Imaging P-glycoprotein function in rats using [ super(11)C]-N-desmethyl-loper amide

Objective: One mechanism that may be responsible for drug resistance in epilepsy is the upregulation of P-glycoprotein (P-gp), a drug efflux pump, at the epileptogenic focus. In this study, we sought to evaluate the potential of a recently developed P-gp PET radiotracer, [ super(11)C]N-desmethyl-lop...

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Veröffentlicht in:	Annals of nuclear medicine 2013-08, Vol.27 (7), p.618-624
Hauptverfasser:	Farwell, Michael D, Chong, Derek J, Iida, Yasuhiko, Bae, Sung A, Easwaramoorthy, Balu, Ichise, Masanori
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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