Choline and mica dust induced pulmonary lesions in rats

The effects of mica dust injected intratracheally and parenteral administration of choline were studied in the lungs of albino rats. The intraperitoneal administration of choline (25 mg, 5 days/week) for 10 weeks caused dilation of lymphatic vessels along with adenomatoid changes in the lungs at 330...

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Veröffentlicht in:	Industrial health 1985, Vol.23 (2), p.135-144
Hauptverfasser:	Sahu, A P, Singh, K P, Shukla, L J, Shanker, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - etiology Aluminum Silicates - toxicity Animals Choline - pharmacology Lung - drug effects Lung - pathology Lung Neoplasms - etiology Male Pulmonary Fibrosis - etiology Rats
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creator	Sahu, A P Singh, K P Shukla, L J Shanker, R
description	The effects of mica dust injected intratracheally and parenteral administration of choline were studied in the lungs of albino rats. The intraperitoneal administration of choline (25 mg, 5 days/week) for 10 weeks caused dilation of lymphatic vessels along with adenomatoid changes in the lungs at 330 days. Mica alone (25 mg, intratracheal) provoked pulmonary fibrotic lesions with dilation of lymphatic vessels at 330 days. However, the combined action of mica dust and choline produced adenocarcinoma of bronchiolar epithelium at the termination of the experiment (330 days). Choline as an integral part of cell membrane, its possible role in enhancing the reaction in the lungs exposed to mica dust is discussed.
doi_str_mv	10.2486/indhealth.23.135
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The intraperitoneal administration of choline (25 mg, 5 days/week) for 10 weeks caused dilation of lymphatic vessels along with adenomatoid changes in the lungs at 330 days. Mica alone (25 mg, intratracheal) provoked pulmonary fibrotic lesions with dilation of lymphatic vessels at 330 days. However, the combined action of mica dust and choline produced adenocarcinoma of bronchiolar epithelium at the termination of the experiment (330 days). 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source	MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese
subjects	Adenocarcinoma - etiology Aluminum Silicates - toxicity Animals Choline - pharmacology Lung - drug effects Lung - pathology Lung Neoplasms - etiology Male Pulmonary Fibrosis - etiology Rats
title	Choline and mica dust induced pulmonary lesions in rats
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