Mutagenic potential of nitroguanidine and nitrosoguanidine in the Drosophila melanogaster sex-linked recessive lethal assay
Nitroguanidine (NG) and its degradation product nitrosoguanidine (NSG) were evaluated for their mutagenic potential by using Drosophila melanogaster sex‐linked recessive lethal (SLRL) assay. Following 72 h of feeding exposure, NG and NSG at concentrations of 4–8 μg ml−1 and 15–20 mg ml−1, respective...
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| Veröffentlicht in: | Journal of applied toxicology 1993-07, Vol.13 (4), p.231-234 |
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| creator | Gupta, Raj K. Korte Jr, Don W. Reddy, Gunda |
| description | Nitroguanidine (NG) and its degradation product nitrosoguanidine (NSG) were evaluated for their mutagenic potential by using Drosophila melanogaster sex‐linked recessive lethal (SLRL) assay. Following 72 h of feeding exposure, NG and NSG at concentrations of 4–8 μg ml−1 and 15–20 mg ml−1, respectively, were not mutagenic in the test system. The frequencies of mutations for NG and the negative control were 0.188% and 0.096%, respectively. The frequencies of mutations for NSG and the negative control experiments were 0.049% and 0.05%, respectively. The positive control mutation frequencies were 15% and 17.8% for the two assays. The differences between the mutation frequencies of NG and NSG and their negative controls were not significant. |
| doi_str_mv | 10.1002/jat.2550130404 |
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Following 72 h of feeding exposure, NG and NSG at concentrations of 4–8 μg ml−1 and 15–20 mg ml−1, respectively, were not mutagenic in the test system. The frequencies of mutations for NG and the negative control were 0.188% and 0.096%, respectively. The frequencies of mutations for NSG and the negative control experiments were 0.049% and 0.05%, respectively. The positive control mutation frequencies were 15% and 17.8% for the two assays. The differences between the mutation frequencies of NG and NSG and their negative controls were not significant.</description><identifier>ISSN: 0260-437X</identifier><identifier>EISSN: 1099-1263</identifier><identifier>DOI: 10.1002/jat.2550130404</identifier><identifier>PMID: 8376722</identifier><identifier>CODEN: JJATDK</identifier><language>eng</language><publisher>Chichester: John Wiley & Sons, Ltd</publisher><subject>Animals ; Biological and medical sciences ; Chemical mutagenesis ; Drosophila ; Drosophila melanogaster - drug effects ; Drosophila melanogaster - genetics ; Genetic Linkage ; Guanidines - toxicity ; Medical sciences ; mutagenic potential ; Mutagenicity Tests ; Mutation ; nitroguanidine ; nitrosoguanidine ; Nitrosoguanidines - toxicity ; propellant ; sex-linked recessive lethal assay ; Toxicology ; X Chromosome - drug effects</subject><ispartof>Journal of applied toxicology, 1993-07, Vol.13 (4), p.231-234</ispartof><rights>Copyright © 1993 John Wiley & Sons, Ltd.</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4384-f262eaea9d9dfb58abda83450095282fdb47e4d5c1d424194dfee3ddb0a8a7e93</citedby><cites>FETCH-LOGICAL-c4384-f262eaea9d9dfb58abda83450095282fdb47e4d5c1d424194dfee3ddb0a8a7e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjat.2550130404$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjat.2550130404$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4816863$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8376722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gupta, Raj K.</creatorcontrib><creatorcontrib>Korte Jr, Don W.</creatorcontrib><creatorcontrib>Reddy, Gunda</creatorcontrib><title>Mutagenic potential of nitroguanidine and nitrosoguanidine in the Drosophila melanogaster sex-linked recessive lethal assay</title><title>Journal of applied toxicology</title><addtitle>J. Appl. Toxicol</addtitle><description>Nitroguanidine (NG) and its degradation product nitrosoguanidine (NSG) were evaluated for their mutagenic potential by using Drosophila melanogaster sex‐linked recessive lethal (SLRL) assay. Following 72 h of feeding exposure, NG and NSG at concentrations of 4–8 μg ml−1 and 15–20 mg ml−1, respectively, were not mutagenic in the test system. The frequencies of mutations for NG and the negative control were 0.188% and 0.096%, respectively. The frequencies of mutations for NSG and the negative control experiments were 0.049% and 0.05%, respectively. The positive control mutation frequencies were 15% and 17.8% for the two assays. The differences between the mutation frequencies of NG and NSG and their negative controls were not significant.