Characterization of the effects of opiorphin and sialorphin and their analogs substituted in position 1 with pyroglutamic acid on motility in the mouse ileum

Opiorphin and sialorphin are two recently discovered endogenous enkephalin‐degrading enzyme inhibitors. Our aim was to characterize their effect on the mouse ileum motility and to investigate the role of glutamine in position 1. Opiorphin, sialorphin, and their analogs substituted in position 1 with...

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Veröffentlicht in:	Journal of peptide science 2013-03, Vol.19 (3), p.166-172
Hauptverfasser:	Kamysz, Elżbieta, Sałaga, Maciej, Sobczak, Marta, Kamysz, Wojciech, Fichna, Jakub
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models of gastrointestinal motility Animals Dose-Response Relationship, Drug enkephalins Gastrointestinal Transit - drug effects Ileum - drug effects Ileum - physiology In Vitro Techniques Male Mice Mice, Inbred C57BL mouse ileum Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - physiology Oligopeptides - pharmacology Oligopeptides - physiology opiorphin Peptides Protein Precursors - pharmacology Protein Precursors - physiology Rats Salivary Proteins and Peptides - pharmacology Salivary Proteins and Peptides - physiology sialorphin Structure-Activity Relationship structure-activity relationship studies
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