Near-infrared and two-dimensional fluorescence spectroscopy monitoring of monoclonal antibody fermentation media quality: Aged media decreases cell growth

In biomanufacturing processes, the influence of feedstock components on product yield and quality is considerable and often poorly understood. Here we describe the capabilities of near‐infrared spectroscopy (NIRS) and two dimensional (2D)‐fluorescence spectroscopy in detecting chemical changes over...

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Veröffentlicht in:	Biotechnology journal 2013-07, Vol.8 (7), p.835-846
Hauptverfasser:	Hakemeyer, Christian, Strauss, Ulrike, Werz, Silke, Folque, Francisca, Menezes, Jose C.
Format:	Artikel
Sprache:	eng
Schlagworte:	2D-fluorescence spectroscopy Aging Aging effects Animals Antibodies, Monoclonal - metabolism Cell Culture Techniques - methods CHO Cells Cricetinae Cricetulus Culture Media Fermentation Media components Monoclonal antibody cultivation Near-infrared spectroscopy Principal Component Analysis Spectrometry, Fluorescence - methods Spectroscopy, Near-Infrared Time Factors
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