Enhanced  -secretase processing alters APP axonal transport and leads to axonal defects

Alzheimer's disease (AD) is a neurodegenerative disease pathologically characterized by amyloid plaques and neurofibrillary tangles in the brain. Before these hallmark features appear, signs of axonal transport defects develop, though the initiating events are not clear. Enhanced amyloidogenic...

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Veröffentlicht in:	Human molecular genetics 2012-11, Vol.21 (21), p.4587-4601
Hauptverfasser:	Rodrigues, E. M., Weissmiller, A. M., Goldstein, L. S. B.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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