Maraviroc treatment in non-R5-HIV-1-infected patients results in the selection of extreme CXCR4-using variants with limited effect on the total viral setpoint

Using deep sequencing methods, we intensively investigated the selective pressure of maraviroc on the viral population in four patients with dual/mixed HIV-1 experiencing treatment failure. Patients received maraviroc add-on therapy (n = 4). Tropism was determined by Monogram's Trofile assay an...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2013-09, Vol.68 (9), p.2007-2014
Hauptverfasser:	McGovern, Rachel A, Symons, Jori, Poon, Art F Y, Harrigan, P Richard, van Lelyveld, Steven F L, Hoepelman, Andy I M, van Ham, Petra M, Dong, Winnie, Wensing, Annemarie M J, Nijhuis, Monique
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Anti-HIV Agents - therapeutic use Antiretroviral drugs Cohort Studies Cyclohexanes - therapeutic use High-Throughput Nucleotide Sequencing HIV HIV Infections - drug therapy HIV Infections - virology HIV-1 - genetics HIV-1 - isolation & purification HIV-1 - physiology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Longitudinal Studies Pharmacology Receptors, CCR5 - metabolism Receptors, CXCR4 - metabolism Receptors, HIV - metabolism Ribonucleic acid RNA Selection, Genetic Triazoles - therapeutic use Viral Tropism
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