Fetal obstructive uropathy complicated by urinary ascites: outcome and prognostic value of fetal serum [beta]-2-microglobulin

Fetal obstructive uropathy complicated by urinary ascites: outcome and prognostic value of fetal serum [beta]-2-microglobulin

Objectives To determine whether the prognostic value of fetal serum [beta]-2-microglobulin is altered and whether the occurrence of fetal urinary ascites prevents kidney damage in cases of fetal obstructive uropathy with urinary ascites. Methods This was a retrospective study of cases of fetal bilat...

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Veröffentlicht in:Ultrasound in obstetrics & gynecology 2013-02, Vol.41 (2), p.185-189
Hauptverfasser: Spaggiari, E, Dreux, S, Czerkiewicz, I, Favre, R, Schmitz, T, Guimiot, F, Laurichesse Delmas, H, Verspyck, E, Oury, J.-F, Ville, Y, Muller, F
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container_issue 2
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container_title Ultrasound in obstetrics & gynecology
container_volume 41
creator Spaggiari, E
Dreux, S
Czerkiewicz, I
Favre, R
Schmitz, T
Guimiot, F
Laurichesse Delmas, H
Verspyck, E
Oury, J.-F
Ville, Y
Muller, F
description Objectives To determine whether the prognostic value of fetal serum [beta]-2-microglobulin is altered and whether the occurrence of fetal urinary ascites prevents kidney damage in cases of fetal obstructive uropathy with urinary ascites. Methods This was a retrospective study of cases of fetal bilateral obstructive uropathy that occurred between 2006 and 2010, for which both fetal serum and ascites samples were sent to our laboratory for analysis. [beta]-2-microglobulin was assayed in both fetal serum and the corresponding ascites. Renal outcome was analyzed. Histological features of the kidney in cases of termination of pregnancy and renal function of liveborn infants were recorded. Results Fourteen cases with analysis of fetal serum and fetal ascites in a context of urinary obstruction were included. Renal outcome was unfavorable in eight cases (57%) and favorable in six (43%). When fetal serum [beta]-2-microglobulin was
doi_str_mv 10.1002/uog.12328
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Methods This was a retrospective study of cases of fetal bilateral obstructive uropathy that occurred between 2006 and 2010, for which both fetal serum and ascites samples were sent to our laboratory for analysis. [beta]-2-microglobulin was assayed in both fetal serum and the corresponding ascites. Renal outcome was analyzed. Histological features of the kidney in cases of termination of pregnancy and renal function of liveborn infants were recorded. Results Fourteen cases with analysis of fetal serum and fetal ascites in a context of urinary obstruction were included. Renal outcome was unfavorable in eight cases (57%) and favorable in six (43%). When fetal serum [beta]-2-microglobulin was&lt;5mg/L, renal outcome was favorable in all cases (4/4). When fetal serum [beta]-2-microglobulin was ≥5mg/L, 8/10 cases (80%) had an unfavorable renal outcome (sensitivity, 100%; specificity, 66%). Conclusion Fetal serum [beta]-2-microglobulin reliably predicts postnatal renal outcome in obstructive uropathy complicated by urinary ascites. Moreover, urine extravasation does not seem to protect fetal renal function. [PUBLICATION ABSTRACT]</description><identifier>ISSN: 0960-7692</identifier><identifier>EISSN: 1469-0705</identifier><identifier>DOI: 10.1002/uog.12328</identifier><identifier>CODEN: UOGYFJ</identifier><language>eng</language><publisher>London: Wiley Subscription Services, Inc</publisher><ispartof>Ultrasound in obstetrics &amp; gynecology, 2013-02, Vol.41 (2), p.185-189</ispartof><rights>Copyright © 2013 ISUOG. Published by John Wiley &amp; Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Spaggiari, E</creatorcontrib><creatorcontrib>Dreux, S</creatorcontrib><creatorcontrib>Czerkiewicz, I</creatorcontrib><creatorcontrib>Favre, R</creatorcontrib><creatorcontrib>Schmitz, T</creatorcontrib><creatorcontrib>Guimiot, F</creatorcontrib><creatorcontrib>Laurichesse Delmas, H</creatorcontrib><creatorcontrib>Verspyck, E</creatorcontrib><creatorcontrib>Oury, J.-F</creatorcontrib><creatorcontrib>Ville, Y</creatorcontrib><creatorcontrib>Muller, F</creatorcontrib><title>Fetal obstructive uropathy complicated by urinary ascites: outcome and prognostic value of fetal serum [beta]-2-microglobulin</title><title>Ultrasound in obstetrics &amp; gynecology</title><description>Objectives To determine whether the prognostic value of fetal serum [beta]-2-microglobulin is altered and whether the occurrence of fetal urinary ascites prevents kidney damage in cases of fetal obstructive uropathy with urinary ascites. Methods This was a retrospective study of cases of fetal bilateral obstructive uropathy that occurred between 2006 and 2010, for which both fetal serum and ascites samples were sent to our laboratory for analysis. [beta]-2-microglobulin was assayed in both fetal serum and the corresponding ascites. Renal outcome was analyzed. Histological features of the kidney in cases of termination of pregnancy and renal function of liveborn infants were recorded. Results Fourteen cases with analysis of fetal serum and fetal ascites in a context of urinary obstruction were included. Renal outcome was unfavorable in eight cases (57%) and favorable in six (43%). When fetal serum [beta]-2-microglobulin was&lt;5mg/L, renal outcome was favorable in all cases (4/4). When fetal serum [beta]-2-microglobulin was ≥5mg/L, 8/10 cases (80%) had an unfavorable renal outcome (sensitivity, 100%; specificity, 66%). Conclusion Fetal serum [beta]-2-microglobulin reliably predicts postnatal renal outcome in obstructive uropathy complicated by urinary ascites. Moreover, urine extravasation does not seem to protect fetal renal function. 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Methods This was a retrospective study of cases of fetal bilateral obstructive uropathy that occurred between 2006 and 2010, for which both fetal serum and ascites samples were sent to our laboratory for analysis. [beta]-2-microglobulin was assayed in both fetal serum and the corresponding ascites. Renal outcome was analyzed. Histological features of the kidney in cases of termination of pregnancy and renal function of liveborn infants were recorded. Results Fourteen cases with analysis of fetal serum and fetal ascites in a context of urinary obstruction were included. Renal outcome was unfavorable in eight cases (57%) and favorable in six (43%). When fetal serum [beta]-2-microglobulin was&lt;5mg/L, renal outcome was favorable in all cases (4/4). When fetal serum [beta]-2-microglobulin was ≥5mg/L, 8/10 cases (80%) had an unfavorable renal outcome (sensitivity, 100%; specificity, 66%). Conclusion Fetal serum [beta]-2-microglobulin reliably predicts postnatal renal outcome in obstructive uropathy complicated by urinary ascites. Moreover, urine extravasation does not seem to protect fetal renal function. [PUBLICATION ABSTRACT]</abstract><cop>London</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/uog.12328</doi><tpages>5</tpages></addata></record>
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