p130Cas alters the differentiation potential of mammary luminal progenitors by deregulating c‐Kit activity

It has recently been proposed that defective differentiation of mammary luminal progenitors predisposes to basal‐like breast cancer. However, the molecular and cellular mechanisms involved are still unclear. Here, we describe that the adaptor protein p130Cas is a crucial regulator of mouse mammary e...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2013-07, Vol.31 (7), p.1422-1433
Hauptverfasser:	Tornillo, Giusy, Elia, Angela Rita, Castellano, Isabella, Spadaro, Michela, Bernabei, Paola, Bisaro, Brigitte, Camacho‐Leal, Maria del Pilar, Pincini, Alessandra, Provero, Paolo, Sapino, Anna, Turco, Emilia, Defilippi, Paola, Cabodi, Sara
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basal‐like breast cancer Breast cancer Cell Differentiation - physiology Cell Growth Processes - physiology Cells, Cultured Crk-Associated Substrate Protein - biosynthesis Crk-Associated Substrate Protein - genetics Crk-Associated Substrate Protein - metabolism c‐Kit Differentiation Female Humans Immunohistochemistry Mammary Glands, Animal - cytology Mammary Glands, Animal - metabolism Mammary luminal progenitor Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Mice Mice, Transgenic p130Cas Pregnancy Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-kit - metabolism Rodents Signal Transduction Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!