Projections from the paralemniscal nucleus to the spinal cord in the mouse
The present study investigated the projection from the paralemniscal nucleus (PL) to the spinal cord in the mouse by injecting the retrograde tracer fluoro-gold to different levels of the spinal cord and injecting the anterograde tracer biotinylated dextran amine into PL. We found that PL projects t...
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| Veröffentlicht in: | Brain Structure and Function 2013-09, Vol.218 (5), p.1307-1316 |
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| creator | Liang, Huazheng Duan, Deyi Watson, Charles Paxinos, George |
| description | The present study investigated the projection from the paralemniscal nucleus (PL) to the spinal cord in the mouse by injecting the retrograde tracer fluoro-gold to different levels of the spinal cord and injecting the anterograde tracer biotinylated dextran amine into PL. We found that PL projects to the entire spinal cord with obvious contralateral predominance—420 neurons projected to the contralateral cervical cord and 270 to the contralateral lumbar cord. Fibers from PL descended in the dorsolateral funiculus on the contralateral side and terminated in laminae 5, 6, 7, and to a lesser extent in the dorsal and ventral horns. A smaller number of fibers also descended in the ventral funiculus on the ipsilateral side and terminated in laminae 7, 8 and, to a lesser extent in lamina 9. The present study is the first demonstration of the PL fiber termination in the spinal cord in mammals. The PL projection to the spinal cord may be involved in vocalization and locomotion. |
| doi_str_mv | 10.1007/s00429-012-0459-5 |
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We found that PL projects to the entire spinal cord with obvious contralateral predominance—420 neurons projected to the contralateral cervical cord and 270 to the contralateral lumbar cord. Fibers from PL descended in the dorsolateral funiculus on the contralateral side and terminated in laminae 5, 6, 7, and to a lesser extent in the dorsal and ventral horns. A smaller number of fibers also descended in the ventral funiculus on the ipsilateral side and terminated in laminae 7, 8 and, to a lesser extent in lamina 9. The present study is the first demonstration of the PL fiber termination in the spinal cord in mammals. 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Duan, Deyi ; Watson, Charles ; Paxinos, George</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-d3feac1291cbc50a4e34c82f98239e9a53d2be31c1c571272c2e814dfe1a8ed83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Anatomy & physiology</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biotin - analogs & derivatives</topic><topic>Brain</topic><topic>Cell Biology</topic><topic>Dextrans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Immunohistochemistry</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Motor Neurons - cytology</topic><topic>Neuroanatomical Tract-Tracing Techniques - methods</topic><topic>Neurology</topic><topic>Neurons</topic><topic>Neurosciences</topic><topic>Original Article</topic><topic>Pons - cytology</topic><topic>Rodents</topic><topic>Spinal cord</topic><topic>Spinal Cord - cytology</topic><topic>Stilbamidines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liang, Huazheng</creatorcontrib><creatorcontrib>Duan, Deyi</creatorcontrib><creatorcontrib>Watson, Charles</creatorcontrib><creatorcontrib>Paxinos, George</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Brain Structure and Function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Huazheng</au><au>Duan, Deyi</au><au>Watson, Charles</au><au>Paxinos, George</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Projections from the paralemniscal nucleus to the spinal cord in the mouse</atitle><jtitle>Brain Structure and Function</jtitle><stitle>Brain Struct Funct</stitle><addtitle>Brain Struct Funct</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>218</volume><issue>5</issue><spage>1307</spage><epage>1316</epage><pages>1307-1316</pages><issn>1863-2653</issn><eissn>1863-2661</eissn><eissn>0340-2061</eissn><abstract>The present study investigated the projection from the paralemniscal nucleus (PL) to the spinal cord in the mouse by injecting the retrograde tracer fluoro-gold to different levels of the spinal cord and injecting the anterograde tracer biotinylated dextran amine into PL. 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| subjects | Anatomy & physiology Animals Biomedical and Life Sciences Biomedicine Biotin - analogs & derivatives Brain Cell Biology Dextrans Image Processing, Computer-Assisted Immunohistochemistry Mice Mice, Inbred C57BL Motor Neurons - cytology Neuroanatomical Tract-Tracing Techniques - methods Neurology Neurons Neurosciences Original Article Pons - cytology Rodents Spinal cord Spinal Cord - cytology Stilbamidines |
| title | Projections from the paralemniscal nucleus to the spinal cord in the mouse |
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