Probiotics—Interactions with Bile Acids and Impact on Cholesterol Metabolism
The use of probiotics, alone or in interaction with bile acids, is a modern strategy in the prevention and treatment of hypercholesterolemia. Numerous mechanisms for hypocholesterolemic effect of probiotics have been hypothesized, based mostly on in vitro evidence. Interaction with bile acids throug...
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| Veröffentlicht in: | Applied biochemistry and biotechnology 2012-12, Vol.168 (7), p.1880-1895 |
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| container_title | Applied biochemistry and biotechnology |
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| creator | Pavlović, Nebojša Stankov, Karmen Mikov, Momir |
| description | The use of probiotics, alone or in interaction with bile acids, is a modern strategy in the prevention and treatment of hypercholesterolemia. Numerous mechanisms for hypocholesterolemic effect of probiotics have been hypothesized, based mostly on in vitro evidence. Interaction with bile acids through reaction of deconjugation catalyzed by bile salt hydrolase enzymes (BSH) is considered as the main mechanism of cholesterol-lowering effects of probiotic bacteria, but it has been reported that microbial BSH activity could be potentially detrimental to the human host. There are several approaches for prevention of possible side effects associated with BSH activity, which at the same time increase the viability of probiotics in the intestines and also in food matrices. The aim of our study was to summarize present knowledge of probiotics—bile acids interactions, with special reference to cholesterol-lowering mechanisms of probiotics, and to report novel biotechnological approaches for increasing the pharmacological benefits of probiotics. |
| doi_str_mv | 10.1007/s12010-012-9904-4 |
| format | Article |
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Numerous mechanisms for hypocholesterolemic effect of probiotics have been hypothesized, based mostly on in vitro evidence. Interaction with bile acids through reaction of deconjugation catalyzed by bile salt hydrolase enzymes (BSH) is considered as the main mechanism of cholesterol-lowering effects of probiotic bacteria, but it has been reported that microbial BSH activity could be potentially detrimental to the human host. There are several approaches for prevention of possible side effects associated with BSH activity, which at the same time increase the viability of probiotics in the intestines and also in food matrices. The aim of our study was to summarize present knowledge of probiotics—bile acids interactions, with special reference to cholesterol-lowering mechanisms of probiotics, and to report novel biotechnological approaches for increasing the pharmacological benefits of probiotics.</description><identifier>ISSN: 0273-2289</identifier><identifier>EISSN: 1559-0291</identifier><identifier>DOI: 10.1007/s12010-012-9904-4</identifier><identifier>PMID: 23054820</identifier><identifier>CODEN: ABIBDL</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Animals ; Anticholesteremic Agents - adverse effects ; Anticholesteremic Agents - metabolism ; Anticholesteremic Agents - pharmacology ; Anticholesteremic Agents - therapeutic use ; Bile Acids and Salts - metabolism ; Biochemistry ; Biological and medical sciences ; Biotechnology ; Chemistry ; Chemistry and Materials Science ; Cholesterol ; Cholesterol - blood ; Cholesterol - metabolism ; Diabetes Mellitus - drug therapy ; Diabetes Mellitus - metabolism ; Drug Delivery Systems ; Fundamental and applied biological sciences. Psychology ; Humans ; Pharmacology ; Prevention ; Probiotics ; Probiotics - adverse effects ; Probiotics - metabolism ; Probiotics - pharmacology ; Probiotics - therapeutic use</subject><ispartof>Applied biochemistry and biotechnology, 2012-12, Vol.168 (7), p.1880-1895</ispartof><rights>Springer Science+Business Media New York 2012</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-9043e950dd9d54a382e29968ef215b3bb0f6d5ac2bd0030afed1d063582ebeae3</citedby><cites>FETCH-LOGICAL-c402t-9043e950dd9d54a382e29968ef215b3bb0f6d5ac2bd0030afed1d063582ebeae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12010-012-9904-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12010-012-9904-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26728001$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23054820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pavlović, Nebojša</creatorcontrib><creatorcontrib>Stankov, Karmen</creatorcontrib><creatorcontrib>Mikov, Momir</creatorcontrib><title>Probiotics—Interactions with Bile Acids and Impact on Cholesterol Metabolism</title><title>Applied biochemistry and biotechnology</title><addtitle>Appl Biochem Biotechnol</addtitle><addtitle>Appl Biochem