$Tumor promoter-induced refractory state against ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate in mouse epidermis$

Tumor promoter-induced refractory state against ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate in mouse epidermis

More than one application of the potent tumor-promoting agent, 12-O-tetradecanoylphorbol-13-acetate (TPA), to mouse skin at intervals of more than 48 h led to a larger induction of ornithine decarboxylase (EC 4.1.1.17; ODC) than did a single application. In contrast, at intervals of less than 24 h,...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1986, Vol.46 (1), p.106-112
Hauptverfasser:	TAKIGAWA, M, SIMSIMAN, R. C, BOUTWELL, R. K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetone - pharmacology Alkynes - pharmacology Animals Biological and medical sciences Carcinogens - pharmacology Cycloheximide - pharmacology Diterpenes Dose-Response Relationship, Drug Drug Administration Schedule Enzyme Induction - drug effects Epidermis - drug effects Epidermis - enzymology Female Medical sciences Mice Ornithine Decarboxylase - biosynthesis Papilloma - enzymology Phorbols - administration & dosage Terpenes - pharmacology Tetradecanoylphorbol Acetate - administration & dosage Transplantability Tretinoin - pharmacology Tumor cell Tumors
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