Family-based genome-wide copy number scan identifies five new genes of dyslexia involved in dendritic spinal plasticity

Genome-wide screening for copy number variations (CNVs) in ten Indian dyslexic families revealed the presence of five de novo CNVs in regions harboring GABARAP, NEGR1, ACCN1, DCDC5, and one in already known candidate gene CNTNAP2. These genes are located on regions of chromosomes 17p13.1, 1p31.1, 17...

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Veröffentlicht in:	Journal of human genetics 2013-08, Vol.58 (8), p.539-547
Hauptverfasser:	Veerappa, Avinash M, Saldanha, Marita, Padakannaya, Prakash, Ramachandra, Nallur B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Axon guidance Cell adhesion Cell adhesion & migration Child Chromosome Breakage Cognition Copy number Dendritic plasticity Dendritic Spines - metabolism DNA Copy Number Variations - genetics Dyslexia Dyslexia - genetics Family Female GABARAP protein Gene Ontology Genetic Predisposition to Disease Genome-Wide Association Study Genomes Humans Male Neuronal Plasticity - genetics Neuropsychological Tests Phenotype Polymorphism, Genetic Protein Interaction Maps - genetics Reproducibility of Results Signal Transduction - genetics Spinal plasticity Synaptic transmission Young Adult
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