Positive feedback loop via astrocytes causes chronic inflammation in virus-associated myelopathy

Human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a rare neurodegenerative disease characterized by chronic inflammation in the spinal cord. We hypothesized that a positive feedback loop driven by chemokines may be responsible for the chronic inflammat...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2013-09, Vol.136 (Pt 9), p.2876-2887
Hauptverfasser:	ANDO, Hitoshi, SATO, Tomoo, YUDOH, Kazuo, HASEGAWA, Yasuhiro, NISHIOKA, Kusuki, NAKAJIMA, Toshihiro, JACOBSON, Steven, YAMANO, Yoshihisa, TOMARU, Utano, YOSHIDA, Mari, UTSUNOMIYA, Atae, YAMAUCHI, Junji, ARAYA, Natsumi, YAGISHITA, Naoko, COLER-REILLY, Ariella, SHIMIZU, Yukiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies - pharmacology Astrocytes - metabolism Astrocytes - pathology Biological and medical sciences Cell Proliferation Cells, Cultured Chemokines - immunology Chemokines - metabolism Chemotaxis, Leukocyte - physiology Female Flow Cytometry Glial Fibrillary Acidic Protein - metabolism HTLV-I Infections - cerebrospinal fluid HTLV-I Infections - complications Human T-lymphotropic virus Human T-lymphotropic virus 1 Human viral diseases Humans Infectious diseases Inflammation - cerebrospinal fluid Inflammation - etiology Inflammation - pathology Leukocytes, Mononuclear Male Medical sciences Middle Aged Neurology Paraparesis, Tropical Spastic - complications Paraparesis, Tropical Spastic - etiology Paraparesis, Tropical Spastic - virology Time Factors Viral diseases Viral diseases of the nervous system
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