Comparative proteomic analysis suggests that mitochondria are involved in autosomal recessive polycystic kidney disease

Autosomal recessive polycystic kidney disease (ARPKD), characterized by ectatic collecting duct, is an infantile form of PKD occurring in 1 in 20 000 births. Despite having been studied for many years, little is known about the underlying mechanisms. In the current study, we employed, for the first...

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Veröffentlicht in:	Proteomics (Weinheim) 2012-08, Vol.12 (15-16), p.2556-2570
Hauptverfasser:	Li, Qing-Wei, Lu, Xiao-Yan, You, Yong, Sun, Huan, Liu, Xin-Yu, Ai, Jian-Zhong, Tan, Rui-Zhi, Chen, Tie-Lin, Chen, Mian-Zhi, Wang, Hong-Lian, Wei, Yu-Quan, Zhou, Qin
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Autosomal recessive polycystic kidney disease (ARPKD) Biological and medical sciences Biomedicine Birth Blotting, Western Collecting duct Comparative proteomics Computer programs Down-Regulation Female Fundamental and applied biological sciences. Psychology Gene Expression Profiling Gene Knockdown Techniques Gene Regulatory Networks - genetics Genetics HEK293 Cells Humans Immunohistochemistry Infant Kidney diseases Kidneys Male Malformations of the urinary system Medical sciences Miscellaneous Mitochondria Mitochondrial Proteins - chemistry Mitochondrial Proteins - metabolism Nephrology. Urinary tract diseases Polycystic kidney Polycystic Kidney, Autosomal Recessive - genetics Polycystic Kidney, Autosomal Recessive - metabolism Polymerase chain reaction Protein interaction Proteins proteomics Proteomics - methods Receptors, Cell Surface - metabolism Reproducibility of Results Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering - metabolism Signal Transduction - genetics siRNA software Spectrometry, Mass, Electrospray Ionization Therapeutic applications Western blotting
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