Coexpression of Runx1 and Runx3 in mechanoreceptive dorsal root ganglion neurons
Runt‐related transcription factors (Runx) regulate the development of various cells. It has been reported that Runx1 and Runx3 are expressed in distinct subpopulations of primary sensory neurons in the dorsal root ganglion (DRG), and play important roles in the differentiation of nociceptive and pro...
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| Veröffentlicht in: | Developmental neurobiology (Hoboken, N.J.) N.J.), 2013-06, Vol.73 (6), p.469-479 |
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| container_title | Developmental neurobiology (Hoboken, N.J.) |
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| creator | Yoshikawa, Masaaki Murakami, Yuuki Senzaki, Kouji Masuda, Tomoyuki Ozaki, Shigeru Ito, Yoshiaki Shiga, Takashi |
| description | Runt‐related transcription factors (Runx) regulate the development of various cells. It has been reported that Runx1 and Runx3 are expressed in distinct subpopulations of primary sensory neurons in the dorsal root ganglion (DRG), and play important roles in the differentiation of nociceptive and proprioceptive neurons, respectively. In the present study, we examined the developmental changes of the expression of Runx1 and Runx3 in the mouse DRG during embryonic and postnatal stages. We found that the expression of Runx3 preceded that of Runx1, but dramatically decreased before birth, whereas the Runx1 expression was maintained during postnatal periods. These results suggest that roles of Runx1 and Runx3 may change dynamically in the differentiation and maturation of DRG neurons. In addition, several DRG neurons expressed both Runx1 and Runx3 throughout embryonic and postnatal stages and many Runx3‐expressing DRG neurons coexpressed Runx1 at postnatal day 28. Double and triple labeling studies suggest that some of the Runx1/Runx3‐double expressing neurons coexpressed TrkB, c‐ret, and TrkC, which have been shown in the mechanoreceptive DRG neurons. These results suggest that Runx1/Runx3‐double expressing neurons may represent mechanoreceptive properties in the DRG.© 2013 Wiley Periodicals, Inc. Develop Neurobiol 73: 469–479, 2013 |
| doi_str_mv | 10.1002/dneu.22073 |
| format | Article |
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It has been reported that Runx1 and Runx3 are expressed in distinct subpopulations of primary sensory neurons in the dorsal root ganglion (DRG), and play important roles in the differentiation of nociceptive and proprioceptive neurons, respectively. In the present study, we examined the developmental changes of the expression of Runx1 and Runx3 in the mouse DRG during embryonic and postnatal stages. We found that the expression of Runx3 preceded that of Runx1, but dramatically decreased before birth, whereas the Runx1 expression was maintained during postnatal periods. These results suggest that roles of Runx1 and Runx3 may change dynamically in the differentiation and maturation of DRG neurons. In addition, several DRG neurons expressed both Runx1 and Runx3 throughout embryonic and postnatal stages and many Runx3‐expressing DRG neurons coexpressed Runx1 at postnatal day 28. Double and triple labeling studies suggest that some of the Runx1/Runx3‐double expressing neurons coexpressed TrkB, c‐ret, and TrkC, which have been shown in the mechanoreceptive DRG neurons. These results suggest that Runx1/Runx3‐double expressing neurons may represent mechanoreceptive properties in the DRG.© 2013 Wiley Periodicals, Inc. Develop Neurobiol 73: 469–479, 2013</description><identifier>ISSN: 1932-8451</identifier><identifier>EISSN: 1932-846X</identifier><identifier>DOI: 10.1002/dneu.22073</identifier><identifier>PMID: 23378040</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animals ; Animals, Newborn ; Core Binding Factor Alpha 2 Subunit - biosynthesis ; Core Binding Factor Alpha 3 Subunit - biosynthesis ; Developmental stages ; DRG ; Female ; Ganglia, Spinal - metabolism ; Gene Expression Regulation ; mechanoreceptor ; Mechanoreceptors - metabolism ; Mice ; Mice, Inbred C57BL ; Neurons - metabolism ; Pregnancy ; Runx1 ; Runx3 ; transcription factor</subject><ispartof>Developmental neurobiology (Hoboken, N.J.), 2013-06, Vol.73 (6), p.469-479</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4923-973c47078e794b4e9ad9021cfea2ef8f6eb8ff7190631887c3261956734882173</citedby><cites>FETCH-LOGICAL-c4923-973c47078e794b4e9ad9021cfea2ef8f6eb8ff7190631887c3261956734882173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fdneu.22073$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fdneu.22073$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,1428,27905,27906,45555,45556,46390,46814</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23378040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoshikawa, Masaaki</creatorcontrib><creatorcontrib>Murakami, Yuuki</creatorcontrib><creatorcontrib>Senzaki, Kouji</creatorcontrib><creatorcontrib>Masuda, Tomoyuki</creatorcontrib><creatorcontrib>Ozaki, Shigeru</creatorcontrib><creatorcontrib>Ito, Yoshiaki</creatorcontrib><creatorcontrib>Shiga, Takashi</creatorcontrib><title>Coexpression of Runx1 and Runx3 in mechanoreceptive dorsal root ganglion neurons</title><title>Developmental neurobiology (Hoboken, N.J.)