.68 µg/dL (p = 0.01 and 0.03 for MMP-2 and MMP-9, respectively) and decrease in TIMP-2 expression (p = 0.01) resulted in a significant increase in MMP-2/TIMP-2 ratio (p < 0.01). Increased expression of MMPs may be induced to aid in repairing placental tissue damaged by the exposure to Pb and that TIMP-2 decreases its expression to permit tissue repair. Increased expression of MMPs may be important to consider as a mechanism for generating placental abnormalities and in the induction of preterm delivery or abortion.</description><identifier>ISSN: 0960-3271</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1177/0960327111431706</identifier><identifier>PMID: 22241630</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Abortion ; Adult ; Biological and medical sciences ; Chemical and industrial products toxicology. Toxic occupational diseases ; Cross-Sectional Studies ; Environmental Pollutants - blood ; Environmental Pollutants - toxicity ; Enzymes ; Female ; Fetal Blood - chemistry ; Gene expression ; Human exposure ; Humans ; Lead ; Lead - blood ; Lead - toxicity ; Maternal Exposure - adverse effects ; Maternal-Fetal Exchange ; Matrix Metalloproteinase 2 - metabolism ; Matrix Metalloproteinase 9 - metabolism ; Medical sciences ; Metals and various inorganic compounds ; Mexico ; Occupational Exposure - adverse effects ; Placenta - metabolism ; Pregnancy ; Tissue Inhibitor of Metalloproteinase-2 - metabolism ; Toxicity ; Toxicology ; Young Adult</subject><ispartof>Human & experimental toxicology, 2012-07, Vol.31 (7), p.662-670</ispartof><rights>The Author(s) 2012</rights><rights>2014 INIST-CNRS</rights><rights>SAGE Publications © Jul 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-9ec7357aebbf489dd50d8f644892c3b03daf5ef46b2c821dd276c11e9f666e703</citedby><cites>FETCH-LOGICAL-c470t-9ec7357aebbf489dd50d8f644892c3b03daf5ef46b2c821dd276c11e9f666e703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0960327111431706$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0960327111431706$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21945,27830,27901,27902,44921,45309</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/0960327111431706?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26900741$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22241630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>González-Puebla, E</creatorcontrib><creatorcontrib>González-Horta, C</creatorcontrib><creatorcontrib>Infante-Ramírez, R</creatorcontrib><creatorcontrib>Sanin, LH</creatorcontrib><creatorcontrib>Levario-Carrillo, M</creatorcontrib><creatorcontrib>Sánchez-Ramírez, B</creatorcontrib><title>Altered expressions of MMP-2, MMP-9, and TIMP-2 in placentas from women exposed to lead</title><title>Human & experimental toxicology</title><addtitle>Hum Exp Toxicol</addtitle><description>Experimental studies have shown that prenatal exposure to lead (Pb) produces morphological changes related to extracellular matrix remodelling. To analyse whether the matrix metalloproteinases (MMPs), particularly MMP-2, MMP-9, and the tissue inhibitor of metalloproteinases-2 (TIMP-2), are associated with morphological alterations found in placentas, the expression of these enzymes was evaluated by immunohistochemical and image analyses in placentas of women with histories of environmental exposure to Pb. The median maternal concentration of Pb in blood was 4.68 µg/dL (
x
ˉ
= 5.85 ± 6.48 µg/dL). Significant differences related to the exposure to Pb were not detected in newborn or placenta weight. MMP-2, MMP-9, and TIMP-2 were expressed in the syncytiotrophoblast layer of placental villi. A significant increase in both MMP-2 and MMP-9 was observed in placentas of women with concentrations of Pb in blood ≥4.68 µg/dL (p = 0.01 and 0.03 for MMP-2 and MMP-9, respectively) and decrease in TIMP-2 expression (p = 0.01) resulted in a significant increase in MMP-2/TIMP-2 ratio (p < 0.01). Increased expression of MMPs may be induced to aid in repairing placental tissue damaged by the exposure to Pb and that TIMP-2 decreases its expression to permit tissue repair. Increased expression of MMPs may be important to consider as a mechanism for generating placental abnormalities and in the induction of preterm delivery or abortion.</description><subject>Abortion</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Cross-Sectional Studies</subject><subject>Environmental Pollutants - blood</subject><subject>Environmental Pollutants - toxicity</subject><subject>Enzymes</subject><subject>Female</subject><subject>Fetal Blood - chemistry</subject><subject>Gene expression</subject><subject>Human exposure</subject><subject>Humans</subject><subject>Lead</subject><subject>Lead - blood</subject><subject>Lead - toxicity</subject><subject>Maternal Exposure - adverse effects</subject><subject>Maternal-Fetal Exchange</subject><subject>Matrix Metalloproteinase 2 - metabolism</subject><subject>Matrix Metalloproteinase 9 - metabolism</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Mexico</subject><subject>Occupational Exposure - adverse effects</subject><subject>Placenta - metabolism</subject><subject>Pregnancy</subject><subject>Tissue Inhibitor of Metalloproteinase-2 - metabolism</subject><subject>Toxicity</subject><subject>Toxicology</subject><subject>Young