Protective Role of Quercetin on Polychlorinated Biphenyls (Aroclor-1254) Induced Oxidative Stress and Apoptosis in Liver of Adult Male Rats
ABSTRACT The present study aims to investigate the protective effect of quercetin against Aroclor‐1254–induced hepatotoxicity in rats. Male Wistar rats were grouped into Group I control received vehicle (corn oil; 1 mL/kg bwt); Group II quercetin alone (50 mg/kg bwt/day orally); Group III Aroclor‐12...
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| Veröffentlicht in: | Journal of biochemical and molecular toxicology 2012-12, Vol.26 (12), p.522-532 |
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| creator | Sekaran, Suganya Kandaswamy, Selvakumar Gunasekaran, Krishnamoorthy Perumal, Elumalai Afsar Basha, Fariya Yasmine Madhan Mohan, Balasakthi Janani Jagadeesan, Arunakaran |
| description | ABSTRACT
The present study aims to investigate the protective effect of quercetin against Aroclor‐1254–induced hepatotoxicity in rats. Male Wistar rats were grouped into Group I control received vehicle (corn oil; 1 mL/kg bwt); Group II quercetin alone (50 mg/kg bwt/day orally); Group III Aroclor‐1254 (2 mg/kg bwt/day intraperitoneally); Group IV Aroclor‐1254 + quercetin treated for 30 days. The Aroclor‐1254 treatment caused significant alteration in the biochemical parameters (hydrogen peroxide, lipid peroxidation, reduced glutathione levels, and alkaline phosphatase activity). The expressions of apoptotic and antiapoptotic proteins and the liver histology of Aroclor‐1254–exposed rats showed cytoplasmic degeneration along with infiltration of polymorphonuclear cells. Whereas simultaneous treatment with quercetin normalized all the biochemical parameters, consequently it inhibited apoptosis mediated by Aroclor‐1254 by downregulating aryl hydrocarbon receptor, p53 and apoptotic protein (Bax, caspase‐9, caspase‐3) and upregulating the antiapoptotic protein (Bcl‐2) expression patterns; thereby, quercetin reduces alteration in hepatocellular morphology. Thus quercetin exhibited hepatoprotective effect. © 2012 Wiley Periodicals, Inc. J BiochemMol Toxicol 26:522‐532, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21466 |
| doi_str_mv | 10.1002/jbt.21466 |
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The present study aims to investigate the protective effect of quercetin against Aroclor‐1254–induced hepatotoxicity in rats. Male Wistar rats were grouped into Group I control received vehicle (corn oil; 1 mL/kg bwt); Group II quercetin alone (50 mg/kg bwt/day orally); Group III Aroclor‐1254 (2 mg/kg bwt/day intraperitoneally); Group IV Aroclor‐1254 + quercetin treated for 30 days. The Aroclor‐1254 treatment caused significant alteration in the biochemical parameters (hydrogen peroxide, lipid peroxidation, reduced glutathione levels, and alkaline phosphatase activity). The expressions of apoptotic and antiapoptotic proteins and the liver histology of Aroclor‐1254–exposed rats showed cytoplasmic degeneration along with infiltration of polymorphonuclear cells. Whereas simultaneous treatment with quercetin normalized all the biochemical parameters, consequently it inhibited apoptosis mediated by Aroclor‐1254 by downregulating aryl hydrocarbon receptor, p53 and apoptotic protein (Bax, caspase‐9, caspase‐3) and upregulating the antiapoptotic protein (Bcl‐2) expression patterns; thereby, quercetin reduces alteration in hepatocellular morphology. Thus quercetin exhibited hepatoprotective effect. © 2012 Wiley Periodicals, Inc. J BiochemMol Toxicol 26:522‐532, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21466</description><identifier>ISSN: 1095-6670</identifier><identifier>EISSN: 1099-0461</identifier><identifier>DOI: 10.1002/jbt.21466</identifier><identifier>PMID: 23281070</identifier><identifier>CODEN: JBMTFQ</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>AhR ; Alkaline Phosphatase - blood ; Animals ; Apoptosis ; Apoptosis - drug effects ; Chlorodiphenyl (54% Chlorine) - toxicity ; Hepatotoxicity ; Liver - drug effects ; Liver - pathology ; Male ; Oxidative Stress ; Oxidative Stress - drug effects ; Polychlorinated Biphenyls ; Quercetin ; Quercetin - pharmacology ; Rats ; Rats, Wistar ; Receptors, Aryl Hydrocarbon - genetics</subject><ispartof>Journal of biochemical and molecular toxicology, 2012-12, Vol.26 (12), p.522-532</ispartof><rights>2012 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4596-9c13f7ba18f42b7f8e54b9a1d1911eda2369a3a110d7bbbda0f0ea10b33c74663</citedby><cites>FETCH-LOGICAL-c4596-9c13f7ba18f42b7f8e54b9a1d1911eda2369a3a110d7bbbda0f0ea10b33c74663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbt.21466$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbt.21466$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23281070$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sekaran, Suganya</creatorcontrib><creatorcontrib>Kandaswamy, Selvakumar</creatorcontrib><creatorcontrib>Gunasekaran, Krishnamoorthy</creatorcontrib><creatorcontrib>Perumal, Elumalai</creatorcontrib><creatorcontrib>Afsar Basha, Fariya Yasmine</creatorcontrib><creatorcontrib>Madhan Mohan, Balasakthi Janani</creatorcontrib><creatorcontrib>Jagadeesan, Arunakaran</creatorcontrib><title>Protective Role of Quercetin on Polychlorinated Biphenyls (Aroclor-1254) Induced Oxidative Stress and Apoptosis in Liver of Adult Male Rats</title><title>Journal of biochemical and molecular toxicology</title><addtitle>J Biochem Mol Toxicol</addtitle><description>ABSTRACT
The present study aims to investigate the protective effect of quercetin against Aroclor‐1254–induced hepatotoxicity in rats. Male Wistar rats were grouped into Group I control received vehicle (corn oil; 1 mL/kg bwt); Group II quercetin alone (50 mg/kg bwt/day orally); Group III Aroclor‐1254 (2 mg/kg bwt/day intraperitoneally); Group IV Aroclor‐1254 + quercetin treated for 30 days. The Aroclor‐1254 treatment caused significant alteration in the biochemical parameters (hydrogen peroxide, lipid peroxidation, reduced glutathione levels, and alkaline phosphatase activity). The expressions of apoptotic and antiapoptotic proteins and the liver histology of Aroclor‐1254–exposed rats showed cytoplasmic degeneration along with infiltration of polymorphonuclear cells. Whereas simultaneous treatment with quercetin normalized all the biochemical parameters, consequently it inhibited apoptosis mediated by Aroclor‐1254 by downregulating aryl hydrocarbon receptor, p53 and apoptotic protein (Bax, caspase‐9, caspase‐3) and upregulating the antiapoptotic protein (Bcl‐2) expression patterns; thereby, quercetin reduces alteration in hepatocellular morphology. Thus quercetin exhibited hepatoprotective effect. © 2012 Wiley Periodicals, Inc. J BiochemMol Toxicol 26:522‐532, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21466</description><subject>AhR</subject><subject>Alkaline Phosphatase - blood</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Chlorodiphenyl (54% Chlorine) - toxicity</subject><subject>Hepatotoxicity</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Oxidative Stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Polychlorinated Biphenyls</subject><subject>Quercetin</subject><subject>Quercetin - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Aryl Hydrocarbon - genetics</subject><issn>1095-6670</issn><issn>1099-0461</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctO3DAUhqOqVaG0i75AZakbWAR8jePlQFsumgKd0nZpObYjPM3EwXaAeQZeGjMDLJCqrs6Rzne-I_svio8I7iII8d68SbsY0ap6VWwiKEQJaYVer3pWVhWHG8W7GOcQQiY4e1tsYIJrBDncLO7Og09WJ3dtwcx3FvgW_Bht0Da5HvgenPtuqS87H1yvkjVg3w2Xtl92EWxPgtd5UCLM6A447s2oM3B264xa-X6mYGMEqjdgMvgh-egiyNZpHoaHQxMzdgl8V_nsTKX4vnjTqi7aD491q_j17evFwVE5PTs8PphMS02ZqEqhEWl5o1DdUtzwtraMNkIhgwRC1ihMKqGIQgga3jSNUbCFViHYEKJ5_iSyVWyvvUPwV6ONSS5c1LbrVG_9GCWihELMCMT_RzEnCIuKiYx-foHO_Rj6_JBMUUwZ53WdqZ01pYOPMdhWDsEtVFhKBOVDmDKHKVdhZvbTo3FsFtY8k0_pZWBvDdy4zi7_bZIn-xdPynK94WKyt88bKvyVFSecyT-nh5LNfp8czfAXWZN7IwC28w</recordid><startdate>201212</startdate><enddate>201212</enddate><creator>Sekaran, Suganya</creator><creator>Kandaswamy, Selvakumar</creator><creator>Gunasekaran, Krishnamoorthy</creator><creator>Perumal, Elumalai</creator><creator>Afsar Basha, Fariya Yasmine</creator><creator>Madhan Mohan, Balasakthi Janani</creator><creator>Jagadeesan, Arunakaran</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201212</creationdate><title>Protective Role of Quercetin on Polychlorinated