Protective effects of puerarin on experimental chronic lead nephrotoxicity in immature female rats

Puerarin (PU), a natural flavonoid, has been reported to possess anti-oxidative and anti-inflammatory activities. In the present study, female Sprague-Dawley rats received lead (Pb) nitrate (300 mg/L, via drinking water) and/or PU (400 mg/kg/day, orally) to investigate the protective effects of PU o...

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Veröffentlicht in:	Human & experimental toxicology 2013-02, Vol.32 (2), p.172-185
Hauptverfasser:	Wang, Lin, Lin, Shuqian, Li, Zifa, Yang, Dubao, Wang, Zhenyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiinflammatory agents Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Creatinine - blood Electron Transport Complex IV - genetics Female Isoflavones - pharmacology Isoflavones - therapeutic use Kidney Diseases - chemically induced Kidney Diseases - drug therapy Kidney Diseases - metabolism Kidney Diseases - pathology Kidneys Lead Lead - blood Lead - pharmacokinetics Lead - toxicity Lead - urine Lead Poisoning - drug therapy Lead Poisoning - metabolism Lead Poisoning - pathology Medical sciences Metals and various inorganic compounds Oxidative stress Protective Agents - pharmacology Protective Agents - therapeutic use Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Rodents Toxicity Toxicology Urea - blood
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