Tumor-derived exosomes and microvesicles in head and neck cancer: Implications for tumor biology and biomarker discovery
Exosomes and microvesicles (MVs) are nanometer‐sized, membranous vesicles secreted from many cell types into their surrounding extracellular space and into body fluids. These two classes of extracellular vesicles are regarded as a novel mechanism through which cancer cells, including virally infecte...
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Veröffentlicht in: | Proteomics (Weinheim) 2013-05, Vol.13 (10-11), p.1608-1623 |
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creator | Principe, Simona Hui, Angela Bik-Yu Bruce, Jeff Sinha, Ankit Liu, Fei-Fei Kislinger, Thomas |
description | Exosomes and microvesicles (MVs) are nanometer‐sized, membranous vesicles secreted from many cell types into their surrounding extracellular space and into body fluids. These two classes of extracellular vesicles are regarded as a novel mechanism through which cancer cells, including virally infected cancer cells, regulate their micro‐environment via the horizontal transfer of bioactive molecules: proteins, lipids, and nucleic acids (DNA, mRNA, micro‐RNAs; oncogenic cargo hence often referred to as oncosomes). In head and neck cancer (HNC), exosomes and MVs have been described in Epstein Barr Virus (EBV)‐associated nasopharyngeal cancer (NPC), as well as being positively correlated with oral squamous cell carcinoma (OSCC) progression. It has therefore been suggested that HNC‐derived vesicles could represent a useful source for biomarker discovery, enriched in tumor antigens and cargo; hence fundamentally important for cancer progression. This current review offers an overall perspective on the roles of exosomes and MVs in HNC biology, focusing on EBV‐associated NPC and OSCC. We also highlight the importance of saliva as a proximal and easily accessible bio‐fluid for HNC detection, and propose that salivary vesicles might serve as an alternative model in the discovery of novel HNC biomarkers. |
doi_str_mv | 10.1002/pmic.201200533 |
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These two classes of extracellular vesicles are regarded as a novel mechanism through which cancer cells, including virally infected cancer cells, regulate their micro‐environment via the horizontal transfer of bioactive molecules: proteins, lipids, and nucleic acids (DNA, mRNA, micro‐RNAs; oncogenic cargo hence often referred to as oncosomes). In head and neck cancer (HNC), exosomes and MVs have been described in Epstein Barr Virus (EBV)‐associated nasopharyngeal cancer (NPC), as well as being positively correlated with oral squamous cell carcinoma (OSCC) progression. It has therefore been suggested that HNC‐derived vesicles could represent a useful source for biomarker discovery, enriched in tumor antigens and cargo; hence fundamentally important for cancer progression. This current review offers an overall perspective on the roles of exosomes and MVs in HNC biology, focusing on EBV‐associated NPC and OSCC. We also highlight the importance of saliva as a proximal and easily accessible bio‐fluid for HNC detection, and propose that salivary vesicles might serve as an alternative model in the discovery of novel HNC biomarkers.</description><identifier>ISSN: 1615-9853</identifier><identifier>EISSN: 1615-9861</identifier><identifier>DOI: 10.1002/pmic.201200533</identifier><identifier>PMID: 23505015</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Animals ; Biomarkers, Tumor - metabolism ; Biomedicine ; Cancer ; Cell-Derived Microparticles - metabolism ; Cell-Derived Microparticles - virology ; Epstein-Barr virus ; Exosome ; Exosomes - metabolism ; Exosomes - virology ; Head and Neck Neoplasms - metabolism ; Head and Neck Neoplasms - virology ; Herpesvirus 4, Human - genetics ; Humans ; MicroRNAs - metabolism ; miRNA ; Proteome - isolation & purification ; Proteome - metabolism ; RNA, Viral - metabolism ; Saliva - metabolism</subject><ispartof>Proteomics (Weinheim), 2013-05, Vol.13 (10-11), p.1608-1623</ispartof><rights>2013 WILEY‐VCH Verlag GmbH & Co. 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These two classes of extracellular vesicles are regarded as a novel mechanism through which cancer cells, including virally infected cancer cells, regulate their micro‐environment via the horizontal transfer of bioactive molecules: proteins, lipids, and nucleic acids (DNA, mRNA, micro‐RNAs; oncogenic cargo hence often referred to as oncosomes). In head and neck cancer (HNC), exosomes and MVs have been described in Epstein Barr Virus (EBV)‐associated nasopharyngeal cancer (NPC), as well as being positively correlated with oral squamous cell carcinoma (OSCC) progression. It has therefore been suggested that HNC‐derived vesicles could represent a useful source for biomarker discovery, enriched in tumor antigens and cargo; hence fundamentally important for cancer progression. This current review offers an overall perspective on the roles of exosomes and MVs in HNC biology, focusing on EBV‐associated NPC and OSCC. We also highlight the importance of saliva as a proximal and easily accessible bio‐fluid for HNC detection, and propose that salivary vesicles might serve as an alternative model in the discovery of novel HNC biomarkers.