Biphenyls (Aroclor-1254) Induced Oxidative Stress and Apoptosis in Liver of Adult Male Rats</title><author>Sekaran, Suganya ; Kandaswamy, Selvakumar ; Gunasekaran, Krishnamoorthy ; Perumal, Elumalai ; Afsar Basha, Fariya Yasmine ; Madhan Mohan, Balasakthi Janani ; Jagadeesan, Arunakaran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4596-9c13f7ba18f42b7f8e54b9a1d1911eda2369a3a110d7bbbda0f0ea10b33c74663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>AhR</topic><topic>Alkaline Phosphatase - blood</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Chlorodiphenyl (54% Chlorine) - toxicity</topic><topic>Hepatotoxicity</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Oxidative Stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Polychlorinated Biphenyls</topic><topic>Quercetin</topic><topic>Quercetin - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Aryl Hydrocarbon - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sekaran, Suganya</creatorcontrib><creatorcontrib>Kandaswamy, Selvakumar</creatorcontrib><creatorcontrib>Gunasekaran, Krishnamoorthy</creatorcontrib><creatorcontrib>Perumal, Elumalai</creatorcontrib><creatorcontrib>Afsar Basha, Fariya Yasmine</creatorcontrib><creatorcontrib>Madhan Mohan, Balasakthi Janani</creatorcontrib><creatorcontrib>Jagadeesan, Arunakaran</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biochemical and molecular toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sekaran, Suganya</au><au>Kandaswamy, Selvakumar</au><au>Gunasekaran, Krishnamoorthy</au><au>Perumal, Elumalai</au><au>Afsar Basha, Fariya Yasmine</au><au>Madhan Mohan, Balasakthi Janani</au><au>Jagadeesan, Arunakaran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective Role of Quercetin on Polychlorinated Biphenyls (Aroclor-1254) Induced Oxidative Stress and Apoptosis in Liver of Adult Male Rats</atitle><jtitle>Journal of biochemical and molecular toxicology</jtitle><addtitle>J Biochem Mol Toxicol</addtitle><date>2012-12</date><risdate>2012</risdate><volume>26</volume><issue>12</issue><spage>522</spage><epage>532</epage><pages>522-532</pages><issn>1095-6670</issn><eissn>1099-0461</eissn><coden>JBMTFQ</coden><abstract>ABSTRACT
The present study aims to investigate the protective effect of quercetin against Aroclor‐1254–induced hepatotoxicity in rats. Male Wistar rats were grouped into Group I control received vehicle (corn oil; 1 mL/kg bwt); Group II quercetin alone (50 mg/kg bwt/day orally); Group III Aroclor‐1254 (2 mg/kg bwt/day intraperitoneally); Group IV Aroclor‐1254 + quercetin treated for 30 days. The Aroclor‐1254 treatment caused significant alteration in the biochemical parameters (hydrogen peroxide, lipid peroxidation, reduced glutathione levels, and alkaline phosphatase activity). The expressions of apoptotic and antiapoptotic proteins and the liver histology of Aroclor‐1254–exposed rats showed cytoplasmic degeneration along with infiltration of polymorphonuclear cells. Whereas simultaneous treatment with quercetin normalized all the biochemical parameters, consequently it inhibited apoptosis mediated by Aroclor‐1254 by downregulating aryl hydrocarbon receptor, p53 and apoptotic protein (Bax, caspase‐9, caspase‐3) and upregulating the antiapoptotic protein (Bcl‐2) expression patterns; thereby, quercetin reduces alteration in hepatocellular morphology. Thus quercetin exhibited hepatoprotective effect. © 2012 Wiley Periodicals, Inc. J BiochemMol Toxicol 26:522‐532, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21466</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23281070</pmid><doi>10.1002/jbt.21466</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | AhR Alkaline Phosphatase - blood Animals Apoptosis Apoptosis - drug effects Chlorodiphenyl (54% Chlorine) - toxicity Hepatotoxicity Liver - drug effects Liver - pathology Male Oxidative Stress Oxidative Stress - drug effects Polychlorinated Biphenyls Quercetin Quercetin - pharmacology Rats Rats, Wistar Receptors, Aryl Hydrocarbon - genetics |
| title | Protective Role of Quercetin on Polychlorinated Biphenyls (Aroclor-1254) Induced Oxidative Stress and Apoptosis in Liver of Adult Male Rats |
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