Expression of EphA8‐Fc in transgenic mouse embryos induces apoptosis of neural epithelial cells during brain development

ABSTRACT EphAs and ephrin‐As are expressed in multiple regions of the developing brain and have been implicated in regulating brain size. Here, we report the identification of a novel mechanism in which reverse signaling through ephrin‐As controls neural epithelial cell number in the developing brai...

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Veröffentlicht in:	Developmental neurobiology (Hoboken, N.J.) N.J.), 2013-09, Vol.73 (9), p.702-712
Hauptverfasser:	Kim, Yujin, Park, Eunjeong, Noh, Hyuna, Park, Soochul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - physiology Brain - cytology Brain - embryology Brain - metabolism Caspase 3 - metabolism Cells, Cultured Chromosomes, Artificial, Bacterial early brain development EphA Ephrin-A5 - genetics Ephrin-A5 - metabolism ephrin‐A Mice Mice, Transgenic Neuroepithelial Cells - metabolism Receptor, EphA8 - metabolism
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