Cell death and neuronal differentiation of glioblastoma stem-like cells induced by neurogenic transcription factors

Glioblastoma multiform (GBM) are devastating brain tumors containing a fraction of multipotent stem‐like cells which are highly tumorigenic. These cells are resistant to treatments and are likely to be responsible for tumor recurrence. One approach to eliminate GBM stem‐like cells would be to force...

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Veröffentlicht in:	Glia 2013-02, Vol.61 (2), p.225-239
Hauptverfasser:	Guichet, Pierre-Olivier, Bieche, Ivan, Teigell, Marisa, Serguera, Ché, Rothhut, Bernard, Rigau, Valérie, Scamps, Frédérique, Ripoll, Chantal, Vacher, Sophie, Taviaux, Sylvie, Chevassus, Hugues, Duffau, Hugues, Mallet, Jacques, Susini, Aurélie, Joubert, Dominique, Bauchet, Luc, Hugnot, Jean-Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Antigens, CD - metabolism Basic Helix-Loop-Helix Transcription Factors - metabolism Basic Helix-Loop-Helix Transcription Factors - pharmacology Brain Neoplasms - pathology Cell Death Cell Differentiation Flow Cytometry Gene Expression Regulation, Neoplastic Glial Fibrillary Acidic Protein - metabolism glioblastoma Glioblastoma - pathology glioma Glycoproteins - metabolism Hedgehog Proteins - metabolism Humans Neoplastic Stem Cells - drug effects Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - pharmacology neurons Oligodendrocyte Transcription Factor 2 Oncogene Protein p55(v-myc) - metabolism Peptides - metabolism SOXB1 Transcription Factors - metabolism therapy transcription factors Transcription Factors - pharmacology Transfection Tumor Cells, Cultured
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