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemical mutagenesis</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - drug effects</subject><subject>Drosophila melanogaster - genetics</subject><subject>Genetic Linkage</subject><subject>Guanidines - toxicity</subject><subject>Medical sciences</subject><subject>mutagenic potential</subject><subject>Mutagenicity Tests</subject><subject>Mutation</subject><subject>nitroguanidine</subject><subject>nitrosoguanidine</subject><subject>Nitrosoguanidines - toxicity</subject><subject>propellant</subject><subject>sex-linked recessive lethal assay</subject><subject>Toxicology</subject><subject>X Chromosome - drug effects</subject><issn>0260-437X</issn><issn>1099-1263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtvEzEUhS1EVUJhyw7JC8RuUr_mtawCBKoUNkGws-6M7yRuHU8Ye6ARfx5XEwVY1RtL93znPg4hrzibc8bE5S3EuchzxiVTTD0hM87qOuOikE_JjImCZUqW35-R5yHcMpY0UZ2T80qWRSnEjPy-GSNs0NuW7vuIPlpwtO-ot3HoNyN4a6xHCt5MpfBP0Xoat0jfPVT3W-uA7tCB7zcQIg404H3mrL9DQwdsMQT7E6nDuE0TIAQ4vCBnHbiAL4__Bfn64f168TFbfVl-WlytslbJSmWdKAQCQm1q0zV5BY2BSqo8HZOLSnSmUSUqk7fcKKF4rUyHKI1pGFRQYi0vyNup737of4wYot7Z0KJLu2I_Bs2VTE-UCZxPYJtOCgN2ej_YHQwHzZl-SFuntPXftJPh9bHz2OzQnPBjvEl_c9QhtOC6AXxrwwlTFS-qQiasnrBf1uHhkaH6-mr93wrZ5LUp9PuTF4Y7XZSyzPW3z0u9Xl0zJpcLncs_LMerFw</recordid><startdate>199307</startdate><enddate>199307</enddate><creator>Gupta, Raj K.</creator><creator>Korte Jr, Don W.</creator><creator>Reddy, Gunda</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>199307</creationdate><title>Mutagenic potential of nitroguanidine and nitrosoguanidine in the Drosophila melanogaster sex-linked recessive lethal assay</title><author>Gupta, Raj K. ; Korte Jr, Don W. ; Reddy, Gunda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4384-f262eaea9d9dfb58abda83450095282fdb47e4d5c1d424194dfee3ddb0a8a7e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chemical mutagenesis</topic><topic>Drosophila</topic><topic>Drosophila melanogaster - drug effects</topic><topic>Drosophila melanogaster - genetics</topic><topic>Genetic Linkage</topic><topic>Guanidines - toxicity</topic><topic>Medical sciences</topic><topic>mutagenic potential</topic><topic>Mutagenicity Tests</topic><topic>Mutation</topic><topic>nitroguanidine</topic><topic>nitrosoguanidine</topic><topic>Nitrosoguanidines - toxicity</topic><topic>propellant</topic><topic>sex-linked recessive lethal assay</topic><topic>Toxicology</topic><topic>X Chromosome - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gupta, Raj K.</creatorcontrib><creatorcontrib>Korte Jr, Don W.</creatorcontrib><creatorcontrib>Reddy, Gunda</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Journal of applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gupta, Raj K.</au><au>Korte Jr, Don W.</au><au>Reddy, Gunda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mutagenic potential of nitroguanidine and nitrosoguanidine in the Drosophila melanogaster sex-linked recessive lethal assay</atitle><jtitle>Journal of applied toxicology</jtitle><addtitle>J. Appl. Toxicol</addtitle><date>1993-07</date><risdate>1993</risdate><volume>13</volume><issue>4</issue><spage>231</spage><epage>234</epage><pages>231-234</pages><issn>0260-437X</issn><eissn>1099-1263</eissn><coden>JJATDK</coden><abstract>Nitroguanidine (NG) and its degradation product nitrosoguanidine (NSG) were evaluated for their mutagenic potential by using Drosophila melanogaster sex‐linked recessive lethal (SLRL) assay. Following 72 h of feeding exposure, NG and NSG at concentrations of 4–8 μg ml−1 and 15–20 mg ml−1, respectively, were not mutagenic in the test system. The frequencies of mutations for NG and the negative control were 0.188% and 0.096%, respectively. The frequencies of mutations for NSG and the negative control experiments were 0.049% and 0.05%, respectively. The positive control mutation frequencies were 15% and 17.8% for the two assays. The differences between the mutation frequencies of NG and NSG and their negative controls were not significant.</abstract><cop>Chichester</cop><pub>John Wiley & Sons, Ltd</pub><pmid>8376722</pmid><doi>10.1002/jat.2550130404</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0260-437X |
| ispartof | Journal of applied toxicology, 1993-07, Vol.13 (4), p.231-234 |
| issn | 0260-437X 1099-1263 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Biological and medical sciences Chemical mutagenesis Drosophila Drosophila melanogaster - drug effects Drosophila melanogaster - genetics Genetic Linkage Guanidines - toxicity Medical sciences mutagenic potential Mutagenicity Tests Mutation nitroguanidine nitrosoguanidine Nitrosoguanidines - toxicity propellant sex-linked recessive lethal assay Toxicology X Chromosome - drug effects |
| title | Mutagenic potential of nitroguanidine and nitrosoguanidine in the Drosophila melanogaster sex-linked recessive lethal assay |
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