The soluble isoform of CTLA‐4 as a regulator of T‐cell responses

CTLA‐4 is a crucial immune regulator that mediates both negative costimulation signals to T cells, and regulatory T (Treg)‐cell extrinsic control of effector responses. Here we present evidence supporting a novel mechanism for this extrinsic suppression, executed by the alternatively spliced soluble...

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Veröffentlicht in:	European journal of immunology 2013-05, Vol.43 (5), p.1274-1285
Hauptverfasser:	Ward, Frank J., Dahal, Lekh N., Wijesekera, Subadra K., Abdul‐Jawad, Sultan K., Kaewarpai, Taniya, Xu, Heping, Vickers, Mark A., Barker, Robert N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neutralizing - pharmacology CD4+ T cells Cells, Cultured Costimulatory molecules CTLA-4 Antigen - antagonists & inhibitors CTLA-4 Antigen - genetics CTLA-4 Antigen - immunology Female Humans Immune regulation Interferon-gamma - biosynthesis Interferon-gamma - immunology Interleukin-17 - biosynthesis Interleukin-17 - immunology Lymphocytes Medical research Melanoma, Experimental - drug therapy Melanoma, Experimental - genetics Melanoma, Experimental - immunology Melanoma, Experimental - pathology Mice Mice, Inbred BALB C Neoplasm Metastasis - prevention & control Protein Isoforms - antagonists & inhibitors Protein Isoforms - genetics Protein Isoforms - immunology Signal Transduction - drug effects Signal Transduction - immunology Solubility T-Lymphocytes, Cytotoxic - cytology T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Treg cells
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