Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments

New phenotypes of single-nucleotide polymorphisms are revealed by analyzing single cells from different individuals rather than bulk cell samples. Gene expression in multiple individual cells from a tissue or culture sample varies according to cell-cycle, genetic, epigenetic and stochastic differenc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature biotechnology 2013-08, Vol.31 (8), p.748-752
Hauptverfasser:	Wills, Quin F, Livak, Kenneth J, Tipping, Alex J, Enver, Tariq, Goldson, Andrew J, Sexton, Darren W, Holmes, Chris
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/199 631/553/2707 Agriculture Analysis Bioinformatics Biomedical Engineering/Biotechnology Biomedicine Biotechnology Cell cycle Chromosome Mapping Gene Expression Gene Expression Profiling Genetic aspects Genetic Association Studies Genetic diversity Genetic variation Humans letter Life Sciences Oligonucleotide Array Sequence Analysis Polymorphism, Single Nucleotide Quantitative Trait Loci - genetics Single-Cell Analysis Tissues Wnt proteins Wnt Signaling Pathway - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!