Individual Hematopoietic Stem Cells in Human Bone Marrow of Patients with Aplastic Anemia or Myelodysplastic Syndrome Stably Give Rise to Limited Cell Lineages

Mutation of the phosphatidylinositol N‐acetylglucosaminyltransferase subunit A (PIG‐A) gene in hematopoietic stem cells (HSCs) results in the loss of glycosylphosphatidylinositol‐anchored proteins (GPI‐APs) on HSCs, but minimally affects their development, and thus can be used as a clonal maker of H...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2013-03, Vol.31 (3), p.536-546
Hauptverfasser:	Katagiri, Takamasa, Kawamoto, Hiroshi, Nakakuki, Takashi, Ishiyama, Ken, Okada‐Hatakeyama, Mariko, Ohtake, Shigeki, Seiki, Yu, Hosokawa, Kohei, Nakao, Shinji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Anemia Anemia, Aplastic - genetics Anemia, Aplastic - metabolism Anemia, Aplastic - pathology Aplastic anemia Bone marrow Bone Marrow Cells - metabolism Bone Marrow Cells - pathology Case-Control Studies Cell Differentiation - physiology Cell Lineage Child Child, Preschool Cloning Computer simulation Differentiation Experimental models Female Fluorescence‐activated cell sorting Glycosylphosphatidylinositols - metabolism Hematopoietic progenitors Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - pathology Hemopoietic stem cells Humans Infant Male Membrane Proteins - genetics Membrane Proteins - metabolism Middle Aged Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - metabolism Myelodysplastic Syndromes - pathology Stem cells Young Adult
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