Disease Modeling Using Embryonic Stem Cells: MeCP2 Regulates Nuclear Size and RNA Synthesis in Neurons

Mutations in the gene encoding the methyl‐CpG‐binding protein MECP2 are the major cause of Rett syndrome, an autism spectrum disorder mainly affecting young females. MeCP2 is an abundant chromatin‐associated protein, but how and when its absence begins to alter brain function is still far from clear...

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