</description><subject>Animals</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Cell-Derived Microparticles - metabolism</subject><subject>Cell-Derived Microparticles - virology</subject><subject>Epstein-Barr virus</subject><subject>Exosome</subject><subject>Exosomes - metabolism</subject><subject>Exosomes - virology</subject><subject>Head and Neck Neoplasms - metabolism</subject><subject>Head and Neck Neoplasms - virology</subject><subject>Herpesvirus 4, Human - genetics</subject><subject>Humans</subject><subject>MicroRNAs - metabolism</subject><subject>miRNA</subject><subject>Proteome - isolation & purification</subject><subject>Proteome - metabolism</subject><subject>RNA, Viral - metabolism</subject><subject>Saliva - metabolism</subject><issn>1615-9853</issn><issn>1615-9861</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtPGzEURq2qiFfZdom87GaCPX7NsENRA5F4iYJYWrbnTmuYGad2Asm_xyGQLStb9vmO7Psh9JOSESWkPJn13o1KQktCBGPf0D6VVBR1Jen37V6wPXSQ0hMhVFW12kV7JRNEECr20fJ-0YdYNBD9CzQYliGFHhI2Q4OzOoYXSN51-cQP-B-Y5v1mAPeMnRkcxFM87Wedd2buw5BwGyKer5XY-tCFv6t3Pu97E58h4sYnl51x9QPttKZLcPSxHqKHye_78UVxeXM-HZ9dFo4rRQrTyNaxti6BVcw66rjhLTimFLeikm3tpJCqgrKmwMC2qnTSWttYW9VcWcEO0a-NdxbD_wWkue7zE6DrzABhkTTljBNayaz_EmUyj00QXmZ0tEHzhFKK0OpZ9PmLK02JXhej18XobTE5cPzhXtgemi3-2UQG-AZ49R2svtDp26vpWHFKcqzYxHyaw3Iby8PWUjEl9OP1ub6S4z-TOzHR1-wNVviqpA</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>Principe, Simona</creator><creator>Hui, Angela Bik-Yu</creator><creator>Bruce, Jeff</creator><creator>Sinha, Ankit</creator><creator>Liu, Fei-Fei</creator><creator>Kislinger, Thomas</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201305</creationdate><title>Tumor-derived exosomes and microvesicles in head and neck cancer: Implications for tumor biology and biomarker discovery</title><author>Principe, Simona ; Hui, Angela Bik-Yu ; Bruce, Jeff ; Sinha, Ankit ; Liu, Fei-Fei ; Kislinger, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4770-ad6fc3f92e383bc1c4a4fec3774b586f9c65678e291e3ebf72c6bbbdbb8947b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Biomedicine</topic><topic>Cancer</topic><topic>Cell-Derived Microparticles - metabolism</topic><topic>Cell-Derived Microparticles - virology</topic><topic>Epstein-Barr virus</topic><topic>Exosome</topic><topic>Exosomes - metabolism</topic><topic>Exosomes - virology</topic><topic>Head and Neck Neoplasms - metabolism</topic><topic>Head and Neck Neoplasms - virology</topic><topic>Herpesvirus 4, Human - genetics</topic><topic>Humans</topic><topic>MicroRNAs - metabolism</topic><topic>miRNA</topic><topic>Proteome - isolation & purification</topic><topic>Proteome - metabolism</topic><topic>RNA, Viral - metabolism</topic><topic>Saliva - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Principe, Simona</creatorcontrib><creatorcontrib>Hui, Angela Bik-Yu</creatorcontrib><creatorcontrib>Bruce, Jeff</creatorcontrib><creatorcontrib>Sinha, Ankit</creatorcontrib><creatorcontrib>Liu, Fei-Fei</creatorcontrib><creatorcontrib>Kislinger, Thomas</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Proteomics (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Principe, Simona</au><au>Hui, Angela Bik-Yu</au><au>Bruce, Jeff</au><au>Sinha, Ankit</au><au>Liu, Fei-Fei</au><au>Kislinger, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor-derived exosomes and microvesicles in head and neck cancer: Implications for tumor biology and biomarker discovery</atitle><jtitle>Proteomics (Weinheim)</jtitle><addtitle>Proteomics</addtitle><date>2013-05</date><risdate>2013</risdate><volume>13</volume><issue>10-11</issue><spage>1608</spage><epage>1623</epage><pages>1608-1623</pages><issn>1615-9853</issn><eissn>1615-9861</eissn><abstract>Exosomes and microvesicles (MVs) are nanometer‐sized, membranous vesicles secreted from many cell types into their surrounding extracellular space and into body fluids. These two classes of extracellular vesicles are regarded as a novel mechanism through which cancer cells, including virally infected cancer cells, regulate their micro‐environment via the horizontal transfer of bioactive molecules: proteins, lipids, and nucleic acids (DNA, mRNA, micro‐RNAs; oncogenic cargo hence often referred to as oncosomes). In head and neck cancer (HNC), exosomes and MVs have been described in Epstein Barr Virus (EBV)‐associated nasopharyngeal cancer (NPC), as well as being positively correlated with oral squamous cell carcinoma (OSCC) progression. It has therefore been suggested that HNC‐derived vesicles could represent a useful source for biomarker discovery, enriched in tumor antigens and cargo; hence fundamentally important for cancer progression. This current review offers an overall perspective on the roles of exosomes and MVs in HNC biology, focusing on EBV‐associated NPC and OSCC. 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subjects | Animals Biomarkers, Tumor - metabolism Biomedicine Cancer Cell-Derived Microparticles - metabolism Cell-Derived Microparticles - virology Epstein-Barr virus Exosome Exosomes - metabolism Exosomes - virology Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - virology Herpesvirus 4, Human - genetics Humans MicroRNAs - metabolism miRNA Proteome - isolation & purification Proteome - metabolism RNA, Viral - metabolism Saliva - metabolism |
title | Tumor-derived exosomes and microvesicles in head and neck cancer: Implications for tumor biology and biomarker discovery |
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