</title><addtitle>Dev Neurobiol</addtitle><description>Runt‐related transcription factors (Runx) regulate the development of various cells. It has been reported that Runx1 and Runx3 are expressed in distinct subpopulations of primary sensory neurons in the dorsal root ganglion (DRG), and play important roles in the differentiation of nociceptive and proprioceptive neurons, respectively. In the present study, we examined the developmental changes of the expression of Runx1 and Runx3 in the mouse DRG during embryonic and postnatal stages. We found that the expression of Runx3 preceded that of Runx1, but dramatically decreased before birth, whereas the Runx1 expression was maintained during postnatal periods. These results suggest that roles of Runx1 and Runx3 may change dynamically in the differentiation and maturation of DRG neurons. In addition, several DRG neurons expressed both Runx1 and Runx3 throughout embryonic and postnatal stages and many Runx3‐expressing DRG neurons coexpressed Runx1 at postnatal day 28. Double and triple labeling studies suggest that some of the Runx1/Runx3‐double expressing neurons coexpressed TrkB, c‐ret, and TrkC, which have been shown in the mechanoreceptive DRG neurons. These results suggest that Runx1/Runx3‐double expressing neurons may represent mechanoreceptive properties in the DRG.© 2013 Wiley Periodicals, Inc. Develop Neurobiol 73: 469–479, 2013</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Core Binding Factor Alpha 2 Subunit - biosynthesis</subject><subject>Core Binding Factor Alpha 3 Subunit - biosynthesis</subject><subject>Developmental stages</subject><subject>DRG</subject><subject>Female</subject><subject>Ganglia, Spinal - metabolism</subject><subject>Gene Expression Regulation</subject><subject>mechanoreceptor</subject><subject>Mechanoreceptors - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neurons - metabolism</subject><subject>Pregnancy</subject><subject>Runx1</subject><subject>Runx3</subject><subject>transcription factor</subject><issn>1932-8451</issn><issn>1932-846X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1LwzAYB_AgipvTix9ACl5E2Mxbk_Qoc77AUBEH3krWPp0dbVKTVbdvb7vNHTzoKc_h9_x5wh-hU4IHBGN6lRqoB5RiyfZQl0SM9hUXb_u7OSQddOT9HOOQUYEPUYcyJhXmuIuehxaWlQPvc2sCmwUvtVmSQJt0PbEgN0EJybs21kEC1SL_hCC1zusicNYugpk2s6LdbY5w1vhjdJDpwsPJ9u2hye3odXjfHz_dPQyvx_2ER5T1I8kSLrFUICM-5RDpNMKUJBloCpnKBExVlkkSYcGIUjJpLidRKCTjSlEiWQ9dbHIrZz9q8Iu4zH0CRaEN2NrHhDOOaSgI-58yRrASTPGGnv-ic1s703ykUVRKQULRqsuNSpz13kEWVy4vtVvFBMdtJXFbSbyupMFn28h6WkK6oz8dNIBswFdewOqPqPjmcTTZhH4Dl9SUEA</recordid><startdate>201306</startdate><enddate>201306</enddate><creator>Yoshikawa, Masaaki</creator><creator>Murakami, Yuuki</creator><creator>Senzaki, Kouji</creator><creator>Masuda, Tomoyuki</creator><creator>Ozaki, Shigeru</creator><creator>Ito, Yoshiaki</creator><creator>Shiga, Takashi</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201306</creationdate><title>Coexpression of Runx1 and Runx3 in mechanoreceptive dorsal root ganglion neurons</title><author>Yoshikawa, Masaaki ; 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It has been reported that Runx1 and Runx3 are expressed in distinct subpopulations of primary sensory neurons in the dorsal root ganglion (DRG), and play important roles in the differentiation of nociceptive and proprioceptive neurons, respectively. In the present study, we examined the developmental changes of the expression of Runx1 and Runx3 in the mouse DRG during embryonic and postnatal stages. We found that the expression of Runx3 preceded that of Runx1, but dramatically decreased before birth, whereas the Runx1 expression was maintained during postnatal periods. These results suggest that roles of Runx1 and Runx3 may change dynamically in the differentiation and maturation of DRG neurons. In addition, several DRG neurons expressed both Runx1 and Runx3 throughout embryonic and postnatal stages and many Runx3‐expressing DRG neurons coexpressed Runx1 at postnatal day 28. Double and triple labeling studies suggest that some of the Runx1/Runx3‐double expressing neurons coexpressed TrkB, c‐ret, and TrkC, which have been shown in the mechanoreceptive DRG neurons. These results suggest that Runx1/Runx3‐double expressing neurons may represent mechanoreceptive properties in the DRG.© 2013 Wiley Periodicals, Inc. Develop Neurobiol 73: 469–479, 2013</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>23378040</pmid><doi>10.1002/dneu.22073</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Animals, Newborn Core Binding Factor Alpha 2 Subunit - biosynthesis Core Binding Factor Alpha 3 Subunit - biosynthesis Developmental stages DRG Female Ganglia, Spinal - metabolism Gene Expression Regulation mechanoreceptor Mechanoreceptors - metabolism Mice Mice, Inbred C57BL Neurons - metabolism Pregnancy Runx1 Runx3 transcription factor |
| title | Coexpression of Runx1 and Runx3 in mechanoreceptive dorsal root ganglion neurons |
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