Adult</subject><issn>0960-3271</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc1LHTEUxUOx1FftvqsSEMGFU28-JnlZitRWUOzC0uWQSW7KyMzkmcyj9b9vxveqRRBXN-T-zrnJPYR8ZPCZMa1PwCgQXDPGpGAa1BuyYFLrCgyIHbKY29Xc3yXvc74FAGVq9o7scs4lUwIW5OdpP2FCT_HPKmHOXRwzjYFeXX2v-PFDMcfUjp7eXMxXtBvpqrcOx8lmGlIc6O844DjrYy4-U6Q9Wr9P3gbbZ_ywrXvkx_mXm7Nv1eX114uz08vKSQ1TZdBpUWuLbRvk0nhfg18GJcuZO9GC8DbUGKRquVty5j3XyjGGJiilUIPYI0cb31WKd2vMUzN02WHf2xHjOjdlMRIEyLp-HQWuQTIwM3rwDL2N6zSWjzxQtVyWTRYKNpRLMeeEoVmlbrDpvkDNnE_zPJ8i-bQ1XrcD-kfBv0AKcLgFbHa2D8mOrstPnDIAWrLCVRsu21_4_-teGPwXx06f0g</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>González-Puebla, E</creator><creator>González-Horta, C</creator><creator>Infante-Ramírez, R</creator><creator>Sanin, LH</creator><creator>Levario-Carrillo, M</creator><creator>Sánchez-Ramírez, B</creator><general>SAGE Publications</general><general>Sage Publications</general><general>Sage Publications Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7ST</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>Altered expressions of MMP-2, MMP-9, and TIMP-2 in placentas from women exposed to lead</title><author>González-Puebla, E ; González-Horta, C ; Infante-Ramírez, R ; Sanin, LH ; Levario-Carrillo, M ; Sánchez-Ramírez, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-9ec7357aebbf489dd50d8f644892c3b03daf5ef46b2c821dd276c11e9f666e703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Abortion</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Cross-Sectional Studies</topic><topic>Environmental Pollutants - blood</topic><topic>Environmental Pollutants - toxicity</topic><topic>Enzymes</topic><topic>Female</topic><topic>Fetal Blood - chemistry</topic><topic>Gene expression</topic><topic>Human exposure</topic><topic>Humans</topic><topic>Lead</topic><topic>Lead - blood</topic><topic>Lead - toxicity</topic><topic>Maternal Exposure - adverse effects</topic><topic>Maternal-Fetal Exchange</topic><topic>Matrix Metalloproteinase 2 - metabolism</topic><topic>Matrix Metalloproteinase 9 - metabolism</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Mexico</topic><topic>Occupational Exposure - adverse effects</topic><topic>Placenta - metabolism</topic><topic>Pregnancy</topic><topic>Tissue Inhibitor of Metalloproteinase-2 - metabolism</topic><topic>Toxicity</topic><topic>Toxicology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>González-Puebla, E</creatorcontrib><creatorcontrib>González-Horta, C</creatorcontrib><creatorcontrib>Infante-Ramírez, R</creatorcontrib><creatorcontrib>Sanin, LH</creatorcontrib><creatorcontrib>Levario-Carrillo, M</creatorcontrib><creatorcontrib>Sánchez-Ramírez, B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>González-Puebla, E</au><au>González-Horta, C</au><au>Infante-Ramírez, R</au><au>Sanin, LH</au><au>Levario-Carrillo, M</au><au>Sánchez-Ramírez, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered expressions of MMP-2, MMP-9, and TIMP-2 in placentas from women exposed to lead</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>31</volume><issue>7</issue><spage>662</spage><epage>670</epage><pages>662-670</pages><issn>0960-3271</issn><eissn>1477-0903</eissn><abstract>Experimental studies have shown that prenatal exposure to lead (Pb) produces morphological changes related to extracellular matrix remodelling. To analyse whether the matrix metalloproteinases (MMPs), particularly MMP-2, MMP-9, and the tissue inhibitor of metalloproteinases-2 (TIMP-2), are associated with morphological alterations found in placentas, the expression of these enzymes was evaluated by immunohistochemical and image analyses in placentas of women with histories of environmental exposure to Pb. The median maternal concentration of Pb in blood was 4.68 µg/dL (
x
ˉ
= 5.85 ± 6.48 µg/dL). Significant differences related to the exposure to Pb were not detected in newborn or placenta weight. MMP-2, MMP-9, and TIMP-2 were expressed in the syncytiotrophoblast layer of placental villi. A significant increase in both MMP-2 and MMP-9 was observed in placentas of women with concentrations of Pb in blood ≥4.68 µg/dL (p = 0.01 and 0.03 for MMP-2 and MMP-9, respectively) and decrease in TIMP-2 expression (p = 0.01) resulted in a significant increase in MMP-2/TIMP-2 ratio (p < 0.01). Increased expression of MMPs may be induced to aid in repairing placental tissue damaged by the exposure to Pb and that TIMP-2 decreases its expression to permit tissue repair. Increased expression of MMPs may be important to consider as a mechanism for generating placental abnormalities and in the induction of preterm delivery or abortion.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>22241630</pmid><doi>10.1177/0960327111431706</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abortion Adult Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Cross-Sectional Studies Environmental Pollutants - blood Environmental Pollutants - toxicity Enzymes Female Fetal Blood - chemistry Gene expression Human exposure Humans Lead Lead - blood Lead - toxicity Maternal Exposure - adverse effects Maternal-Fetal Exchange Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Medical sciences Metals and various inorganic compounds Mexico Occupational Exposure - adverse effects Placenta - metabolism Pregnancy Tissue Inhibitor of Metalloproteinase-2 - metabolism Toxicity Toxicology Young Adult |
| title | Altered expressions of MMP-2, MMP-9, and TIMP-2 in placentas from women exposed to lead |
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