Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients
Abstract Background and objective Multiple sclerosis (MS) is a chronic neurological disease characterized by central nervous system (CNS) inflammation and demyelination of nerve axons. The aim of this study was to investigate a possible association between the methylenetetrahydrofolate reductase (MT...
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| Veröffentlicht in: | Clinical neurology and neurosurgery 2013-09, Vol.115 (9), p.1657-1660 |
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| creator | Fekih Mrissa, Najiba Mrad, Meriem Klai, Sarra Zaouali, Jamel Sayeh, Aycha Mazigh, Chakib Nsiri, Brahim Machgoul, Salem Gritli, Nasreddine Mrissa, Ridha |
| description | Abstract Background and objective Multiple sclerosis (MS) is a chronic neurological disease characterized by central nervous system (CNS) inflammation and demyelination of nerve axons. The aim of this study was to investigate a possible association between the methylenetetrahydrofolate reductase (MTHFR) gene and multiple sclerosis in Tunisian patients. Patients and methods The genotyping of two missense variants of the methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C was performed in 80 multiple sclerosis patients and 200 healthy controls. Results No significant differences were found in the frequency of the MTHFR C677T polymorphism between MS patients and healthy controls. However, the genotype prevalence of the missense variant MTHFR A1298C was significantly different between patients and controls (A/C: 55% versus 7%, p < 10−3 ; C/C: 13.75% versus 0%, p < 10−3 , respectively). Conclusion Although our preliminary findings suggest no association between the MTHFR C677T variants and MS, there is evidence to suggest a significant association between the MTHFR A1298C polymorphisms and MS. |
| doi_str_mv | 10.1016/j.clineuro.2013.02.025 |
| format | Article |
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The aim of this study was to investigate a possible association between the methylenetetrahydrofolate reductase (MTHFR) gene and multiple sclerosis in Tunisian patients. Patients and methods The genotyping of two missense variants of the methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C was performed in 80 multiple sclerosis patients and 200 healthy controls. Results No significant differences were found in the frequency of the MTHFR C677T polymorphism between MS patients and healthy controls. However, the genotype prevalence of the missense variant MTHFR A1298C was significantly different between patients and controls (A/C: 55% versus 7%, p < 10−3 ; C/C: 13.75% versus 0%, p < 10−3 , respectively). Conclusion Although our preliminary findings suggest no association between the MTHFR C677T variants and MS, there is evidence to suggest a significant association between the MTHFR A1298C polymorphisms and MS.</description><identifier>ISSN: 0303-8467</identifier><identifier>EISSN: 1872-6968</identifier><identifier>DOI: 10.1016/j.clineuro.2013.02.025</identifier><identifier>PMID: 23523621</identifier><identifier>CODEN: CNNSBV</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Autoimmune diseases ; Confidence intervals ; Data Interpretation, Statistical ; Disease ; DNA methylation ; Enzymes ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Homocysteine ; Homocysteine - blood ; Humans ; Male ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; Methylenetetrahydrofolate reductase polymorphism ; Middle Aged ; Multiple sclerosis ; Multiple Sclerosis - epidemiology ; Multiple Sclerosis - genetics ; Mutation ; Mutation, Missense ; Neurology ; Neurosurgery ; NMR ; Nuclear magnetic resonance ; Patients ; Polymerase Chain Reaction ; Polymorphism, Genetic - genetics ; Tunisia - epidemiology ; Vitamin B ; Young Adult</subject><ispartof>Clinical neurology and neurosurgery, 2013-09, Vol.115 (9), p.1657-1660</ispartof><rights>Elsevier B.V.</rights><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Limited 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-4aad01520e2392ba34266b739f91ba9b0da382203080515cff8f9efc09c0feb83</citedby><cites>FETCH-LOGICAL-c484t-4aad01520e2392ba34266b739f91ba9b0da382203080515cff8f9efc09c0feb83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1428641386?