CD44 is required for the migration of transplanted oligodendrocyte progenitor cells to focal inflammatory demyelinating lesions in the spinal cord

Remyelination of chronically demyelinated axons in multiple sclerosis (MS) requires the recruitment of endogenous cells or their replacement by transplanted, exogenous oligodendrocyte progenitor cells (OPCs). We have previously shown that an OPC line, CG4, preferentially migrates after transplantati...

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Veröffentlicht in:	Glia 2013-03, Vol.61 (3), p.361-367
Hauptverfasser:	Piao, Jing-Hua, Wang, Yanping, Duncan, Ian D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons Cell Movement - physiology Demyelinating Diseases - metabolism Demyelinating Diseases - pathology demyelination Female Hyaluronan Receptors - genetics Hyaluronan Receptors - metabolism Myelin Sheath - metabolism Myelin Sheath - pathology Myelin Sheath - transplantation Nerve Regeneration - physiology Neural Stem Cells - cytology Neural Stem Cells - metabolism Neural Stem Cells - transplantation Oligodendroglia - cytology Oligodendroglia - metabolism Oligodendroglia - transplantation OPCs/CG4 Rats Rats, Sprague-Dawley Spinal Cord - metabolism Spinal Cord - pathology transplantation zymosan
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