Biotechnol</addtitle><description>The use of probiotics, alone or in interaction with bile acids, is a modern strategy in the prevention and treatment of hypercholesterolemia. Numerous mechanisms for hypocholesterolemic effect of probiotics have been hypothesized, based mostly on in vitro evidence. Interaction with bile acids through reaction of deconjugation catalyzed by bile salt hydrolase enzymes (BSH) is considered as the main mechanism of cholesterol-lowering effects of probiotic bacteria, but it has been reported that microbial BSH activity could be potentially detrimental to the human host. There are several approaches for prevention of possible side effects associated with BSH activity, which at the same time increase the viability of probiotics in the intestines and also in food matrices. The aim of our study was to summarize present knowledge of probiotics—bile acids interactions, with special reference to cholesterol-lowering mechanisms of probiotics, and to report novel biotechnological approaches for increasing the pharmacological benefits of probiotics.</description><subject>Animals</subject><subject>Anticholesteremic Agents - adverse effects</subject><subject>Anticholesteremic Agents - metabolism</subject><subject>Anticholesteremic Agents - pharmacology</subject><subject>Anticholesteremic Agents - therapeutic use</subject><subject>Bile Acids and Salts - metabolism</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Cholesterol - metabolism</subject><subject>Diabetes Mellitus - drug therapy</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Drug Delivery Systems</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Pharmacology</subject><subject>Prevention</subject><subject>Probiotics</subject><subject>Probiotics - adverse effects</subject><subject>Probiotics - metabolism</subject><subject>Probiotics - pharmacology</subject><subject>Probiotics - therapeutic use</subject><issn>0273-2289</issn><issn>1559-0291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp10c1O3DAUBWALFcHw8wBsqkioEpvQ62s7Ey9hBO1IQFnA2nJspxgl8WBnVHXHQ_CEPAlGMwWE1JUX9_P10TEhBxSOKcD0e6IIFEqgWEoJvOQbZEKFkCWgpF_IBHDKSsRabpOdlO4hw1pMt8g2MhC8RpiQq-sYGh9Gb9Lz49N8GF3UZvRhSMUfP94Vp75zxYnxNhV6sMW8X-RxEYZidhc6lzIPXXHpRt2Ezqd-j2y2uktuf33uktvzs5vZz_Li14_57OSiNBxwLHNY5qQAa6UVXLMaHUpZ1a5FKhrWNNBWVmiDjQVgoFtnqYWKiQwbpx3bJUervYsYHpY5h-p9Mq7r9ODCMinKGQdaUQGZHn6i92EZh5xOUawqzgVgnRVdKRNDStG1ahF9r-NfRUG9lq1WZavcoXotW_F85-t687LpnX278a_dDL6tgU5Gd23Ug_Hp3VVTrPOnZIcrl_Jo-O3ih4j_ff0FoxqWnw</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Pavlović, Nebojša</creator><creator>Stankov, Karmen</creator><creator>Mikov, Momir</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7ST</scope><scope>7T7</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>SOI</scope><scope>7QL</scope><scope>7QO</scope></search><sort><creationdate>20121201</creationdate><title>Probiotics—Interactions with Bile Acids and Impact on Cholesterol Metabolism</title><author>Pavlović, Nebojša ; Stankov, Karmen ; Mikov, Momir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-9043e950dd9d54a382e29968ef215b3bb0f6d5ac2bd0030afed1d063582ebeae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Anticholesteremic Agents - adverse effects</topic><topic>Anticholesteremic Agents - metabolism</topic><topic>Anticholesteremic Agents - pharmacology</topic><topic>Anticholesteremic Agents - therapeutic use</topic><topic>Bile Acids and Salts - metabolism</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Cholesterol</topic><topic>Cholesterol - blood</topic><topic>Cholesterol - metabolism</topic><topic>Diabetes Mellitus - drug therapy</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Drug Delivery Systems</topic><topic>Fundamental and applied biological sciences. 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| identifier | ISSN: 0273-2289 |
| ispartof | Applied biochemistry and biotechnology, 2012-12, Vol.168 (7), p.1880-1895 |
| issn | 0273-2289 1559-0291 |
| language | eng |
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| subjects | Animals Anticholesteremic Agents - adverse effects Anticholesteremic Agents - metabolism Anticholesteremic Agents - pharmacology Anticholesteremic Agents - therapeutic use Bile Acids and Salts - metabolism Biochemistry Biological and medical sciences Biotechnology Chemistry Chemistry and Materials Science Cholesterol Cholesterol - blood Cholesterol - metabolism Diabetes Mellitus - drug therapy Diabetes Mellitus - metabolism Drug Delivery Systems Fundamental and applied biological sciences. Psychology Humans Pharmacology Prevention Probiotics Probiotics - adverse effects Probiotics - metabolism Probiotics - pharmacology Probiotics - therapeutic use |
| title | Probiotics—Interactions with Bile Acids and Impact on Cholesterol Metabolism |
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