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23523621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fekih Mrissa, Najiba</creatorcontrib><creatorcontrib>Mrad, Meriem</creatorcontrib><creatorcontrib>Klai, Sarra</creatorcontrib><creatorcontrib>Zaouali, Jamel</creatorcontrib><creatorcontrib>Sayeh, Aycha</creatorcontrib><creatorcontrib>Mazigh, Chakib</creatorcontrib><creatorcontrib>Nsiri, Brahim</creatorcontrib><creatorcontrib>Machgoul, Salem</creatorcontrib><creatorcontrib>Gritli, Nasreddine</creatorcontrib><creatorcontrib>Mrissa, Ridha</creatorcontrib><title>Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients</title><title>Clinical neurology and neurosurgery</title><addtitle>Clin Neurol Neurosurg</addtitle><description>Abstract Background and objective Multiple sclerosis (MS) is a chronic neurological disease characterized by central nervous system (CNS) inflammation and demyelination of nerve axons. The aim of this study was to investigate a possible association between the methylenetetrahydrofolate reductase (MTHFR) gene and multiple sclerosis in Tunisian patients. Patients and methods The genotyping of two missense variants of the methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C was performed in 80 multiple sclerosis patients and 200 healthy controls. Results No significant differences were found in the frequency of the MTHFR C677T polymorphism between MS patients and healthy controls. However, the genotype prevalence of the missense variant MTHFR A1298C was significantly different between patients and controls (A/C: 55% versus 7%, p < 10−3 ; C/C: 13.75% versus 0%, p < 10−3 , respectively). Conclusion Although our preliminary findings suggest no association between the MTHFR C677T variants and MS, there is evidence to suggest a significant association between the MTHFR A1298C polymorphisms and MS.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Autoimmune diseases</subject><subject>Confidence intervals</subject><subject>Data Interpretation, Statistical</subject><subject>Disease</subject><subject>DNA methylation</subject><subject>Enzymes</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Homocysteine</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Male</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>Methylenetetrahydrofolate reductase polymorphism</subject><subject>Middle Aged</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - epidemiology</subject><subject>Multiple Sclerosis - genetics</subject><subject>Mutation</subject><subject>Mutation, Missense</subject><subject>Neurology</subject><subject>Neurosurgery</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Tunisia - epidemiology</subject><subject>Vitamin B</subject><subject>Young Adult</subject><issn>0303-8467</issn><issn>1872-6968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk2LFDEQhhtR3HH1LywBL156zEd3On0Rh8EvWPDgeA7pdIXJmE7aJK3M3R9umtlV2ItCQV2eeot636qqG4K3BBP--rTVznpYYthSTNgW01Lto2pDREdr3nPxuNpghlktGt5dVc9SOmGMGePiaXVFWUsZp2RT_dqlFLRV2QaPgkET5OPZgYcMOarjeYzBBKcyoAjjorNKgHaE9mKP5uDOU4jz0aYJDUtGPuRVYs-77oB-2nxE0-KynR2gpB3EkGxC1qPD4m2yyqO5rAWf0_PqiVEuwYu7fl19ff_usP9Y337-8Gm_u611I5pcN0qNmLQUA2U9HRRrKOdDx3rTk0H1Ax4VE5SWqwVuSauNEaYHo3GvsYFBsOvq1UV3juH7AinLySYNzikPYUmSNKzBtGtw_x8o7TkrRqzoywfoKSzRl0NWSvCGMMELxS-ULj6kCEbO0U4qniXBco1UnuR9pHKNVGJaqi2DN3fyyzDB-GfsPsMCvL0AUKz7YSHKpIutGkYbQWc5BvvvHW8eSKyY1cp9gzOkv_fIVAbkl_Wx1r8irPyUEB37DYtNy00</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Fekih Mrissa, Najiba</creator><creator>Mrad, Meriem</creator><creator>Klai, Sarra</creator><creator>Zaouali, Jamel</creator><creator>Sayeh, Aycha</creator><creator>Mazigh, Chakib</creator><creator>Nsiri, Brahim</creator><creator>Machgoul, Salem</creator><creator>Gritli, Nasreddine</creator><creator>Mrissa, Ridha</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20130901</creationdate><title>Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients</title><author>Fekih Mrissa, Najiba ; Mrad, Meriem ; Klai, Sarra ; Zaouali, Jamel ; Sayeh, Aycha ; Mazigh, Chakib ; Nsiri, Brahim ; Machgoul, Salem ; Gritli, Nasreddine ; Mrissa, Ridha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-4aad01520e2392ba34266b739f91ba9b0da382203080515cff8f9efc09c0feb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Autoimmune diseases</topic><topic>Confidence intervals</topic><topic>Data Interpretation, Statistical</topic><topic>Disease</topic><topic>DNA methylation</topic><topic>Enzymes</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Homocysteine</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Male</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>Methylenetetrahydrofolate reductase polymorphism</topic><topic>Middle Aged</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - epidemiology</topic><topic>Multiple Sclerosis - genetics</topic><topic>Mutation</topic><topic>Mutation, Missense</topic><topic>Neurology</topic><topic>Neurosurgery</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Patients</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Tunisia - epidemiology</topic><topic>Vitamin B</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fekih Mrissa, Najiba</creatorcontrib><creatorcontrib>Mrad, Meriem</creatorcontrib><creatorcontrib>Klai, Sarra</creatorcontrib><creatorcontrib>Zaouali, Jamel</creatorcontrib><creatorcontrib>Sayeh, Aycha</creatorcontrib><creatorcontrib>Mazigh, Chakib</creatorcontrib><creatorcontrib>Nsiri, Brahim</creatorcontrib><creatorcontrib>Machgoul, Salem</creatorcontrib><creatorcontrib>Gritli, Nasreddine</creatorcontrib><creatorcontrib>Mrissa, Ridha</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical neurology and neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fekih Mrissa, Najiba</au><au>Mrad, Meriem</au><au>Klai, Sarra</au><au>Zaouali, Jamel</au><au>Sayeh, Aycha</au><au>Mazigh, Chakib</au><au>Nsiri, Brahim</au><au>Machgoul, Salem</au><au>Gritli, Nasreddine</au><au>Mrissa, Ridha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients</atitle><jtitle>Clinical neurology and neurosurgery</jtitle><addtitle>Clin Neurol Neurosurg</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>115</volume><issue>9</issue><spage>1657</spage><epage>1660</epage><pages>1657-1660</pages><issn>0303-8467</issn><eissn>1872-6968</eissn><coden>CNNSBV</coden><abstract>Abstract Background and objective Multiple sclerosis (MS) is a chronic neurological disease characterized by central nervous system (CNS) inflammation and demyelination of nerve axons. The aim of this study was to investigate a possible association between the methylenetetrahydrofolate reductase (MTHFR) gene and multiple sclerosis in Tunisian patients. Patients and methods The genotyping of two missense variants of the methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C was performed in 80 multiple sclerosis patients and 200 healthy controls. Results No significant differences were found in the frequency of the MTHFR C677T polymorphism between MS patients and healthy controls. However, the genotype prevalence of the missense variant MTHFR A1298C was significantly different between patients and controls (A/C: 55% versus 7%, p < 10−3 ; C/C: 13.75% versus 0%, p < 10−3 , respectively). Conclusion Although our preliminary findings suggest no association between the MTHFR C677T variants and MS, there is evidence to suggest a significant association between the MTHFR A1298C polymorphisms and MS.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>23523621</pmid><doi>10.1016/j.clineuro.2013.02.025</doi><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Adult Autoimmune diseases Confidence intervals Data Interpretation, Statistical Disease DNA methylation Enzymes Female Gene Frequency Genetic Predisposition to Disease Genotype Homocysteine Homocysteine - blood Humans Male Methylenetetrahydrofolate Reductase (NADPH2) - genetics Methylenetetrahydrofolate reductase polymorphism Middle Aged Multiple sclerosis Multiple Sclerosis - epidemiology Multiple Sclerosis - genetics Mutation Mutation, Missense Neurology Neurosurgery NMR Nuclear magnetic resonance Patients Polymerase Chain Reaction Polymorphism, Genetic - genetics Tunisia - epidemiology Vitamin B Young Adult |
| title | Association of methylenetetrahydrofolate reductase A1298C polymorphism but not of C677T with multiple sclerosis in Tunisian patients |
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