Determination of Mycophenolic acid in the vitreous humor using the HPLC–ESI-MS/MS method: Application of intraocular pharmacokinetics study in rabbit eyes with ophthalmic implantable device

•Determination of Mycophenolic acid in vitreo.•A sensitive LC–ESI-MS/MS method for the determination of MPA.•Intraocular pharmacokinetics study.•Ophthalmic drug delivery.•Ophthalmic implantable device. Mycophenolic acid (MPA) is an immunosuppressive agent widely used in the treatment of solid organ...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2013-10, Vol.84, p.30-35
Hauptverfasser:	Martins Duarte Byrro, Ricardo, de Oliveira Fulgêncio, Gustavo, Rocha Chellini, Paula, da Silva Cunha, Armando, Pianetti, Gerson Antônio
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorbable Implants acetic acid Animals bioavailability biodegradability Chromatography, High Pressure Liquid - methods Controlled release Drug Delivery Systems - methods drugs eye diseases eyes Female graft rejection HPLC–ESI-MS/MS Immunosuppressive Agents - chemistry Immunosuppressive Agents - pharmacokinetics ionization methanol Mycophenolic acid Mycophenolic Acid - analysis Mycophenolic Acid - chemistry Mycophenolic Acid - pharmacokinetics Ophthalmic drug delivery organ transplantation pharmacokinetics Rabbits Spectrometry, Mass, Electrospray Ionization - methods tandem mass spectrometry Tandem Mass Spectrometry - methods Vitreo drug definition Vitreous Body - chemistry Vitreous Body - metabolism
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